Acute promyelocytic leukaemia: novel insights into the mechanisms of cure (Q37802188)

23 August 2017

title

Acute promyelocytic leukaemia: novel insights into the mechanisms of cure (English)

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23 August 2017

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1

Hugues de Thé

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author name string

Zhu Chen

series ordinal

2

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23 August 2017

language of work or name

English

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publication date

22 October 2010

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23 August 2017

published in

Nature Reviews Cancer

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23 August 2017

volume

10

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23 August 2017

issue

11

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23 August 2017

page(s)

775-783

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PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation

23 August 2017

cites work

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SUMO association with repressor complexes, emerging routes for transcriptional control.

21 January 2018

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Acute promyelocytic leukemia

21 January 2018

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Acute promyelocytic leukemia: from highly fatal to highly curable

31 March 2020

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Tretinoin with chemotherapy in newly diagnosed acute promyelocytic leukaemia. European APL Group

31 March 2020

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Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome

31 March 2020

1 reference

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

31 March 2020

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Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

31 March 2020

1 reference

An efficient therapeutic approach to patients with acute promyelocytic leukemia using a combination of arsenic trioxide with low-dose all-trans retinoic acid

31 March 2020

1 reference

All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia

31 March 2020

1 reference

Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia

31 March 2020

1 reference

Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin

31 March 2020

1 reference

The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation

31 March 2020

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

31 March 2020

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

31 March 2020

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Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17

31 March 2020

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The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

31 March 2020

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Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations

31 March 2020

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Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.

31 March 2020

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Expression of T-lineage-affiliated transcripts and TCR rearrangements in acute promyelocytic leukemia: implications for the cellular target of t(15;17).

31 March 2020

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Mixed lineage leukemia translocations and a leukemia stem cell program

31 March 2020

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Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series.

31 March 2020

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In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia

31 March 2020

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A novel differentiation-inducing therapy for acute promyelocytic leukemia with a combination of arsenic trioxide and GM-CSF.

31 March 2020

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Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma

31 March 2020

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Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

31 March 2020

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Leukocytosis and the retinoic acid syndrome in patients with acute promyelocytic leukemia treated with arsenic trioxide

31 March 2020

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Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: durable remissions with minimal toxicity

31 March 2020

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Treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and/or chemotherapy

31 March 2020

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Single-agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia: long-term follow-up data

31 March 2020

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Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

31 March 2020

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Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers.

31 March 2020

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Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

31 March 2020

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Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

31 March 2020

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Positive and negative regulation of granulopoiesis by endogenous RARalpha

31 March 2020

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Reconstructing a disease: What essential features of the retinoic acid receptor fusion oncoproteins generate acute promyelocytic leukemia?

31 March 2020

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In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.

31 March 2020

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Forced retinoic acid receptor alpha homodimers prime mice for APL-like leukemia

31 March 2020

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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

31 March 2020

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A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest

31 March 2020

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RXR is an essential component of the oncogenic PML/RARA complex in vivo

31 March 2020

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Recruitment of RXR by Homotetrameric RARα Fusion Proteins Is Essential for Transformation

31 March 2020

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PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter

31 March 2020

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PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.

31 March 2020

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Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

31 March 2020

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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

31 March 2020

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RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

31 March 2020

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Down-regulation of RXR expression is essential for neutrophil development from granulocyte/monocyte progenitors

31 March 2020

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PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia

31 March 2020

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A sumoylation site in PML/RARA is essential for leukemic transformation.

31 March 2020

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Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

31 March 2020

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Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen.

31 March 2020

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Daxx: death or survival protein?

31 March 2020

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Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).

31 March 2020

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The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

31 March 2020

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Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.

31 March 2020

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Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7

31 March 2020

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A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters

31 March 2020

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Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways

31 March 2020

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Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

31 March 2020

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The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

31 March 2020

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Stem cell regulation by polycomb repressors: postponing commitment

31 March 2020

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The role of PML in tumor suppression

31 March 2020

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Regulation of apoptosis by PML and the PML-NBs.

31 March 2020

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PML nuclear bodies and apoptosis

31 March 2020

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PML targeting eradicates quiescent leukaemia-initiating cells

31 March 2020

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The tumor suppressor Pml regulates cell fate in the developing neocortex

31 March 2020

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PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool

31 March 2020

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The transcriptional role of PML and the nuclear body

31 March 2020

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The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

31 March 2020

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Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

31 March 2020

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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

31 March 2020

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Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

31 March 2020

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

31 March 2020

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Identification of a tumour suppressor network opposing nuclear Akt function

31 March 2020

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The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

31 March 2020

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Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia

31 March 2020

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Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins

31 March 2020

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Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission

31 March 2020

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Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure

31 March 2020

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Curing APL: differentiation or destruction?

