Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance (Q38356685)

2 September 2017

Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance (English)

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2 September 2017

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Michel L Ntemgwa

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Mark Wainberg

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7

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Mark A Wainberg

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Bluma G Brenner

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2 September 2017

2

Jorge L Martinez-Cajas

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2 September 2017

4

Dimitrios Coutsinos

1 reference

2 September 2017

Hong-Tao Xu

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2 September 2017

Fernando A Frankel

series ordinal

5

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2 September 2017

11 February 2009

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describes a project that uses

2 September 2017

ImageQuant

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ImageQuant

2 references

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2644664/fullTextXML

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

cites work

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Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir

6 September 2017

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Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

6 September 2017

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Survey of the temporal changes in HIV-1 replicative fitness in the Amsterdam Cohort

6 September 2017

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6 September 2017

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High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens

6 September 2017

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Negative effect of the M184V mutation in HIV-1 reverse transcriptase on initiation of viral DNA synthesis

6 September 2017

1 reference

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6 September 2017

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Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

6 September 2017

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Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity

6 September 2017

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The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis

14 September 2017

1 reference

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Human immunodeficiency virus type-1 reverse transcriptase exists as post-translationally modified forms in virions and cells

14 September 2017

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Diminished efficiency of HIV-1 reverse transcriptase containing the K65R and M184V drug resistance mutations

14 September 2017

1 reference

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The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.

14 September 2017

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Diminished RNA primer usage associated with the L74V and M184V mutations in the reverse transcriptase of human immunodeficiency virus type 1 provides a possible mechanism for diminished viral replication capacity

14 September 2017

1 reference

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The reverse transcriptase 67N 70R 215Y genotype is the predominant TAM pathway associated with virologic failure among HIV type 1C-infected adults treated with ZDV/ddI-containing HAART in southern Africa

14 September 2017

1 reference

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Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1.

27 September 2017

1 reference

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Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity

23 June 2018

1 reference

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The challenge of HIV-1 subtype diversity.

23 June 2018

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The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

31 August 2018

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Resistance mutations in subtype C HIV type 1 isolates from Indian patients of Mumbai receiving NRTIs plus NNRTIs and experiencing a treatment failure: resistance to AR.

31 August 2018

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Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques

31 August 2018

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HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.

31 August 2018

1 reference

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A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2644664

Mechanistic insights into the suppression of drug resistance by human immunodeficiency virus type 1 reverse transcriptase using alpha-boranophosphate nucleoside analogs

31 August 2018

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Patterns of resistance emerging in HIV-1 from antiretroviral-experienced patients undergoing intensification therapy with tenofovir disoproxil fumarate

31 August 2018

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Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial

31 August 2018

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Drug Resistance Profiles of Recombinant Reverse Transcriptases from Human Immunodeficiency Virus Type 1 Subtypes A/E, B, and C

31 August 2018

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In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA.

31 August 2018

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Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase

31 August 2018

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Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.

31 August 2018

1 reference

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Temporal coordination between initiation of HIV (+)-strand DNA synthesis and primer removal

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19210791

12 December 2020

inferred from PubMed ID database lookup

Kinetics of inhibition of HIV type 1 reverse transcriptase-bearing NRTI-associated mutations by apricitabine triphosphate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19210791

12 December 2020

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Update of the drug resistance mutations in HIV-1: Spring 2008

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19210791

12 December 2020

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Identifiers

DOI

10.1186/1742-4690-6-14

1 reference

Dimensions Publication ID

2 September 2017

0 references

1 reference

2 September 2017

PubMed publication ID

19210791

1 reference