Rett syndrome: a complex disorder with simple roots (Q38366899)

2 September 2017

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title

Rett syndrome: a complex disorder with simple roots (English)

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2 September 2017

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Matthew J Lyst

1

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Adrian Peter Bird

object named as

Adrian Bird

series ordinal

2

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publication date

3 March 2015

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2 September 2017

published in

Nature Reviews Genetics

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2 September 2017

volume

16

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2 September 2017

issue

5

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2 September 2017

page(s)

261-275

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A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases

2 September 2017

cites work

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Rett syndrome: Revised diagnostic criteria and nomenclature

21 January 2018

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Rett syndrome diagnostic criteria: lessons from the Natural History Study

21 January 2018

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MECP2 mutations in sporadic cases of Rett syndrome are almost exclusively of paternal origin

21 January 2018

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MECP2 mutations in males.

21 January 2018

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Rett syndrome in a boy with a 47,XXY karyotype confirmed by a rare mutation in the MECP2 gene.

21 January 2018

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

21 January 2018

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The major form of MeCP2 has a novel N-terminus generated by alternative splicing

21 January 2018

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A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome

21 January 2018

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A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

21 January 2018

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Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

21 January 2018

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

21 January 2018

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Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons

21 January 2018

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Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons

21 January 2018

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Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

21 January 2018

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Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice

21 January 2018

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An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders

21 January 2018

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Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice

21 January 2018

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Expression pattern of the Rett syndrome gene MeCP2 in primate prefrontal cortex

21 January 2018

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Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

21 January 2018

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Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

21 January 2018

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The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells

21 January 2018

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Reversal of neurological defects in a mouse model of Rett syndrome

21 January 2018

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Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows

21 January 2018

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Adult neural function requires MeCP2.

21 January 2018

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MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain

21 January 2018

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A role for glia in the progression of Rett's syndrome

21 January 2018

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Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology

21 January 2018

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Oligodendrocyte lineage cells contribute unique features to Rett syndrome neuropathology

21 January 2018

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Wild-type microglia arrest pathology in a mouse model of Rett syndrome

21 January 2018

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Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice

21 January 2018

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

21 January 2018

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Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus

21 January 2018

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Cell-type-specific repression by methyl-CpG-binding protein 2 is biased toward long genes

21 January 2018

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Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment

21 January 2018

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Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA

21 January 2018

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Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

21 January 2018

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DNA methylation specifies chromosomal localization of MeCP2.

21 January 2018

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Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo

21 January 2018

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A temporal threshold for formaldehyde crosslinking and fixation

21 January 2018

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DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1.

21 January 2018

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Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

21 January 2018

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Global epigenomic reconfiguration during mammalian brain development

21 January 2018

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Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA

21 January 2018

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MeCP2 binding to DNA depends upon hydration at methyl-CpG

21 January 2018

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MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.

21 January 2018

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Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

21 January 2018

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Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain

21 January 2018

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Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

21 January 2018

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Unusual characteristics of the DNA binding domain of epigenetic regulatory protein MeCP2 determine its binding specificity

21 January 2018

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Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

21 January 2018

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The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

21 January 2018

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5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging

21 January 2018

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A matrix/scaffold attachment region binding protein: Identification, purification, and mode of binding

21 January 2018

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Chicken MAR-Binding Protein ARBP Is Homologous to Rat Methyl-CpG-Binding Protein MeCP2

21 January 2018

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Functional consequences of Rett syndrome mutations on human MeCP2.

21 January 2018

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Methylation-dependent and -independent genomic targeting principles of the MBD protein family.

21 January 2018

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DNA recognition by the methyl-CpG binding domain of MeCP2.

21 January 2018

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Heterogeneity in residual function of MeCP2 carrying missense mutations in the methyl CpG binding domain

21 January 2018

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Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation

21 January 2018

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Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2.

21 January 2018

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Unique physical properties and interactions of the domains of methylated DNA binding protein 2.

21 January 2018

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MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

21 January 2018

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Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses

21 January 2018

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DNA methylation patterns and epigenetic memory

21 January 2018

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MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

21 January 2018

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Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

21 January 2018

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Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

21 January 2018

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The Ski protein family is required for MeCP2-mediated transcriptional repression

21 January 2018

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A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos

21 January 2018

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Methyl-CpG-binding protein MeCP2 represses Sp1-activated transcription of the human leukosialin gene when the promoter is methylated

21 January 2018

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L1 retrotransposition in neurons is modulated by MeCP2

21 January 2018

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Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome

21 January 2018

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Rescue of behavioral and EEG deficits in male and female Mecp2-deficient mice by delayed Mecp2 gene reactivation

21 January 2018

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Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain

21 January 2018

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MeCP2, a key contributor to neurological disease, activates and represses transcription

21 January 2018

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Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

21 January 2018

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Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

21 January 2018

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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

21 January 2018

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Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

21 January 2018

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Rett syndrome and MeCP2: linking epigenetics and neuronal function

21 January 2018

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By hook or by crook: multifaceted DNA-binding properties of MeCP2.

