Mapping of the 5'-2-deoxyribose-5-phosphate lyase active site in DNA polymerase beta by mass spectrometry (Q38313808)

2 September 2017

title

Mapping of the 5'-2-deoxyribose-5-phosphate lyase active site in DNA polymerase beta by mass spectrometry (English)

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2 September 2017

Deterding LJ

1

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2 September 2017

Prasad R

2

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2 September 2017

Mullen GP

3

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2 September 2017

Wilson SH

4

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2 September 2017

Tomer KB

5

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2 September 2017

language of work or name

English

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publication date

1 April 2000

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

275

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2 September 2017

issue

14

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2 September 2017

page(s)

10463-10471

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describes a project that uses

2 September 2017

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Progress toward molecular biology of DNA polymerase beta

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

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Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

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Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.

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Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

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Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps

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Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP

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The base excision repair pathway

21 January 2018

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The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA.

21 January 2018

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Three-dimensional solution structure of the N-terminal domain of DNA polymerase beta and mapping of the ssDNA interaction interface

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Crystal Structures of Human DNA Polymerase β Complexed with Gapped and Nicked DNA: Evidence for an Induced Fit Mechanism,

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Evidence for an imino intermediate in the T4 endonuclease V reaction

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Studies on the catalytic mechanism of five DNA glycosylases. Probing for enzyme-DNA imino intermediates

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The catalytic mechanism of Fpg protein. Evidence for a Schiff base intermediate and amino terminus localization of the catalytic site

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Purification and cloning of Micrococcus luteus ultraviolet endonuclease, an N-glycosylase/abasic lyase that proceeds via an imino enzyme-DNA intermediate

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Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities

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Deoxyribose phosphate excision by the N-terminal domain of the polymerase beta: the mechanism revisited

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Coaxial continuous flow fast atom bombardment in conjunction with tandem mass spectrometry for the analysis of biomolecules.

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Raster3D: photorealistic molecular graphics

21 January 2018

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Catalytic Center of DNA Polymerase β for Excision of Deoxyribose Phosphate Groups†

21 January 2018

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Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase

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DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract.

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Two Pathways for Base Excision Repair in Mammalian Cells

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Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells

21 January 2018

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Reconstitution of the DNA base excision-repair pathway

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1 reference

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Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction

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Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism

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Identification and properties of the catalytic domain of mammalian DNA polymerase beta

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Characterization of the tryptophan fluorescence and hydrodynamic properties of rat DNA polymerase beta

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Assignments of 1H, 15N, and 13C resonances for the backbone and side chains of the N-terminal domain of DNA polymerase beta. Determination of the secondary structure and tertiary contacts

21 January 2018

1 reference

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Acetoacetate Decarboxylase. Identification of Lysine at the Active Site*

21 January 2018

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Preliminary comparison of precursor scans and liquid chromatography-tandem mass spectrometry on a hybrid quadrupole time-of-flight mass spectrometer

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.275.14.10463

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2 September 2017

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