Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity. (Q38223318)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24966052%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity (English)

1 reference

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21 March 2020

0 references

1 reference

1

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21 March 2020

author name string

Nirupa Sachithanandan

series ordinal

2

1 reference

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21 March 2020

Thomas W Kay

series ordinal

3

1 reference

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21 March 2020

Gregory R Steinberg

series ordinal

4

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21 March 2020

language of work or name

English

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publication date

1 July 2014

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21 March 2020

number of pages

12

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based on heuristic

inferred from page(s)

published in

Biochemical Journal

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21 March 2020

volume

461

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21 March 2020

issue

2

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21 March 2020

page(s)

177-188

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General and Abdominal Adiposity and Risk of Death in Europe

21 March 2020

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SOCS: suppressors of cytokine signalling

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Twenty proteins containing a C-terminal SOCS box form five structural classes

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Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

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The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels

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The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin.

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The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.

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Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter

21 January 2018

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IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma

21 January 2018

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Pim serine/threonine kinases regulate the stability of Socs-1 protein

21 January 2018

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Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.

21 January 2018

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Functional cross-modulation between SOCS proteins can stimulate cytokine signaling

21 January 2018

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SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation

21 January 2018

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Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization

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A family of cytokine-inducible inhibitors of signalling

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Gigantism in mice lacking suppressor of cytokine signalling-2

21 January 2018

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Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans

21 January 2018

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Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

21 January 2018

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Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

21 January 2018

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Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase

21 January 2018

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Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling

21 January 2018

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

21 January 2018

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AMP-activated protein kinase is not down-regulated in human skeletal muscle of obese females

21 January 2018

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Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle

21 January 2018

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CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

21 January 2018

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Overfeeding rapidly induces leptin and insulin resistance

21 January 2018

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Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

21 January 2018

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Attenuation of leptin and insulin signaling by SOCS proteins

21 January 2018

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SOCS-3 is an insulin-induced negative regulator of insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Activation of SOCS-3 by resistin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients

21 January 2018

1 reference

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Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins

21 January 2018

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Amyloid-β induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway

21 January 2018

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Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss

21 January 2018

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Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

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Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

21 January 2018

1 reference

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Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes

21 January 2018

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Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice

21 January 2018

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

21 January 2018

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TLR4 links innate immunity and fatty acid-induced insulin resistance

21 January 2018

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

21 January 2018

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Normalization of obesity-associated insulin resistance through immunotherapy

21 January 2018

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21 January 2018

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Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.

21 January 2018

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

21 January 2018

1 reference

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SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Deficiency in Interferon-γ Results in Reduced Body Weight and Better Glucose Tolerance in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Adipose tissue angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Increased Toll-like receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Metabolic endotoxemia initiates obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

An obesity-associated gut microbiome with increased capacity for energy harvest

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT

21 January 2018

1 reference

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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

21 January 2018

1 reference

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Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

21 January 2018

1 reference

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Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.

21 January 2018

1 reference

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Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Muscle as an endocrine organ: focus on muscle-derived interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

SOCS3 deficiency promotes M1 macrophage polarization and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

21 January 2018

1 reference

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Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

21 January 2018

1 reference

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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Irs1 serine 307 promotes insulin sensitivity in mice

21 January 2018

1 reference

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IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance

21 January 2018

1 reference

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Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor

21 January 2018

1 reference

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Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor

21 January 2018

1 reference

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Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Constitutive expression of suppressor of cytokine signalling-3 in skeletal muscle leads to reduced mobility and overweight in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Socs1 deficiency enhances hepatic insulin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

SOCS-1 deficiency does not prevent diet-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Association of single-nucleotide polymorphisms in the suppressor of cytokine signaling 2 (SOCS2) gene with type 2 diabetes in the Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Estrogen up-regulates hepatic expression of suppressors of cytokine signaling-2 and -3 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

The dual function of hepatic SOCS3 in insulin resistance in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Region-specific leptin resistance within the hypothalamus of diet-induced obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKalpha/beta phosphorylation and decreases PI-3 kinase activity in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140143

21 January 2018

Identifiers

DOI

10.1042/BJ20140143

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24966052%20AND%20SRC:MED&resulttype=core&format=json

release_cs573l6jhjebvgudclxtuutq3a

21 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cs573l6jhjebvgudclxtuutq3a

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference