Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities (Q38212433)

24836924

31 August 2017

title

Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities (English)

1 reference

31 August 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

author name string

Slavica Filipic

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

Danica Agbaba

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

Holger Stark

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

publication date

19 May 2014

1 reference

24836924

CNS Neuroscience & Therapeutics

31 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

page(s)

613-623

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

The physiology of brain histamine.

14 May 2020

cites work

1 reference

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

21 January 2018

1 reference

Histamine in the nervous system

21 January 2018

1 reference

Histamine-containing neurons in the rat hypothalamus

21 January 2018

1 reference

The histamine H4 receptor: Targeting inflammatory disorders

21 January 2018

1 reference

Histamine H4 receptor ligands and their potential therapeutic applications: an update

21 January 2018

1 reference

A detailed mapping of the histamine H(3) receptor and its gene transcripts in rat brain

21 January 2018

1 reference

Increase of acetylcholine release from cortex of freely moving rats by administration of histamine into the nucleus basalis magnocellularis

21 January 2018

1 reference

Importance of histamine in modulatory processes, locomotion and memory

21 January 2018

1 reference

Acetylcholine, histamine, and cognition: two sides of the same coin.

21 January 2018

1 reference

Histamine excites noradrenergic neurons in locus coeruleus in rats

21 January 2018

1 reference

Histamine H3-receptor activation inhibits dopamine synthesis in rat striatum

21 January 2018

1 reference

Histamine H3 receptor activation inhibits dopamine D1 receptor-induced cAMP accumulation in rat striatal slices

21 January 2018

1 reference

Histamine H(3) receptor-mediated inhibition of depolarization-induced, dopamine D(1) receptor-dependent release of [(3)H]-gamma-aminobutryic acid from rat striatal slices

21 January 2018

1 reference

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

21 January 2018

1 reference

Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro.

21 January 2018

1 reference

Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats

21 January 2018

1 reference

Veratridine and other depolarizing agents counteract the inhibitory effect of Mg2+ ions on N-methyl-D-aspartate (NMDA)-induced noradrenaline release in vitro

21 January 2018

1 reference

Histamine neurons in the tuberomamillary nucleus: a whole center or distinct subpopulations?

21 January 2018

1 reference

Histamine pharmacology and new CNS drug targets.

21 January 2018

1 reference

Histamine H3 and dopamine D2 receptor-mediated [35S]GTPgamma[S] binding in rat striatum: evidence for additive effects but lack of interactions.

21 January 2018

1 reference

Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus

21 January 2018

1 reference

The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons

21 January 2018

1 reference

Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata

21 January 2018

1 reference

The histamine H3 receptor as a therapeutic drug target for CNS disorders

21 January 2018

1 reference

The histamine H3 receptor: an attractive target for the treatment of cognitive disorders

21 January 2018

1 reference

Histamine H3 receptor antagonists go to clinics

21 January 2018

1 reference

Histamine H3 antagonists as wake-promoting and pro-cognitive agents

21 January 2018

1 reference

Recent medicinal chemistry of the histamine H3 receptor

21 January 2018

1 reference

Keynote review: histamine H3 receptor antagonists reach out for the clinic

21 January 2018

1 reference

Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development

21 January 2018

1 reference

Perspectives on cognitive domains, H3 receptor ligands and neurological disease

21 January 2018

1 reference

The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders

21 January 2018

1 reference

The human brain is intrinsically organized into dynamic, anticorrelated functional networks

21 January 2018

1 reference

The role of histamine and the tuberomamillary nucleus in the nervous system

21 January 2018

1 reference

The histamine H3 receptor: from gene cloning to H3 receptor drugs

21 January 2018

1 reference

Molecular aspects of the histamine H3 receptor

21 January 2018

1 reference

Constitutive activity of the histamine H3 receptor.

