The extrahepatic role of TFR2 in iron homeostasis. (Q38213383)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847265%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

The extrahepatic role of TFR2 in iron homeostasis (English)

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18 March 2020

1

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18 March 2020

Antonella Nai

series ordinal

2

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18 March 2020

author name string

Alessia Pagani

series ordinal

3

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18 March 2020

Clara Camaschella

series ordinal

4

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18 March 2020

publication date

7 May 2014

1 reference

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Frontiers in Pharmacology

18 March 2020

published in

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18 March 2020

volume

5

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18 March 2020

page(s)

93

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In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin receptor 2 (Tfr2) do not interact.

18 March 2020

cites work

1 reference

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Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

6 September 2017

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An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia

6 September 2017

1 reference

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The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits

6 September 2017

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Severe microcytic anemia but increased erythropoiesis in mice lacking Hfe or Tfr2 and Tmprss6

6 September 2017

1 reference

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Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe

6 September 2017

1 reference

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Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

6 September 2017

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Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

6 September 2017

1 reference

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A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

6 September 2017

1 reference

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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Transferrin-directed internalization and cycling of transferrin receptor 2.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

The serine protease TMPRSS6 is required to sense iron deficiency

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Regulation of transferrin receptor 2 protein levels by transferrin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Lipid rafts and signal transduction

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Transferrin receptor is necessary for development of erythrocytes and the nervous system

6 September 2017

1 reference

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The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice.

6 September 2017

1 reference

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Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.

14 September 2017

1 reference

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Regulation of expression of murine transferrin receptor 2.

23 June 2018

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Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis.

23 June 2018

1 reference

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Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

Hepcidin is decreased in TFR2 hemochromatosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019842

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFPHAR.2014.00093

Hepcidin regulation by HFE and TFR2: is it enough to give a hepatocyte a complex?

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24847265

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24847265

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FPHAR.2014.00093

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847265%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847265%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

24847265

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24847265%20AND%20SRC:MED&resulttype=core&format=json