The network of P-glycoprotein and microRNAs interactions (Q38152293)

29 August 2017

title

The network of P-glycoprotein and microRNAs interactions (English)

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29 August 2017

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5

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1 June 2020

Hugo Seca

2

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M. Helena Vasconcelos

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4

Emília Sousa

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1 June 2020

Vanessa Lopes-Rodrigues

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object named as

Vanessa Lopes-Rodrigues

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author name string

Diana Sousa

3

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language of work or name

English

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publication date

17 October 2013

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International Journal of Cancer

29 August 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24122334%20AND%20SRC:MED&resulttype=core&format=json

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volume

135

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issue

2

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page(s)

253-263

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24122334%20AND%20SRC:MED&resulttype=core&format=json

ABC multidrug transporters: structure, function and role in chemoresistance.

1 June 2020

cites work

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ABC efflux pump-based resistance to chemotherapy drugs.

21 January 2018

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High risk of early resistant relapse for leukaemic patients with presence of multidrug resistance associated P-glycoprotein positive cells in complete remission.

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MDR1 gene expression and treatment outcome in acute myeloid leukemia.

21 January 2018

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Initial P-glycoprotein expression in childhood acute lymphoblastic leukemia: no evidence of prognostic impact in follow-up.

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The prognostic significance of P-glycoprotein, multidrug resistance-related protein 1 and lung resistance protein in pediatric acute lymphoblastic leukemia: a retrospective study of 295 newly diagnosed patients by the Children's Oncology Group

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High Functional P-glycoprotein Activity is More Often Present in T-cell Acute Lymphoblastic Leukaemic Cells in Adults than in Children

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Drug resistance: still a daunting challenge to the successful treatment of AML.

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Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

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The direct activation of human multidrug resistance gene (MDR1) by anticancer agents

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Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients. The percentage of lymphocytes expressing glycoprotein 170 is increased in patients treated with prednisolone

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Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?

21 January 2018

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COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer

21 January 2018

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Regulation of the Mdr1 isoforms in a p53-deficient mouse model

21 January 2018

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Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

21 January 2018

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Drug resistance reversal--are we getting closer?

21 January 2018

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Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen

21 January 2018

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Multidrug resistance phenotype and paclitaxel (Taxol) sensitivity in human renal carcinoma cell lines of different histologic types.

21 January 2018

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MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants

21 January 2018

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Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

21 January 2018

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The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

21 January 2018

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P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation.

21 January 2018

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Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling

21 January 2018

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Multiple physiological functions for multidrug transporter P-glycoprotein?

21 January 2018

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Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib.

21 January 2018

1 reference

Stable reversal of multidrug resistance in colon cancer cells by RNA interference targeting the MDR1 gene

21 January 2018

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Short hairpin RNA-mediated MDR1 gene silencing increases apoptosis of human ovarian cancer cell line A2780/Taxol

21 January 2018

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The P-glycoprotein multidrug transporter.

21 January 2018

1 reference

Three decades of P-gp inhibitors: skimming through several generations and scaffolds.

21 January 2018

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Dual inhibitors of P-glycoprotein and tumor cell growth: (re)discovering thioxanthones.

21 January 2018

1 reference

Structure and ligand-based design of P-glycoprotein inhibitors: a historical perspective

21 January 2018

1 reference

P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs

21 January 2018

1 reference

Biochemistry of multidrug resistance mediated by the multidrug transporter

21 January 2018

1 reference

Targeting multidrug resistance in cancer

21 January 2018

1 reference

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

21 January 2018

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

21 January 2018

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Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

21 January 2018

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Interaction of transported drugs with the lipid bilayer and P-glycoprotein through a solvation exchange mechanism

21 January 2018

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Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

21 January 2018

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Intracellular trafficking of P-glycoprotein

21 January 2018

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Detection of P-glycoprotein in the nuclear envelope of multidrug resistant cells.

21 January 2018

1 reference

Subcellular detection and localization of the drug transporter P-glycoprotein in cultured tumor cells

21 January 2018

1 reference

Dynamic and intracellular trafficking of P-glycoprotein-EGFP fusion protein: Implications in multidrug resistance in cancer

21 January 2018

1 reference

Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells.