21 January 2018

1 reference

Histamine H3 receptor agonists

21 January 2018

1 reference

Medicinal chemical and pharmacological aspects of imidazole-containing histamine H3 receptor antagonists

21 January 2018

1 reference

Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds

21 January 2018

1 reference

Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas

21 January 2018

1 reference

Recent advances in the development of histamine H3 antagonists

21 January 2018

1 reference

Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders

21 January 2018

1 reference

Histamine H3 Receptor as a Drug Discovery Target

21 January 2018

1 reference

Scaffold variations in amine warhead of histamine H₃ receptor antagonists.

21 January 2018

1 reference

The challenge of drug discovery of a GPCR target: analysis of preclinical pharmacology of histamine H3 antagonists/inverse agonists

21 January 2018

1 reference

En route to new blockbuster anti-histamines: surveying the offspring of the expanding histamine receptor family

21 January 2018

1 reference

Several down, a few to go: histamine H3receptor ligands making the final push towards the market?

21 January 2018

1 reference

Highly potent and selective ligands for histamine H3-receptors

21 January 2018

1 reference

Development of FUB 181, a selective histamine H3-receptor antagonist of high oral in vivo potency with 4-(omega-(arylalkyloxy)alkyl)-1H-imidazole structure

21 January 2018

1 reference

Improvement by FUB 181, a novel histamine H3-receptor antagonist, of learning and memory in the elevated plus-maze test in mice

21 January 2018

1 reference

Inverse agonism or neutral antagonism at G-protein coupled receptors: a medicinal chemistry challenge worth pursuing?

21 January 2018

1 reference

Histamine H3 antagonists for treatment of cognitive deficits in CNS diseases

21 January 2018

1 reference

4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration.

21 January 2018

1 reference

CEP-26401 (Irdabisant), a Potent and Selective Histamine H3 Receptor Antagonist/Inverse Agonist with Cognition-Enhancing and Wake-Promoting Activities

21 January 2018

1 reference

In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease

21 January 2018

1 reference

Optimization of 5-pyridazin-3-one phenoxypropylamines as potent, selective histamine H₃ receptor antagonists with potent cognition enhancing activity

21 January 2018

1 reference

Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyc

21 January 2018

1 reference

BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology

21 January 2018

1 reference

New developments around histamine H(3) receptor antagonists/inverse agonists: a patent review (2010 - present).

21 January 2018

1 reference

Efficacy of the histamine 3 receptor (H3R) antagonist pitolisant (formerly known as tiprolisant; BF2.649) in epilepsy: dose-dependent effects in the human photosensitivity model

21 January 2018

1 reference

Histamine H3 receptor antagonists: from target identification to drug leads

21 January 2018

1 reference

Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist

21 January 2018

1 reference

Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

21 January 2018

1 reference

D-amino acid homopiperazine amides: discovery of A-320436, a potent and selective non-imidazole histamine H(3)-receptor antagonist

21 January 2018

1 reference

Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats

21 January 2018

1 reference

GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models

21 January 2018

1 reference

Discovery of Histamine H3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer's Disease

21 January 2018

1 reference

Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.

21 January 2018

1 reference

Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists

21 January 2018

1 reference

Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists

21 January 2018

1 reference

AZD5213: a novel histamine H3 receptor antagonist permitting high daytime and low nocturnal H3 receptor occupancy, a PET study in human subjects

21 January 2018

1 reference

SAR110894, a potent histamine H₃-receptor antagonist, displays procognitive effects in rodents

21 January 2018

1 reference

Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist

21 January 2018

1 reference

A randomized trial of the efficacy and safety of the H3 antagonist ABT-288 in cognitive impairment associated with schizophrenia.

21 January 2018

1 reference

Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists

21 January 2018

1 reference

The safety, tolerability, pharmacokinetics and cognitive effects of GSK239512, a selective histamine H₃ receptor antagonist in patients with mild to moderate Alzheimer's disease: a preliminary investigation

21 January 2018

1 reference

Randomized controlled study of the histamine H3 inverse agonist MK-0249 in adult attention-deficit/hyperactivity disorder.