21 January 2018

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Methyl CpG-binding proteins induce large-scale chromatin reorganization during terminal differentiation

21 January 2018

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Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome

21 January 2018

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Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

21 January 2018

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MeCP2 binds cooperatively to its substrate and competes with histone H1 for chromatin binding sites

21 January 2018

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Components of the DNA methylation system of chromatin control are RNA-binding proteins

21 January 2018

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Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

21 January 2018

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Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

21 January 2018

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MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex

21 January 2018

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Crh and Oprm1 mediate anxiety-related behavior and social approach in a mouse model of MECP2 duplication syndrome

21 January 2018

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The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression

21 January 2018

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Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice

21 January 2018

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A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

21 January 2018

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Cerebellar gene expression profiles of mouse models for Rett syndrome reveal novel MeCP2 targets

21 January 2018

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RettBASE: The IRSA MECP2 variation database-a new mutation database in evolution

21 January 2018

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Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes

21 January 2018

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Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome

21 January 2018

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Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3

21 January 2018

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Updating the profile of C-terminal MECP2 deletions in Rett syndrome

21 January 2018

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Methyl-CpG-binding protein 2 (MECP2) mutation type is associated with disease severity in Rett syndrome

21 January 2018

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Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome.

21 January 2018

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Long-read sequence analysis of the MECP2 gene in Rett syndrome patients: correlation of disease severity with mutation type and location.

21 January 2018

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Mutation analysis of the methyl-CpG binding protein 2 gene (MECP2) in patients with Rett syndrome

21 January 2018

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Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

21 January 2018

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MeCP2 Rett mutations affect large scale chromatin organization

21 January 2018

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Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome

21 January 2018

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MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number

21 January 2018

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Submicroscopic duplication in Xq28 causes increased expression of the MECP2 gene in a boy with severe mental retardation and features of Rett syndrome

21 January 2018

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Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males

21 January 2018

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Mild overexpression of MeCP2 causes a progressive neurological disorder in mice

21 January 2018

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Defective body-weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice

21 January 2018

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A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

21 January 2018

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Human-specific regulation of MeCP2 levels in fetal brains by microRNA miR-483-5p

21 January 2018

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Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

21 January 2018

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Activity-dependent neuronal signalling and autism spectrum disorder

21 January 2018

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Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2

21 January 2018

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DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation

21 January 2018

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Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation

21 January 2018

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Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

21 January 2018

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Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

21 January 2018

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Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory

21 January 2018

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Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress.

21 January 2018

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Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons

21 January 2018

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Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities

21 January 2018

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Cellular origins of auditory event-related potential deficits in Rett syndrome

21 January 2018

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Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures

21 January 2018

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MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan

21 January 2018

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MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome

21 January 2018

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ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain

21 January 2018

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The BioGRID interaction database: 2013 update

21 January 2018

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MeCP2: a novel Huntingtin interactor

21 January 2018

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Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.

21 January 2018

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A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing

21 January 2018

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Elevated IKKα accelerates the differentiation of human neuronal progenitor cells and induces MeCP2-dependent BDNF expression

21 January 2018

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Direct homo- and hetero-interactions of MeCP2 and MBD2.

21 January 2018

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Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes

21 January 2018

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Identification of TET1 Partners That Control Its DNA-Demethylating Function.

21 January 2018

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The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity

21 January 2018

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Holocarboxylase synthetase synergizes with methyl CpG binding protein 2 and DNA methyltransferase 1 in the transcriptional repression of long-terminal repeats

21 January 2018

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Co-localization of the oncogenic transcription factor MYCN and the DNA methyl binding protein MeCP2 at genomic sites in neuroblastoma.

21 January 2018

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Somatic mosaicism for a MECP2 mutation associated with classic Rett syndrome in a boy

21 January 2018

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Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain

31 March 2020

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Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA

31 March 2020

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MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome

31 March 2020

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Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR.

31 March 2020

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On a unusual brain atrophy syndrome in hyperammonemia in childhood

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25732612

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Selective dendritic alterations in the cortex of Rett syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25732612

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3897

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Dimensions Publication ID

2 September 2017

1039308527

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