21 January 2018

1 reference

P-glycoprotein expression in the Golgi apparatus of multidrug-resistant cells.

21 January 2018

1 reference

Actin disruption inhibits endosomal traffic of P-glycoprotein-EGFP and resistance to daunorubicin accumulation

21 January 2018

1 reference

Subcellular localization and activity of multidrug resistance proteins

21 January 2018

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P-gp localization in mitochondria and its functional characterization in multiple drug-resistant cell lines

21 January 2018

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Mitochondrial localization and activity of P-glycoprotein in doxorubicin-resistant K562 cells.

21 January 2018

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P-Glycoprotein is not present in mitochondrial membranes

21 January 2018

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Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia

21 January 2018

1 reference

Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line

21 January 2018

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Redundancy of biological regulation as the basis of emergence of multidrug resistance.

21 January 2018

1 reference

Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells

21 January 2018

1 reference

Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia.

21 January 2018

1 reference

Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma

21 January 2018

1 reference

p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents

21 January 2018

1 reference

Transcriptional activation of the MDR1 gene by UV irradiation. Role of NF-Y and Sp1.

21 January 2018

1 reference

Reactive oxygen species participate in mdr1b mRNA and P-glycoprotein overexpression in primary rat hepatocyte cultures.

21 January 2018

1 reference

Hyperglycemia induced down-regulation of renal P-glycoprotein expression.

21 January 2018

1 reference

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

21 January 2018

1 reference

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

21 January 2018

1 reference

Post-transcriptional regulation of P-glycoprotein expression in cancer cell lines.

21 January 2018

1 reference

Transcriptional regulation of MDR genes

21 January 2018

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Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.

21 January 2018

1 reference

P-glycoprotein (MDR1) expression in leukemic cells is regulated at two distinct steps, mRNA stabilization and translational initiation

21 January 2018

1 reference

MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

21 January 2018

1 reference

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

21 January 2018

1 reference

Control of translation and mRNA degradation by miRNAs and siRNAs

21 January 2018

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Control of protein synthesis and mRNA degradation by microRNAs

21 January 2018

1 reference

Revisiting the principles of microRNA target recognition and mode of action

21 January 2018

1 reference

21 January 2018

Human MicroRNA targets

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Evolution of microRNA diversity and regulation in animals

21 January 2018

1 reference

MicroRNAs: small RNAs with a big role in gene regulation

21 January 2018

1 reference

Many roads to maturity: microRNA biogenesis pathways and their regulation

21 January 2018

1 reference

MicroRNA-373 induces expression of genes with complementary promoter sequences

21 January 2018

1 reference

Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells

21 January 2018

1 reference

Switching from repression to activation: microRNAs can up-regulate translation

21 January 2018

1 reference

New tricks for animal microRNAS: targeting of amino acid coding regions at conserved and nonconserved sites

21 January 2018

1 reference

microPIR: an integrated database of microRNA target sites within human promoter sequences

21 January 2018

1 reference

miR-138 might reverse multidrug resistance of leukemia cells

21 January 2018

1 reference

Down-regulation of miR-27a might reverse multidrug resistance of esophageal squamous cell carcinoma

21 January 2018

1 reference

MicroRNA-modulated autophagic signaling networks in cancer

21 January 2018

1 reference

MicroRNA regulation of core apoptosis pathways in cancer.

21 January 2018

1 reference

MicroRNAs and the cell cycle

21 January 2018

1 reference

Control of cell proliferation pathways by microRNAs

21 January 2018

1 reference

microRNAs as novel regulators of stem cell pluripotency and somatic cell reprogramming

21 January 2018

1 reference

Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells

21 January 2018

1 reference

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

21 January 2018

1 reference

MicroRNAs, macrocontrol: regulation of miRNA processing

21 January 2018

1 reference

A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells

21 January 2018

1 reference

Chromatin structure analyses identify miRNA promoters

21 January 2018

1 reference

TransmiR: a transcription factor-microRNA regulation database

21 January 2018

1 reference

miRNA, development and disease

21 January 2018

1 reference

From pluripotency to islets: miRNAs as critical regulators of human cellular differentiation

21 January 2018

1 reference

MicroRNAs and diabetic complications

21 January 2018

1 reference

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles.

