Inhibitors of Translation Initiation as Cancer Therapeutics (Q37855822)

24 August 2017

1 reference

title

Inhibitors of translation initiation as cancer therapeutics (English)

1 reference

24 August 2017

Inhibitors of Translation Initiation as Cancer Therapeutics (English)

1 reference

28 November 2024

author name string

Lisa Lindqvist

1

1 reference

24 August 2017

Jerry Pelletier

2

1 reference

24 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21425987

28 November 2024

publication date

1 December 2009

1 reference

24 August 2017

December 2009

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21425987

full work available at URL

28 November 2024

https://www.tandfonline.com/doi/pdf/10.4155/fmc.09.122

1 reference

Future Medicinal Chemistry

28 November 2024

published in

1 reference

24 August 2017

volume

1

1 reference

24 August 2017

issue

9

1 reference

24 August 2017

page(s)

1709-1722

1 reference

The molecular mechanics of eukaryotic translation

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins in initiation complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Dead-box proteins: a family affair--active and passive players in RNP-remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Selective pharmacological targeting of a DEAD box RNA helicase.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Further characterization of the helicase activity of eIF4A. Substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Interactions between eIF4AI and its accessory factors eIF4B and eIF4H

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Protein synthesis rates in colon and liver: stimulation by gastrointestinal pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Individual overexpression of five subunits of human translation initiation factor eIF3 promotes malignant transformation of immortal fibroblast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Identification of a 170-kDa protein over-expressed in lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: effect of mRNA 5' secondary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Positive and negative effects of the major mammalian messenger ribonucleoprotein p50 on binding of 40 S ribosomal subunits to the initiation codon of beta-globin mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Diminished Sensitivity of Re-initiation of Translation to Inhibition by Cap Analogues in Reticulocyte Lysates

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Targeting the eukaryotic translation initiation factor 4E for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Significance of eIF4E expression in skin squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Clinical Outcome in Stage I to III Breast Carcinoma and eIF4E Overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Targeting the mTOR signaling network for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cellsin vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Gene expression profiling of precursor T-cell lymphoblastic leukemia/lymphoma identifies oncogenic pathways that are potential therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Crystal structure of the eIF4A-PDCD4 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Structural basis for inhibition of translation by the tumor suppressor Pdcd4.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Structural basis for translational inhibition by the tumour suppressor Pdcd4

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Akt phosphorylates and regulates Pdcd4 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Pre-mRNA splicing: awash in a sea of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Total synthesis of the potent anticancer Aglaia metabolites (-)-silvestrol and (-)-episilvestrol and the active analogue (-)-4'-desmethoxyepisilvestrol.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Enantioselective synthesis of the complex rocaglate (-)-silvestrol

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Total Synthesis of (−)-Episilvestrol and (−)-Silvestrol

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Dissecting eIF4E action in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Mcl-1 is a relevant therapeutic target in acute and chronic lymphoid malignancies: down-regulation enhances rituximab-mediated apoptosis and complement-dependent cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Reduction of translation initiation factor 4E decreases the malignancy of ras -transformed cloned rat embryo fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

The proto-oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.122

HIPPURISTANOLS, CYTOTOXIC POLYOXYGENATED STEROIDS FROM THE GORGONIANISIS HIPPURIS

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1246/CL.1981.1647

eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure

8

1 reference

Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F

28 November 2024

9

1 reference

Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A

28 November 2024

14

1 reference

Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap-complex function

28 November 2024

21

1 reference

Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocytic and colonic epithelial neoplasms

28 November 2024

34

1 reference

Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor

28 November 2024

39

1 reference

mRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E

28 November 2024

41

1 reference

Translational enhancement of FGF-2 by eIF-4 factors, and alternate utilization of CUG and AUG codons for translation initiation.

28 November 2024

48

1 reference

Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: implications for tumor angiogenesis

28 November 2024

49

1 reference

Regulation of ornithine decarboxylase in a transformed cell line that overexpresses translation initiation factor eIF-4E.

28 November 2024

51

1 reference

Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma

28 November 2024

65

1 reference

Expression of eukaryotic translation initiation factors 4E and 2alpha is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung

28 November 2024

68

1 reference

Expression of mTOR signaling pathway markers in prostate cancer progression

28 November 2024

73

1 reference

Enhanced expression of translation factor mRNAs in hepatocellular carcinoma.

28 November 2024

77

1 reference

Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer

28 November 2024

87

1 reference

Alterations in the expression of PDCD4 in ductal carcinoma of the breast.

28 November 2024

88

1 reference

Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma.

28 November 2024

89

1 reference

Homogenous time resolved fluorescence assay to identify modulators of cap-dependent translation initiation

28 November 2024

98

1 reference

New cytotoxic steroids from the gorgonian Isis hippuris . Structure–activity studies

28 November 2024

101

1 reference

Expeditious synthesis of hippuristanol and congeners with potent antiproliferative activities

28 November 2024

102

1 reference

Pateamine: a potent cytotoxin from the New Zealand Marine sponge, mycale sp.

28 November 2024

105

1 reference

RNA-Mediated Sequestration of the RNA Helicase eIF4A by Pateamine A Inhibits Translation Initiation

28 November 2024

110

1 reference

Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells

28 November 2024

124

1 reference

Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis

28 November 2024

126

1 reference

Immunohistochemical analysis of Bcl-2, Bax, Bcl-X, and Mcl-1 expression in pancreatic cancers

28 November 2024

133

1 reference

Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma

28 November 2024

134

1 reference

Overexpression of anti-apoptotic Mcl-1 in testicular germ cell tumours

28 November 2024

135

1 reference

Silvestrol regulates G2/M checkpoint genes independent of p53 activity.

28 November 2024

137

1 reference

Silvestrol, a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in LNCaP cells through the mitochondrial/apoptosome pathway without activation of executioner caspase-3 or -7.

28 November 2024

138

1 reference

High-throughput assays probing protein-RNA interactions of eukaryotic translation initiation factors

28 November 2024

139

1 reference

28 November 2024

Identifiers

DOI

10.4155/FMC.09.122

1 reference

24 August 2017

1 reference