Thymus involution and regeneration: two sides of the same coin? (Q38139859)

29 August 2017

title

Thymus involution and regeneration: two sides of the same coin? (English)

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29 August 2017

Thomas Boehm

1

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29 August 2017

Jeremy B Swann

series ordinal

2

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29 August 2017

language of work or name

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20 September 2013

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Nature Reviews Immunology

29 August 2017

published in

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29 August 2017

volume

13

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29 August 2017

issue

11

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29 August 2017

page(s)

831-838

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Functional evidence for a single endodermal origin for the thymic epithelium.

29 August 2017

cites work

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Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch

31 March 2020

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New member of the winged-helix protein family disrupted in mouse and rat nude mutations

31 March 2020

1 reference

Formation of a functional thymus initiated by a postnatal epithelial progenitor cell

31 March 2020

1 reference

Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium

31 March 2020

1 reference

Whn and mHa3 are components of the genetic hierarchy controlling hair follicle differentiation.

31 March 2020

1 reference

The Wnt signaling antagonist Kremen1 is required for development of thymic architecture

31 March 2020

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31 March 2020

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Transcriptional regulation of thymus organogenesis and thymic epithelial cell differentiation

31 March 2020

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Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations.

31 March 2020

1 reference

HoxGroup 3 Paralogs Regulate the Development and Migration of the Thymus, Thyroid, and Parathyroid Glands

31 March 2020

1 reference

Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos

31 March 2020

1 reference

Thymopoiesis requires Pax9 function in thymic epithelial cells

31 March 2020

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Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

31 March 2020

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Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb

31 March 2020

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Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors.

31 March 2020

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PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches

31 March 2020

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Regulation of thymic epithelium by keratinocyte growth factor

31 March 2020

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BMP signaling is required for normal thymus development

31 March 2020

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Bmp4 and Noggin expression during early thymus and parathyroid organogenesis

31 March 2020

1 reference

Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis

31 March 2020

1 reference

On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network

31 March 2020

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Cell-autonomous role of EphB2 and EphB3 receptors in the thymic epithelial cell organization.

31 March 2020

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Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.

31 March 2020

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Thymic epithelial cells provide WNT signals to developing thymocytes.

31 March 2020

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Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function

31 March 2020

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DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration

31 March 2020

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Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence

31 March 2020

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Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors

31 March 2020

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Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence

31 March 2020

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Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy

31 March 2020

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Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage

31 March 2020

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Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner

31 March 2020

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Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium

31 March 2020

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Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging

31 March 2020

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Thymic cysts originate from Foxn1 positive thymic medullary epithelium

31 March 2020

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Nude thymic rudiment lacking functional foxn1 resembles respiratory epithelium.

31 March 2020

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Two genetically separable steps in the differentiation of thymic epithelium.

31 March 2020

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The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.

31 March 2020

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Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

31 March 2020

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Redefining epithelial progenitor potential in the developing thymus

31 March 2020

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Thymus medulla consisting of epithelial islets each derived from a single progenitor

31 March 2020

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Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors

31 March 2020

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Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells

31 March 2020

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The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance

31 March 2020

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The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

31 March 2020

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Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

31 March 2020

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Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells

31 March 2020

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Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium

31 March 2020

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Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

31 March 2020

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Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin.

31 March 2020

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Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

31 March 2020

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Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus

31 March 2020

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Maintenance of thymic epithelial phenotype requires extrinsic signals in mouse and zebrafish

31 March 2020

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Differential lineage specification of thymic epithelial cells from bipotent precursors revealed by TSCOT promoter activities

31 March 2020

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31 March 2020

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Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?

31 March 2020

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Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults

31 March 2020

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The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life

31 March 2020

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Differentiation of induced pluripotent stem cells to thymic epithelial cells by phenotype

31 March 2020

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Differentiation of pharyngeal endoderm from mouse embryonic stem cell

31 March 2020

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Mouse embryonic stem cell-derived thymic epithelial cell progenitors enhance T-cell reconstitution after allogeneic bone marrow transplantation

31 March 2020

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Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells.