21 January 2018

1 reference

MicroRNAs in breast cancer initiation and progression

21 January 2018

1 reference

MicroRNAs in pancreatic cancer metabolism

21 January 2018

1 reference

The role of microRNAs in colorectal cancer

21 January 2018

1 reference

miR signatures and the role of miRs in acute myeloid leukaemia

21 January 2018

1 reference

miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation

21 January 2018

1 reference

Regulation exerted by miRNAs in the promoter and UTR sequences: MDR1/P-gp expression as a particular case

21 January 2018

1 reference

Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.

21 January 2018

1 reference

Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia

21 January 2018

1 reference

Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298.

21 January 2018

1 reference

MicroRNA-145 post-transcriptionally regulates the expression and function of P-glycoprotein in intestinal epithelial cells.

21 January 2018

1 reference

MicroRNA-21: A novel therapeutic target in human cancer

21 January 2018

1 reference

MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4

21 January 2018

1 reference

miR-21-mediated tumor growth

21 January 2018

1 reference

MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior

21 January 2018

1 reference

Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells.

21 January 2018

1 reference

Up-regulation of miR-21 Mediates Resistance to Trastuzumab Therapy for Breast Cancer

21 January 2018

1 reference

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)

21 January 2018

1 reference

MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity

21 January 2018

1 reference

Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemothera

21 January 2018

1 reference

Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1

21 January 2018

1 reference

Down-regulation of miR-27a might inhibit proliferation and drug resistance of gastric cancer cells

21 January 2018

1 reference

Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer

21 January 2018

1 reference

Downregulation of miR-122 in the rodent and human hepatocellular carcinomas

21 January 2018

1 reference

Microparticle conferred microRNA profiles--implications in the transfer and dominance of cancer traits

21 January 2018

1 reference

P-glycoprotein enhances radiation-induced apoptotic cell death through the regulation of miR-16 and Bcl-2 expressions in hepatocellular carcinoma cells.

21 January 2018

1 reference

Microvesicles as mediators of intercellular communication in cancer—the emerging science of cellular ‘debris’

21 January 2018

1 reference

Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells

21 January 2018

1 reference

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy.

21 January 2018

1 reference

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells.

21 January 2018

1 reference

Microparticles and their emerging role in cancer multidrug resistance.

21 January 2018

1 reference

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

21 January 2018

1 reference

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

21 January 2018

1 reference

Leukemia cell to endothelial cell communication via exosomal miRNAs.

21 January 2018

1 reference

Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation

21 January 2018

1 reference

Microparticle-associated nucleic acids mediate trait dominance in cancer.

21 January 2018

1 reference

Different modalities of intercellular membrane exchanges mediate cell-to-cell p-glycoprotein transfers in MCF-7 breast cancer cells.

21 January 2018

1 reference

Breast cancer-derived microparticles display tissue selectivity in the transfer of resistance proteins to cells

21 January 2018

1 reference

Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance

21 January 2018

1 reference

Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells

21 January 2018

1 reference

Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.

21 January 2018

1 reference

The interaction of bortezomib with multidrug transporters: implications for therapeutic applications in advanced multiple myeloma and other neoplasias

21 January 2018

1 reference

Role of active drug transporters in refractory multiple myeloma.

21 January 2018

1 reference

Drug resistance in multiple myeloma: novel therapeutic targets within the malignant clone.

21 January 2018

1 reference

Establishment of a human hepatoma multidrug resistant cell line in vitro

21 January 2018

1 reference

Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer

21 January 2018

1 reference

21 January 2018

Cancer statistics, 2009

1 reference

Phase II study of alternating chemotherapy regimens for advanced non-small cell lung cancer

21 January 2018

1 reference

Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells

21 January 2018

1 reference

Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein

21 January 2018

1 reference

Prognostic significance of several biomarkers in epithelial ovarian cancer: a meta-analysis of published studies

21 January 2018

1 reference

Multidrug resistance in breast cancer: a meta-analysis of MDR1/gp170 expression and its possible functional significance.

21 January 2018

1 reference

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

1 reference

Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.

21 January 2018

1 reference

Drug resistance in glioblastoma: a mini review

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/IJC.28500

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24122334%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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