21 January 2018

1 reference

Recent advances in the development of hybrid molecules/designed multiple compounds with antiamnesic properties

21 January 2018

1 reference

Multi-Target-Directed Ligands in Alzheimer's Disease Treatment

21 January 2018

1 reference

Multi-target compounds acting in the central nervous system designed from natural products

21 January 2018

1 reference

Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics

21 January 2018

1 reference

Dual-acting drugs: an in vitro study of nonimidazole histamine H3 receptor antagonists combining anticholinesterase activity

21 January 2018

1 reference

Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity

21 January 2018

1 reference

Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities

21 January 2018

1 reference

Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives

21 January 2018

1 reference

Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling

21 January 2018

1 reference

Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity

21 January 2018

1 reference

Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.

21 January 2018

1 reference

Searching for the Multi-Target-Directed Ligands against Alzheimer’s disease: Discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities

21 January 2018

1 reference

Design and QSAR study of analogs of alpha-tocopherol with enhanced antiproliferative activity against human breast adenocarcinoma cells

21 January 2018

1 reference

QSAR study of imidazoline antihypertensive drugs.

21 January 2018

1 reference

QSAR study of selective I1-imidazoline receptor ligands

21 January 2018

1 reference

Design and QSAR study of analogs of gamma-tocotrienol with enhanced antiproliferative activity against human breast cancer cells

21 January 2018

1 reference

Multi-target QSAR and docking study of steroids binding to corticosteroid-binding globulin and sex hormone-binding globulin

21 January 2018

1 reference

Pharmacophore development and SAR studies of imidazoline receptor ligands.

21 January 2018

1 reference

Imidazoline-1 receptor ligands as apoptotic agents: pharmacophore modeling and virtual docking study

21 January 2018

1 reference

Phenylpropiophenone derivatives as potential anticancer agents: synthesis, biological evaluation and quantitative structure-activity relationship study.

21 January 2018

1 reference

Neuropsychology of bipolar disorder: a review

21 January 2018

1 reference

Residual symptoms in depression: an emerging therapeutic target

21 January 2018

1 reference

Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

21 January 2018

1 reference

Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor

21 January 2018

1 reference

Generation of a homology model of the human histamine H3 receptor for ligand docking and pharmacophore-based screening

21 January 2018

1 reference

Residual symptoms in depressed patients who respond acutely to fluoxetine.

21 January 2018

1 reference

12 December 2020

Modulation of acetylcholine release by histamine in the nucleus accumbens

1 reference

12 December 2020

S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist

1 reference

12 December 2020

Histamine-selective H3 receptor ligands and cognitive functions: an overview.

1 reference

12 December 2020

Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives.

1 reference

12 December 2020

Multiple enzyme inhibitions by histamine H3 receptor antagonists as potential procognitive agents.

1 reference

12 December 2020

Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore

1 reference

12 December 2020

Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors

1 reference

12 December 2020

Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors

1 reference

12 December 2020

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors

1 reference

12 December 2020

Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity

1 reference

12 December 2020

Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors

1 reference

12 December 2020

The Akt/GSK-3beta axis as a new signaling pathway of the histamine H(3) receptor.

1 reference

12 December 2020

Histaminergic transmission in the mammalian brain

1 reference

12 December 2020

Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs

1 reference

12 December 2020

Histamine receptor subtypes: a century of rational drug design

1 reference

12 December 2020

Computational analysis of novel drugs designed for use as acetylcholinesterase inhibitors and histamine H3 receptor antagonists for Alzheimer's disease by docking, scoring and de novo evolution

1 reference

12 December 2020

Partial least square and hierarchical clustering in ADMET modeling: prediction of blood-brain barrier permeation of α-adrenergic and imidazoline receptor ligands

1 reference

12 December 2020

Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors

1 reference

12 December 2020

Distribution of the histaminergic neuron system in the central nervous system of rats; a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker

1 reference

12 December 2020

Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors

1 reference

12 December 2020

Drug-protein interactions: two-site binding of heterocyclic ligands to a monomeric hemoglobin

1 reference

12 December 2020

Thioperamide, a histamine H3 receptor antagonist, increases GABA release from the rat hypothalamus

1 reference

12 December 2020

Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist

1 reference

12 December 2020

Identifiers

DOI

10.1111/CNS.12279

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json

14 May 2020

24836924

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493064&resulttype=core&format=json