Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. (Q38306892)

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1 November 2019

title

Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases (English)

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1 November 2019

author name string

Y Hashimoto

1

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1 November 2019

H Jiang

2

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1 November 2019

T Niikura

3

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1 November 2019

Y Ito

4

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1 November 2019

A Hagiwara

5

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1 November 2019

K Umezawa

6

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1 November 2019

Y Abe

7

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1 November 2019

Y Murayama

8

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1 November 2019

I Nishimoto

9

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1 November 2019

language of work or name

English

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publication date

1 November 2000

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1 November 2019

published in

Journal of Neuroscience

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1 November 2019

volume

20

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1 November 2019

issue

22

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1 November 2019

page(s)

8401-8409

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A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.

1 November 2019

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A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease.

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Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis

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No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.

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12 December 2020

Neurite degeneration elicited by apolipoprotein E peptides

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12 December 2020

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

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Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

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12 December 2020

Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells

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Apolipoprotein E polymorphism in Pick's disease and in Huntington's disease

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Ligation of low-density lipoprotein receptor-related protein with antibodies elevates intracellular calcium and inositol 1,4, 5-trisphosphate in macrophages

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Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts

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Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease

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Alpha-2-macroglobulin intronic polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease

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Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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12 December 2020

Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.

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12 December 2020

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

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12 December 2020

Introduction of DNA into rat liver with a hand-held gene gun: distribution of the expressed enzyme, [32P]DNA, and Ca2+ flux

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12 December 2020

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

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12 December 2020

The low-density lipoprotein receptor-related protein, a multifunctional apolipoprotein E receptor, modulates hippocampal neurite development

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12 December 2020

Activation of G Proteins Bidirectionally Affects Apoptosis of Cultured Cerebellar Granule Neurons

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12 December 2020

Lack of Association of a Polymorphism in the Low-density Lipoprotein Receptor-Related Protein Gene With Alzheimer Disease

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12 December 2020

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

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Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

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12 December 2020

Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis.

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Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

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Alpha2-macroglobulin polymorphism is not associated with AD or AD-type neuropathology in the Japanese.

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12 December 2020

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

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12 December 2020

G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.

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12 December 2020

Regulation of brain G-protein go by Alzheimer's disease gene presenilin-1.

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12 December 2020

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity

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12 December 2020

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

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12 December 2020

Inhibition of the omega-conotoxin-sensitive calcium current by distinct G proteins

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12 December 2020

Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis

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12 December 2020

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and β-Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures

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12 December 2020

Endothelin-induced apoptosis of A375 human melanoma cells

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12 December 2020

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12 December 2020

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12 December 2020

Risky apolipoprotein in brain

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12 December 2020

Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.

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12 December 2020

Association at LRP gene locus with sporadic late-onset Alzheimer's disease.

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12 December 2020

Protease inhibitors generate cytotoxic fragments from Alzheimer amyloid protein precursor in cDNA-transfected glioma cells

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12 December 2020

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain

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12 December 2020

The apolipoprotein E epsilon 4 allele in Parkinson's disease with Alzheimer lesions.

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12 December 2020

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Alpha2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease

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The deletion polymorphism and Val1000Ile in alpha-2-macroglobulin and Alzheimer disease in Caribbean Hispanics

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12 December 2020

Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein

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Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease

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Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated

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Association between an alpha(2) macroglobulin DNA polymorphism and late-onset Alzheimer's disease

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12 December 2020

The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor.

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Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

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12 December 2020

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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12 December 2020

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

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12 December 2020

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), and apolipoprotein E receptor, with late-onset Alzheimer's disease

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12 December 2020

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons.

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Apolipoprotein E genotype in familial Parkinson's disease. The French Parkinson's Disease Genetics Study Group

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12 December 2020

Low density lipoprotein receptor related protein gene exon 3 polymorphism association with Alzheimer's disease in Chinese

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12 December 2020

No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample.

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12 December 2020

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

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12 December 2020

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

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12 December 2020

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E

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12 December 2020

The expression of the LDL receptor-related protein (LRP) correlates with the differentiation of human neuroblastoma cells

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12 December 2020

A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins

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12 December 2020

Rapid elevation of neuronal cytoplasmic calcium by apolipoprotein E peptide

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12 December 2020

Association between coding variability in the LRP gene and the risk of late-onset Alzheimer's disease.

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12 December 2020

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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12 December 2020

10.1523/JNEUROSCI.20-22-08401.2000

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11069947%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

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1 November 2019

PubMed publication ID

11069947

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