31 March 2020

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Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture

31 March 2020

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Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.

31 March 2020

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Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells

31 March 2020

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Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development

31 March 2020

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Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo

31 March 2020

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An organotypic coculture model supporting proliferation and differentiation of medullary thymic epithelial cells and promiscuous gene expression

31 March 2020

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Positive selection of T cells, an in vitro view.

31 March 2020

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A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells.

31 March 2020

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Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironments

31 March 2020

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Delta-like 4 is indispensable in thymic environment specific for T cell development

31 March 2020

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Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

31 March 2020

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The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma

31 March 2020

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Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction

31 March 2020

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Journey through the thymus: stromal guides for T-cell development and selection

31 March 2020

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Zoned out: functional mapping of stromal signaling microenvironments in the thymus

31 March 2020

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Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development.

31 March 2020

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Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adult

31 March 2020

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Extra-thymic immature T cells: development in polyoma virus-induced murine salivary gland tumors

31 March 2020

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Erythropoiesis in an avian thymus

31 March 2020

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Design principles of adaptive immune systems

31 March 2020

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A thymus candidate in lampreys.

31 March 2020

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Evolution of lymphoid tissues

31 March 2020

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VLR-based adaptive immunity

31 March 2020

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Evolution of the immune system in the lower vertebrates

31 March 2020

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Intravital imaging of thymopoiesis reveals dynamic lympho-epithelial interactions

31 March 2020

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Early human T cell development: analysis of the human thymus at the time of initial entry of hematopoietic stem cells into the fetal thymic microenvironment

31 March 2020

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Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

31 March 2020

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Studies on the NZB mouse thymus. I. Thymus weight relationships to age and body weight from birth to old age

31 March 2020

1 reference

Sex Steroid Ablation Enhances Hematopoietic Recovery following Cytotoxic Antineoplastic Therapy in Aged Mice

31 March 2020

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Persistent degenerative changes in thymic organ function revealed by an inducible model of organ regrowth.

31 March 2020

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Thymic involution and immune reconstitution.

31 March 2020

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Nonrandom attrition of the naive CD8+ T-cell pool with aging governed by T-cell receptor:pMHC interactions

31 March 2020

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Thymus-autonomous T cell development in the absence of progenitor import

31 March 2020

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Self-renewal of thymocytes in the absence of competitive precursor replenishment

31 March 2020

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Reassessing the role of growth hormone and sex steroids in thymic involution

31 March 2020

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Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy

31 March 2020

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Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus

31 March 2020

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Thymic recovery after allogeneic hematopoietic cell transplantation with non-myeloablative conditioning is limited to patients younger than 60 years of age

31 March 2020

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Thymus and immune reconstitution after allogeneic hematopoietic stem cell transplantation in humans: never say never again.

31 March 2020

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Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

31 March 2020

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Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

31 March 2020

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FGFR2IIIb signaling regulates thymic epithelial differentiation

31 March 2020

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Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques

31 March 2020

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Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion

31 March 2020

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Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence.

31 March 2020

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TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.

31 March 2020

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Tolerance has its limits: how the thymus copes with infection

31 March 2020

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The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor

31 March 2020

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The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence

31 March 2020

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Interleukin-22 drives endogenous thymic regeneration in mice

31 March 2020

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An epithelial progenitor pool regulates thymus growth

31 March 2020

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Regenerative capacity of adult cortical thymic epithelial cells

31 March 2020

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A single progenitor population switches behavior to maintain and repair esophageal epithelium

31 March 2020

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Distinct contribution of stem and progenitor cells to epidermal maintenance

31 March 2020

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Thymus transplantation in complete DiGeorge anomaly

31 March 2020

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The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly

31 March 2020

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Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation

31 March 2020

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Generation of thymic epithelial cell progenitors by mouse embryonic stem cells

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24052146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24052146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3534

1 reference

29 August 2017

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