Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents (Q38354213)

2 September 2017

title

Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents (English)

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2 September 2017

Guo Q

1

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2 September 2017

Wang LH

series ordinal

2

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2 September 2017

Ruan KH

series ordinal

3

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2 September 2017

Kulmacz RJ

series ordinal

4

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2 September 2017

language of work or name

English

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publication date

1 August 1996

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

271

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2 September 2017

issue

32

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2 September 2017

page(s)

19134-19139

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Prostaglandins and thromboxanes

2 September 2017

cites work

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Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs

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Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin

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Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

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Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms

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The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

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21 January 2018

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21 January 2018

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Human cyclooxygenase-2 cDNA

21 January 2018

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Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons.

21 January 2018

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Comparison of recombinant cyclooxygenase-2 to native isoforms: aspirin labeling of the active site.

21 January 2018

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Comparison of Hydroperoxide Initiator Requirements for the Cyclooxygenase Activities of Prostaglandin H Synthase-1 and −2

21 January 2018

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Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

21 January 2018

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The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofen

21 January 2018

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Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

21 January 2018

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Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

21 January 2018

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Comparison of the construction of a 3-D model for human thromboxane synthase using P450cam and BM-3 as templates: implications for the substrate binding pocket

21 January 2018

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Determination of total protein

21 January 2018

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Purification and characterization of recombinant human cyclooxygenase-2

21 January 2018

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Isolation and covalent structure of the aspirin-modified, active-site region of prostaglandin synthetase

21 January 2018

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NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

21 January 2018

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Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production

21 January 2018

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Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.271.32.19134

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2 September 2017

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