31 March 2020

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Acute promyelocytic leukemia--weapons of mass differentiation

31 March 2020

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Neutrophil elastase cleaves PML-RARalpha and is important for the development of acute promyelocytic leukemia in mice

31 March 2020

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Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

31 March 2020

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Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation

31 March 2020

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PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.

31 March 2020

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Classification of heavy-metal toxicity by human DNA microarray analysis

31 March 2020

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Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

31 March 2020

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The mechanisms of PML-nuclear body formation

31 March 2020

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The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice

31 March 2020

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Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

31 March 2020

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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

31 March 2020

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RAR-independent RXR signaling induces t(15;17) leukemia cell maturation

31 March 2020

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Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor

31 March 2020

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Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia

31 March 2020

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Two critical hits for promyelocytic leukemia

31 March 2020

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PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

31 March 2020

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Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.

31 March 2020

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How acute promyelocytic leukaemia revived arsenic

31 March 2020

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Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia

31 March 2020

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Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

31 March 2020

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Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo

31 March 2020

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Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells.

31 March 2020

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Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

31 March 2020

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Role of the histone deacetylase complex in acute promyelocytic leukaemia

31 March 2020

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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

31 March 2020

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Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

31 March 2020

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Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC

31 March 2020

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Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient

31 March 2020

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Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies

31 March 2020

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RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia

31 March 2020

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How I treat acute promyelocytic leukemia

31 March 2020

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Arsenic patent keeps drug for rare cancer out of reach of many

31 March 2020

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Function of RARalpha during the maturation of neutrophils

31 March 2020

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PML is essential for multiple apoptotic pathways

31 March 2020

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A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia

31 March 2020

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Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL).

31 March 2020

1 reference

The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells

31 March 2020

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Acute promyelocytic leukaemia in patients originating in Latin America is associated with an increased frequency of the bcr1 subtype of the PML/RARalpha fusion gene.

31 March 2020

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The induction of differentiation in teratocarcinoma stem cells by retinoic acid

31 March 2020

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Cancer stem cells: lessons from leukemia.

31 March 2020

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A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

31 March 2020

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Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

31 March 2020

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High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARα expression

31 March 2020

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GVHD therapy: let there be light!

31 March 2020

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Pharicin B stabilizes retinoic acid receptor-α and presents synergistic differentiation induction with ATRA in myeloid leukemic cells

31 March 2020

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12 December 2020

Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).

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12 December 2020

Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia

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12 December 2020

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

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12 December 2020

Terminal differentiation of human promyelocytic leukemic cells in primary culture in response to retinoic acid

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12 December 2020

All-trans-retinoic acid as a differentiating agent in the treatment of acute promyelocytic leukemia.

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12 December 2020

Long-term survival and prognostic study in acute promyelocytic leukemia treated with all-trans-retinoic acid, chemotherapy, and As2O3: an experience of 120 patients at a single institution

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12 December 2020

Leukemia initiated by PMLRARalpha: the PML domain plays a critical role while retinoic acid-mediated transactivation is dispensable

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12 December 2020

Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein

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12 December 2020

Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk

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12 December 2020

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells

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12 December 2020

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia

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12 December 2020

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results

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12 December 2020

Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro.

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12 December 2020

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12 December 2020

Retinoic acid and arsenic: towards oncogene-targeted treatments of acute promyelocytic leukaemia

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12 December 2020

Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group

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12 December 2020

All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship.

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12 December 2020

cAMP signalling is decisive for recovery of nuclear bodies (PODs) during maturation of RA-resistant t(15;17) promyelocytic leukemia NB4 cells expressing PML-RAR alpha

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12 December 2020

Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710.

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12 December 2020

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

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12 December 2020

Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia

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12 December 2020

Establishment of a human acute promyelocytic leukemia-ascites model in SCID mice.

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12 December 2020

Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1

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12 December 2020

Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein

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12 December 2020

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion

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12 December 2020

The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

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12 December 2020

Arsenic-interferon-alpha-triggered apoptosis in HTLV-I transformed cells is associated with tax down-regulation and reversal of NF-kappa B activation.

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12 December 2020

A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia

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12 December 2020

Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences

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12 December 2020

AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor

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12 December 2020

Overexpression of wild-type retinoic acid receptor alpha (RARalpha) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARalpha-fusion genes.

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12 December 2020

PML protein expression in hematopoietic and acute promyelocytic leukemia cells

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12 December 2020

Identifiers

DOI

10.1038/NRC2943

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23 August 2017

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