Small Molecule Allosteric Modulators of Phosphodiesterase 4 (Q37893064)

24 August 2017

1 reference

title

Small Molecule Allosteric Modulators of Phosphodiesterase 4 (English)

1 reference

https://api.crossref.org/works/10.1007/978-3-642-17969-3_7

5 December 2024

2

Alex B Burgin

1 reference

24 August 2017

3

Olafur T. Magnusson

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21695640

5 December 2024

author name string

Mark E. Gurney

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21695640

5 December 2024

Lance J. Stewart

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21695640

5 December 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21695640

5 December 2024

publication date

1 January 2011

1 reference

24 August 2017

2011

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21695640

full work available at URL

5 December 2024

http://link.springer.com/content/pdf/10.1007/978-3-642-17969-3_7

1 reference

https://api.crossref.org/works/10.1007/978-3-642-17969-3_7

Handbook of experimental pharmacology

5 December 2024

published in

1 reference

24 August 2017

issue

204

1 reference

24 August 2017

page(s)

167-192

1 reference

A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines

24 August 2017

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PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex

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Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons

5 December 2024

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A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

5 December 2024

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The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network

5 December 2024

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5 December 2024

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5 December 2024

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Characterization of a hormone-inducible, high affinity adenosine 3'-5'-cyclic monophosphate phosphodiesterase from the rat Sertoli cell

5 December 2024

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Regulation and organization of adenylyl cyclases and cAMP.

5 December 2024

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Cloning and characterization of mammalian homologs of the Drosophila dunce+ gene

5 December 2024

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5 December 2024

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Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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5 December 2024

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Clinical and Biochemical Effects of the Selective Phosphodiesterase Inhibitor Rolipram in Depressed Inpatients Controlled by Determination of Plasma Level

5 December 2024

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Crystal structure of phosphodiesterase 4D and inhibitor complex(1)

5 December 2024

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Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias

5 December 2024

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Antidepressant- and anxiolytic-like effects of the phosphodiesterase-4 inhibitor rolipram on behavior depend on cyclic AMP response element binding protein-mediated neurogenesis in the hippocampus

5 December 2024

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Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease

5 December 2024

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Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors.

5 December 2024

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5 December 2024

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Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

5 December 2024

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RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

5 December 2024

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ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

5 December 2024

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Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition

5 December 2024

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DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

5 December 2024

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Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

5 December 2024

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Discovery of selective PDE4B inhibitors

5 December 2024

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Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

5 December 2024

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Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain

5 December 2024

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Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer

5 December 2024

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Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs).

5 December 2024

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5 December 2024

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PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

5 December 2024

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Assessing the emetic potential of PDE4 inhibitors in rats

5 December 2024

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Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

5 December 2024

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Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

5 December 2024

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5 December 2024

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Interaction of metoprolol with lorazepam and bromazepam

5 December 2024

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5 December 2024

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The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3

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Targeting the CREB pathway for memory enhancers

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Suncus murinus: a new experimental model in emesis research

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The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10

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cAMP microdomains and L-type Ca2+ channel regulation in guinea-pig ventricular myocytes

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An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

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Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

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The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform

5 December 2024

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Results of a phase II study of the antidepressant effect of rolipram

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A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases

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Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats

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Identifiers

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24 August 2017

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