Head and neck cancer: from anatomy to biology (Q38082457)

28 August 2017

title

Head and neck cancer: from anatomy to biology (English)

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28 August 2017

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head and neck carcinoma

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Pinaki Bose

1

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28 August 2017

Nigel T Brockton

series ordinal

2

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28 August 2017

Joseph C Dort

series ordinal

3

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28 August 2017

language of work or name

English

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publication date

29 March 2013

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International Journal of Cancer

28 August 2017

published in

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28 August 2017

volume

133

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28 August 2017

issue

9

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28 August 2017

page(s)

2013-2023

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Global cancer statistics, 2002

28 August 2017

cites work

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Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers

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Common markers of proliferation.

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Dysregulated molecular networks in head and neck carcinogenesis

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

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11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours

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p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status

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Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming

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Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis

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The molecular biology of head and neck cancer

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The molecular pathogenesis of head and neck squamous cell carcinoma

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The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms

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TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

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The epigenetics of oral cancer

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Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma

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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

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The mutational landscape of head and neck squamous cell carcinoma

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Differential roles of p16INK4A and p14ARF genes in prognosis of oral carcinoma.

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Radioimmunotherapy of experimental head and neck squamous cell carcinoma (HNSCC) with E6-specific antibody using a novel HPV-16 positive HNSCC cell line

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Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia

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Nuclear localization of EGF receptor and its potential new role as a transcription factor

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Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

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Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma.

21 January 2018

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Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma

21 January 2018

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Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas

21 January 2018

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Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study

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Potential molecular prognostic markers in head and neck squamous cell carcinomas

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Epidermal growth factor receptor directed therapy in head and neck cancer

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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Untangling the ErbB signalling network

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Molecular therapy in head and neck oncology

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ERBB receptors and cancer: the complexity of targeted inhibitors

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Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

21 January 2018

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Platinum-based chemotherapy plus cetuximab in head and neck cancer

21 January 2018

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Understanding resistance to EGFR inhibitors-impact on future treatment strategies

21 January 2018

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Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting

21 January 2018

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Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck

21 January 2018

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Expression of Amphiregulin and EGFRvIII Affect Outcome of Patients with Squamous Cell Carcinoma of the Head and Neck Receiving Cetuximab–Docetaxel Treatment

21 January 2018

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A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors

21 January 2018

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Identification and characterization of Ch806 mimotopes

21 January 2018

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Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

21 January 2018

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Specific and Sensitive Hydrolysis Probe-Based Real-Time PCR Detection of Epidermal Growth Factor Receptor Variant III in Oral Squamous Cell Carcinoma

21 January 2018

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Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features.

21 January 2018

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Evidence for mesenchymal-like sub-populations within squamous cell carcinomas possessing chemoresistance and phenotypic plasticity

21 January 2018

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Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members

21 January 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

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Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

21 January 2018

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PIK3CA mutations in head and neck squamous cell carcinoma

21 January 2018

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PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors

21 January 2018

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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

21 January 2018

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A phase I study of temsirolimus plus carboplatin plus paclitaxel for patients with recurrent or metastatic (R/M) head and neck squamous cell cancer (HNSCC)

21 January 2018

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Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer

21 January 2018

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mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas

21 January 2018

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Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

21 January 2018

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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

21 January 2018

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Abl oncogene bypasses normal regulation of Jak/STAT activation

21 January 2018

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Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro

21 January 2018

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Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

21 January 2018

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Receptor-mediated tobacco toxicity: cooperation of the Ras/Raf-1/MEK1/ERK and JAK-2/STAT-3 pathways downstream of alpha7 nicotinic receptor in oral keratinocytes

21 January 2018

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Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting

21 January 2018

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Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemia

21 January 2018

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JAK inhibitors for myeloproliferative neoplasms: clarifying facts from myths

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Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches

21 January 2018

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First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy.

21 January 2018

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Targeting Stat3 abrogates EGFR inhibitor resistance in cancer.

21 January 2018

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Synergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy

21 January 2018

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Hypoxia in head and neck cancer

21 January 2018

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Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis

21 January 2018

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Hypoxia in head and neck cancer: how much, how important?

21 January 2018

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Interdependence of hypoxic and innate immune responses

21 January 2018

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Hypoxia-driven selection of the metastatic phenotype

21 January 2018

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Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

21 January 2018

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Hypoxia-inducible factors in OSCC.

21 January 2018

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Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

21 January 2018

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A microenvironmental model of carcinogenesis.

21 January 2018

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Carbonic anhydrase IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with β-catenin

21 January 2018

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Influence of oxygen concentration and pH on expression of hypoxia induced genes.

21 January 2018

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Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion

21 January 2018

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Microenvironmental and cellular consequences of altered blood flow in tumours

21 January 2018

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High Stromal Carbonic Anhydrase IX Expression Is Associated With Decreased Survival in p16-Negative Head-and-Neck Tumors

21 January 2018

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High stromal carbonic anhydrase IX expression is associated with nodal metastasis and decreased survival in patients with surgically-treated oral cavity squamous cell carcinoma

21 January 2018

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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

21 January 2018

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Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck – A systematic review and meta-analysis

21 January 2018

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ARCON: a novel biology-based approach in radiotherapy

21 January 2018

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HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer

21 January 2018

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Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial

21 January 2018

1 reference

Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives

21 January 2018

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A phase I trial of PR-104, a nitrogen mustard prodrug activated by both hypoxia and aldo-keto reductase 1C3, in patients with solid tumors.

21 January 2018

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Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

21 January 2018

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Recent developments in targeting carbonic anhydrase IX for cancer therapeutics

21 January 2018

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Targeting microRNAs in cancer: rationale, strategies and challenges

21 January 2018

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A microRNA expression signature of human solid tumors defines cancer gene targets

21 January 2018

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Causes and consequences of microRNA dysregulation in cancer

21 January 2018

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MicroRNA alterations in head and neck squamous cell carcinoma.

21 January 2018

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miRNA expression profiles in head and neck squamous cell carcinoma and adjacent normal tissue

21 January 2018

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Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas

21 January 2018

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Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection

21 January 2018

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MicroRNA expression profiles in head and neck cancer cell lines

21 January 2018

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Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma

21 January 2018

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Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy

21 January 2018

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Down-regulation of the microRNA-99 family members in head and neck squamous cell carcinoma

21 January 2018

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RAS is regulated by the let-7 microRNA family

21 January 2018

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Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b

21 January 2018

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The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2

21 January 2018

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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

21 January 2018

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Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling

21 January 2018

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MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression

21 January 2018

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Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma

21 January 2018

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MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer

21 January 2018

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MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma

21 January 2018

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Detection of metastatic head and neck squamous cell carcinoma using the relative expression of tissue-specific mir-205

21 January 2018

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Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

21 January 2018

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Association of p16INK4a overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue

21 January 2018

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Identifiers

DOI

10.1002/IJC.28112

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28 August 2017

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