Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response (Q38027076)

27 August 2017

title

Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response (English)

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27 August 2017

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2

Rolf Hilgenfeld

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27 August 2017

Guido Hansen

1

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27 August 2017

publication date

18 July 2012

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Cellular and Molecular Life Sciences

27 August 2017

published in

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27 August 2017

volume

70

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27 August 2017

issue

5

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27 August 2017

page(s)

761-775

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Evolution of peptidase diversity

27 August 2017

cites work

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HTRA proteases: regulated proteolysis in protein quality control

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Overproduction or absence of the periplasmic protease DegP severely compromises bacterial growth in the absence of the dithiol: disulfide oxidoreductase DsbA

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The Legionella HtrA homologue DegQ is a self-compartmentizing protease that forms large 12-meric assemblies

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Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins

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Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure

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Molecular Adaptation of the DegQ Protease to Exert Protein Quality Control in the Bacterial Cell Envelope

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Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

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Structural basis for the regulated protease and chaperone function of DegP

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Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins.

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Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

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Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control

21 January 2018

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Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

21 January 2018

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Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis

21 January 2018

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DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response

21 January 2018

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Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease

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A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

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Listeria monocytogenes 10403S HtrA is necessary for resistance to cellular stress and virulence

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Role for HtrA in stress induction and virulence potential in Listeria monocytogenes.

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Effect of inactivation of degS on Salmonella enterica serovar typhimurium in vitro and in vivo

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Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo

21 January 2018

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Effect of inactivation of the HtrA-like serine protease DegQ on the virulence of Salmonella enterica serovar Typhimurium in mice

21 January 2018

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HtrA is a major virulence determinant of Bacillus anthracis

21 January 2018

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Envelope stress responses and Gram-negative bacterial pathogenesis.

21 January 2018

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OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain

21 January 2018

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Conversion of a regulatory into a degradative protease

21 January 2018

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Allosteric activation of DegS, a stress sensor PDZ protease

21 January 2018

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Signal integration by DegS and RseB governs the σ E-mediated envelope stress response in Escherichia coli

21 January 2018

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Structural analysis of DegS, a stress sensor of the bacterial periplasm

21 January 2018

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Allostery Is an Intrinsic Property of the Protease Domain of DegS: IMPLICATIONS FOR ENZYME FUNCTION AND EVOLUTION

21 January 2018

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OMP Peptides Activate the DegS Stress-Sensor Protease by a Relief of Inhibition Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mechanism of heat-inducible transcription

21 January 2018

1 reference

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Molecular transformers in the cell: lessons learned from the DegP protease-chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Cage assembly of DegP protease is not required for substrate-dependent regulation of proteolytic activity or high-temperature cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

The inner cavity of Escherichia coli DegP protein is not essential for molecular chaperone and proteolytic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation

21 January 2018

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Structure and function of HtrA family proteins, the key players in protein quality control

21 January 2018

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Crystal structure of the protease domain of a heat-shock protein HtrA from Thermotoga maritima

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

The mechanism of temperature-induced bacterial HtrA activation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Is Mycobacterium tuberculosis a closer relative to Gram-positive or Gram-negative bacterial pathogens?

21 January 2018

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Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

21 January 2018

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Substrate-induced remodeling of the active site regulates human HTRA1 activity

21 January 2018

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D1-protein dynamics in photosystem II: the lingering enigma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Expression and characterization of a serine protease that preferentially cleaves insulin-like growth factor binding protein-5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Implications of the serine protease HtrA1 in amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

The role of human HtrA1 in arthritic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

HtrA serine proteases as potential therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Emerging roles of serine proteinases in tissue turnover in arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

The mitochondrial serine protease HtrA2/Omi: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Selection of neural differentiation-specific genes by comparing profiles of random differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

The structural basis of mode of activation and functional diversity: A case study with HtrA family of serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

SMART 7: recent updates to the protein domain annotation resource

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

A specificity map for the PDZ domain family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

PDZ domains and their binding partners: structure, specificity, and modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Extensions of PDZ domains as important structural and functional elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

A Systematic Family-wide Investigation Reveals that ∼30% of Mammalian PDZ Domains Engage in PDZ-PDZ Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Domain Swapping within PDZ2 Is Responsible for Dimerization of ZO Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Crystal structure of GRIP1 PDZ6-peptide complex reveals the structural basis for class II PDZ target recognition and PDZ domain-mediated multimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Role of HtrA in surface protein expression and biofilm formation by Streptococcus mutans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Role of DegP for two-partner secretion in Bordetella

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1076-4

Age-related macular degeneration

21 January 2018

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12 December 2020

MEROPS: the peptidase database

1 reference

12 December 2020

Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis

1 reference

12 December 2020

Selective degradation of unfolded proteins by the self-compartmentalizing HtrA protease, a periplasmic heat shock protein in Escherichia coli

1 reference

12 December 2020

PDZ domains - common players in the cell signaling

1 reference

12 December 2020

The Escherichia coli heat shock protease HtrA participates in defense against oxidative stress

1 reference

12 December 2020

10.1007/S00018-012-1076-4

Identifiers

DOI

1 reference

27 August 2017

1 reference