Iron and oxygen sensing: a tale of 2 interacting elements? (Q38266801)

1 September 2017

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title

Iron and oxygen sensing: a tale of 2 interacting elements? (English)

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1 September 2017

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Robert J Simpson

1

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1 September 2017

Andrew T McKie

series ordinal

2

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1 September 2017

publication date

1 February 2015

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1 September 2017

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1 September 2017

volume

7

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1 September 2017

issue

2

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1 September 2017

page(s)

223-231

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Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency

1 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Activated macrophages induce hepcidin expression in HuH7 hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Regulation of intestinal iron absorption: the mucosa takes control?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Mammalian iron metabolism and its control by iron regulatory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Direct evidence favouring the notion that erythropoietin alters iron transport across the isolated intestinal tract of the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Suppression of hepcidin during anemia requires erythropoietic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Identification of erythroferrone as an erythroid regulator of iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Effect of iron overload and iron deficiency on liver hemojuvelin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Conditional disruption of mouse HFE2 gene: maintenance of systemic iron homeostasis requires hepatic but not skeletal muscle hemojuvelin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

The serine protease TMPRSS6 is required to sense iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Matriptase-2- and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Iron regulatory proteins control a mucosal block to intestinal iron absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Hypoxia Inducible Factor-2a Is Translationally Repressed in Response to Dietary Iron Deficiency in Sprague-Dawley Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Iron-dependent regulation of the divalent metal ion transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding. Fine-tuning of mRNA regulation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Role of metabolic H2O2 generation: redox signaling and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

An overview of mechanisms of redox signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Signaling functions of reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Hypoxic regulation of NF-kappaB signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

An intact canonical NF-κB pathway is required for inflammatory gene expression in response to hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Role of STAT1, NF-kappaB, and C/EBPbeta in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-gamma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Signaling role of iron in NF-kappa B activation in hepatic macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Pirin is an iron-dependent redox regulator of NF-κB

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

C/EBP alpha: a critical regulator of genes governing integrative metabolic processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

CHOP-mediated hepcidin suppression modulates hepatic iron load.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

ER stress controls iron metabolism through induction of hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Gene expression of the liver in response to chronic hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

The role of hypoxia in 2-butoxyethanol-induced hemangiosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4MT00225C

21 January 2018

Identifiers

DOI

10.1039/C4MT00225C

1 reference

1 September 2017

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