The diverse and complex roles of NF-κB subunits in cancer (Q37976939)

26 August 2017

title

The diverse and complex roles of NF-κB subunits in cancer (English)

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26 August 2017

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Neil D Perkins

1

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26 August 2017

language of work or name

English

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publication date

19 January 2012

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26 August 2017

published in

Nature Reviews Cancer

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26 August 2017

volume

12

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26 August 2017

issue

2

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26 August 2017

page(s)

121-132

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Inflammation meets cancer, with NF-κB as the matchmaker

26 August 2017

cites work

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Immunity, Inflammation, and Cancer

21 January 2018

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Inhibitors of NF-kappaB signaling: 785 and counting

21 January 2018

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Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

21 January 2018

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The NF-kappaB-independent functions of IKK subunits in immunity and cancer

21 January 2018

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Integrating cell-signalling pathways with NF-kappaB and IKK function

21 January 2018

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The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives

21 January 2018

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Regulation of the RelA (p65) transactivation domain

21 January 2018

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Shared principles in NF-kappaB signaling

21 January 2018

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Ubiquitination and degradation of the inhibitors of NF-kappaB

21 January 2018

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IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response

21 January 2018

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Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

21 January 2018

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IkappaB kinase is an essential component of the Tpl2 signaling pathway

21 January 2018

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Signaling to NF-kappaB: regulation by ubiquitination

21 January 2018

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Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

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NF-kappaB and IKK as therapeutic targets in cancer

21 January 2018

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Nuclear factor-kappaB: its role in health and disease

21 January 2018

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Nuclear factor-kappaB in cancer development and progression

21 January 2018

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An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

21 January 2018

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Regulation of programmed cell death by NF-kappaB and its role in tumorigenesis and therapy

21 January 2018

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Good cop, bad cop: the different faces of NF-kappaB

21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation

21 January 2018

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p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF-κB

21 January 2018

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

21 January 2018

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NF-kappaB as a critical link between inflammation and cancer

21 January 2018

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IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

21 January 2018

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Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer

21 January 2018

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B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

21 January 2018

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Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

21 January 2018

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Deubiquitinases in the regulation of NF-κB signaling

21 January 2018

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Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription

21 January 2018

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Population robustness arising from cellular heterogeneity

21 January 2018

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Mutations in the NF-kappaB signaling pathway: implications for human disease

21 January 2018

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Classical and/or alternative NF-kappaB pathway activation in multiple myeloma

21 January 2018

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Oncogenic activation of NF-kappaB.

21 January 2018

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Inflammation and oncogenesis: a vicious connection

21 January 2018

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

21 January 2018

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Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

21 January 2018

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Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis

21 January 2018

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Genetic analysis of NF- B/Rel transcription factors defines functional specificities

21 January 2018

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Osteopetrosis in mice lacking NF-κB1 and NF-κB2

21 January 2018

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The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

21 January 2018

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Multiple myeloma: lusting for NF-kappaB.

21 January 2018

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Patterns of somatic mutation in human cancer genomes

21 January 2018

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Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

21 January 2018

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Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

21 January 2018

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Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

21 January 2018

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The Biphasic Role of NF-κB in Progression and Chemoresistance of Ovarian Cancer

21 January 2018

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Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.

21 January 2018

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Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

21 January 2018

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Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway

21 January 2018

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Phosphorylation of the p52 NF-κB subunit

21 January 2018

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TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation

21 January 2018

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Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon

21 January 2018

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Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation

21 January 2018

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The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

21 January 2018

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cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.

21 January 2018

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The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis.

21 January 2018

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Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination

21 January 2018

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GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA

21 January 2018

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p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.

21 January 2018

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Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation

21 January 2018

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Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms.

21 January 2018

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Mechanism of hypoxia-induced NF-kappaB.

21 January 2018

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The nuclear factor kappaB subunits RelA/p65 and c-Rel potentiate but are not required for Ras-induced cellular transformation.

21 January 2018

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Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways.

21 January 2018

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p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism

21 January 2018

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CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling

21 January 2018

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Transcriptional cross talk between NF-kappaB and p53.

21 January 2018

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Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB

21 January 2018

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p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy

21 January 2018

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INK4 cell cycle inhibitors direct transcriptional inactivation of NF-kappaB

21 January 2018

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LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB

21 January 2018

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CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB.

21 January 2018

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TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway

21 January 2018

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PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit

21 January 2018

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NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

21 January 2018

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Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.

21 January 2018

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The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation

21 January 2018

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Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B.

21 January 2018

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p53-mediated induction of Noxa and p53AIP1 requires NFkappaB.

21 January 2018

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Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

21 January 2018

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Cross talk between stimulated NF-kappaB and the tumor suppressor p53.

