Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway. (Q38228436)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25014534%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

3 references

26 August 2020

23 January 2021

29 April 2021

Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway (English)

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9 March 2020

1 reference

26 August 2020

intracellular signaling peptides and proteins

1 reference

nuclear factor erythroid 2-related factor 2

23 January 2021

1 reference

29 April 2021

Young-Sam Keum

1

1 reference

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9 March 2020

Bu Young Choi

series ordinal

2

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9 March 2020

language of work or name

English

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publication date

10 July 2014

4 references

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9 March 2020

26 August 2020

23 January 2021

29 April 2021

4 references

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9 March 2020

26 August 2020

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19

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9 March 2020

issue

7

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9 March 2020

page(s)

10074-10089

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Creative Commons Attribution

9 March 2020

copyright license

3 references

26 August 2020

23 January 2021

29 April 2021

0 references

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Reactive oxygen species, cellular redox systems, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Stress-activated cap'n'collar transcription factors in aging and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Inflammation: gearing the journey to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Transcriptional responses to oxidative stress: pathological and toxicological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

When NRF2 talks, who's listening?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Regulation of Nrf2-an update

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Back to the future with ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

E3 ubiquitin ligases and mitosis: embracing the complexity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Genetic and expression aberrations of E3 ubiquitin ligases in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Ubiquitin ligases: cell-cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: basis of biosensor construction, live imaging, and image processing

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Monitoring Keap1-Nrf2 interactions in single live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The Keap1-Nrf2 cell defense pathway--a promising therapeutic target?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Blinded by the Light: The Growing Complexity of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Genetic analysis of cytoprotective functions supported by graded expression of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Beneficial role of Nrf2 in regulating NADPH generation and consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Mitochondrial tumour suppressors: a genetic and biochemical update

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Cancer prevention: from 1727 to milestones of the past 100 years

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Trial watch: BTK inhibitor shows positive results in B cell malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Toward clinical application of the Keap1-Nrf2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Molecular epidemiology and retinoid chemoprevention of head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Retinoid pathway and cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190710074

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

21 January 2018

1 reference

12 December 2020

The guardian recruits cops: the p53-p21 axis delegates prosurvival duties to the Keap1-Nrf2 stress pathway

1 reference

12 December 2020

The Keap1–Nrf2 system as an in vivo sensor for electrophiles

1 reference

12 December 2020

Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

1 reference

12 December 2020

Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress

1 reference

12 December 2020

Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis

1 reference

12 December 2020

Antioxidant-induced modification of INrf2 cysteine 151 and PKC-δ-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance.

1 reference

30 December 2023

https://opencitations.net/index/api/v1/citations/10.1242/JCS.074286

Identifiers

DOI

10.3390/MOLECULES190710074

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25014534%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25014534%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

25014534

1 reference