21 January 2018

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High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53-NF-kappaB-complex-dependent gene expression in human heart failure

21 January 2018

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TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer

21 January 2018

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ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

21 January 2018

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SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

21 January 2018

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Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

21 January 2018

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RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair

21 January 2018

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Activation of nuclear factor-kappa B signalling promotes cellular senescence

21 January 2018

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

21 January 2018

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Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

21 January 2018

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Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression

21 January 2018

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A novel nuclear factor-kappaB gene signature is differentially expressed in head and neck squamous cell carcinomas in association with TP53 status

21 January 2018

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IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation

21 January 2018

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Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.

21 January 2018

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

21 January 2018

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SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death

21 January 2018

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

21 January 2018

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Many faces of NF-kappaB signaling induced by genotoxic stress

21 January 2018

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A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation

21 January 2018

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ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

21 January 2018

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IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function

21 January 2018

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Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress

21 January 2018

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NF-κB Potentiates Caspase Independent Hydrogen Peroxide Induced Cell Death

21 January 2018

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Regulation of activity and function of the p52 NF-κB subunit following DNA damage

21 January 2018

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Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin

21 January 2018

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Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response

21 January 2018

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NF-kappa B activation mediates doxorubicin-induced cell death in N-type neuroblastoma cells

21 January 2018

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Differential regulation of NF-kappaB activation and function by topoisomerase II inhibitors

21 January 2018

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Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells

21 January 2018

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Inhibition of RelA phosphorylation sensitizes apoptosis in constitutive NF-kappaB-expressing and chemoresistant cells

21 January 2018

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Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

21 January 2018

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Bortezomib in the treatment of cancer

21 January 2018

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The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

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Inhibition of NF-κB signaling as a strategy in disease therapy

21 January 2018

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Structure-based design and biological profile of (E)-N-(4-Nitrobenzylidene)-2-naphthohydrazide, a novel small molecule inhibitor of IκB kinase-β

21 January 2018

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Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.

21 January 2018

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A novel, highly selective, tight binding IkappaB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models.

21 January 2018

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Nuclear factor-kappa B inhibitors; a patent review (2006-2010).

21 January 2018

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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

21 January 2018

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Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases

21 January 2018

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Inhibition of immune activation by a novel nuclear factor-kappa B inhibitor in HTLV-I–associated neurologic disease

21 January 2018

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Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

21 January 2018

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Structural studies of NF-κB signaling

21 January 2018

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Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis

21 January 2018

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Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis

21 January 2018

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Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity

21 January 2018

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A cell cycle regulatory network controlling NF-kappaB subunit activity and function

21 January 2018

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p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.

21 January 2018

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The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition

21 January 2018

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Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

21 January 2018

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Nutlin-3 inhibits the NFkappaB pathway in a p53-dependent manner: implications in lung cancer therapy.

21 January 2018

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The clinical development of inhibitors of poly(ADP-ribose) polymerase.

21 January 2018

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Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance

21 January 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

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Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers.

21 January 2018

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A feed-forward circuit controlling inducible NF-κB target gene activation by promoter histone demethylation

21 January 2018

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Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

21 January 2018

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WIP1 phosphatase is a negative regulator of NF-kappaB signalling

21 January 2018

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CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

21 January 2018

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Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

21 January 2018

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TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer.

21 January 2018

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Jmjd3 contributes to the control of gene expression in LPS-activated macrophages

21 January 2018

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Identification of a tumor-associated mutant form of the NF-kappaB RelA gene with reduced DNA-binding and transactivating activities

21 January 2018

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Mutation of an IKK phosphorylation site within the transactivation domain of REL in two patients with B-cell lymphoma enhances REL's in vitro transforming activity

21 January 2018

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Variants of the RELA gene are associated with schizophrenia and their startle responses

21 January 2018

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Identification of possible genetic polymorphisms involved in cancer cachexia: a systematic review

21 January 2018

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Association Between NFKB1 -94ins/delATTG Promoter Polymorphism and Cancer Risk: A Meta-Analysis

21 January 2018

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

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p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

21 January 2018

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Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

21 January 2018

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IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

21 January 2018

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Mutations within a conserved protein kinase A recognition sequence confer temperature-sensitive and partially defective activities onto mouse c-Rel

21 January 2018

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Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

31 March 2020

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Combined use of pharmacokinetic modeling and a steady-state delivery approach allows early assessment of IkappaB kinase-2 (IKK-2) target safety and efficacy

31 March 2020

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NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699.

31 March 2020

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12 December 2020

NFκB/p53 crosstalk-a promising new therapeutic target.

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12 December 2020

The Catalogue of Somatic Mutations in Cancer (COSMIC)

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12 December 2020

Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination

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12 December 2020

p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300

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12 December 2020

Identifiers

DOI

10.1038/NRC3204

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26 August 2017

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