Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis (Q37721838)

22 August 2017

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title

Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis (English)

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22 August 2017

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2

Young-Joon Surh

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22 August 2017

Joydeb Kumar Kundu

1

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22 August 2017

publication date

31 March 2010

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22 August 2017

published in

Pharmaceutical Research

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22 August 2017

volume

27

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22 August 2017

issue

6

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22 August 2017

page(s)

999-1013

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Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis

22 August 2017

cites work

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Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer

21 January 2018

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Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans.

21 January 2018

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Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice

21 January 2018

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Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.

21 January 2018

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Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes

21 January 2018

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Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus.

21 January 2018

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Adenoviral gene delivery of elafin and secretory leukocyte protease inhibitor attenuates NF-kappa B-dependent inflammatory responses of human endothelial cells and macrophages to atherogenic stimuli

21 January 2018

1 reference

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Dietary curcumin enhances benzo(a)pyrene-induced apoptosis resulting in a decrease in BPDE-DNA adducts in mice

21 January 2018

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Nrf2 signaling in coordinated activation of antioxidant gene expression

21 January 2018

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12 December 2020

Antioxidants and oxidants regulated signal transduction pathways

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12 December 2020

Regulation of lipopolysaccharide-induced inflammatory response by glutathione S-transferase P1 in RAW264.7 cells

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12 December 2020

Anti-tumor promoting action of phthalic acid mono-n-butyl ester cupric salt, a biomimetic superoxide dismutase

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12 December 2020

Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases

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12 December 2020

Cellular mucosal defense during Helicobacter pylori infection: a review of the role of glutathione and the oxidative pentose pathway

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12 December 2020

Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway

1 reference

12 December 2020

NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities

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12 December 2020

Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice

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12 December 2020

8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure

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12 December 2020

Heme oxygenase-1 inhibits cytokine production by activated mast cells

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12 December 2020

Protective effect of glutathione against lipopolysaccharide-induced inflammation and mortality in rats

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12 December 2020

Influence of Nrf2 genotype on pulmonary NF-kappaB activity and inflammatory response after traumatic brain injury.

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12 December 2020

Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway

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12 December 2020

Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury

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12 December 2020

Oxidative DNA damage: mechanisms, mutation, and disease

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12 December 2020

Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema

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12 December 2020

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

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12 December 2020

The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis

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12 December 2020

Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model.

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12 December 2020

Glutamine reduces TNF-alpha by enhancing glutathione synthesis in lipopolysaccharide-stimulated alveolar epithelial cells of rats

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12 December 2020

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

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12 December 2020

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

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12 December 2020

Aberrant mucosal wound repair in the absence of secretory leukocyte protease inhibitor

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12 December 2020

Disruption of c-Fos leads to increased expression of NAD(P)H:quinone oxidoreductase1 and glutathione S-transferase

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12 December 2020

Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats

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12 December 2020

Carbon monoxide signalling reduces photocarcinogenesis in the hairless mouse

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12 December 2020

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

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12 December 2020

8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis

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12 December 2020

Inflammation: gearing the journey to cancer

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12 December 2020

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

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12 December 2020

Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems

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12 December 2020

Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation

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12 December 2020

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

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12 December 2020

Cancer chemoprevention with dietary phytochemicals

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12 December 2020

15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells

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12 December 2020

Oxidative stress and ulcerative colitis-associated carcinogenesis: studies in humans and animal models

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12 December 2020

Analysis of intestinal haem-oxygenase-1 (HO-1) in clinical and experimental colitis

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12 December 2020

The role of 15-deoxy-delta(12,14)-prostaglandin J(2), an endogenous ligand of peroxisome proliferator-activated receptor gamma, in tumor angiogenesis

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12 December 2020

Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species

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12 December 2020

Low and high dose UVB regulation of transcription factor NF-E2-related factor 2.

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12 December 2020

Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice

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12 December 2020

Critical role of endogenous heme oxygenase 1 as a tuner of the invasive potential of prostate cancer cells

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12 December 2020

Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model

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12 December 2020

Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro.

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12 December 2020

Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice

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12 December 2020

NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis

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12 December 2020

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

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12 December 2020

Inducible cyclooxygenase-derived 15-deoxyΔ12-14PGJ2 brings about acute inflammatory resolution in rat pleurisy by inducing neutrophil and macrophage apoptosis

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12 December 2020

Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation

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12 December 2020

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

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12 December 2020

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

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12 December 2020

Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages

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12 December 2020

At the crossroads of inflammation and cancer

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12 December 2020

Regulation of JNK signaling by GSTp

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12 December 2020

Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice

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12 December 2020

Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment

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12 December 2020

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

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12 December 2020

NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin

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12 December 2020

Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer

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12 December 2020

Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

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12 December 2020

Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

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12 December 2020

Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis

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12 December 2020

15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS.

1 reference

12 December 2020

Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs

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12 December 2020

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

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12 December 2020

Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice

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12 December 2020

Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice

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12 December 2020

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

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12 December 2020

Nrf2 as a novel molecular target for chemoprevention

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12 December 2020

Colorectal cancer prevention in ulcerative colitis: a case-control study.

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12 December 2020

Cellular and molecular pathways linking inflammation and cancer

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12 December 2020

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

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12 December 2020

Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

1 reference

12 December 2020

Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide

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12 December 2020

Lactobacillus fermentum, a probiotic capable to release glutathione, prevents colonic inflammation in the TNBS model of rat colitis

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12 December 2020

Inflammatory cytokines suppress NAD(P)H:quinone oxidoreductase-1 and induce oxidative stress in cholangiocarcinoma cells.

1 reference

12 December 2020

Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study

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12 December 2020

Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis

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12 December 2020

Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress

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12 December 2020

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

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12 December 2020

Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells

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12 December 2020

Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.

1 reference

12 December 2020

Molecular mechanisms of Nrf2-mediated antioxidant response

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12 December 2020

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12 December 2020

Sulforaphane suppresses LPS-induced inflammation in primary rat microglia

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12 December 2020

Colonic expression of heme oxygenase-1 is associated with a better long-term survival in patients with colorectal cancer

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12 December 2020

Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase

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12 December 2020

Increased intestinal inflammatory response and gut barrier dysfunction in Nrf2-deficient mice after traumatic brain injury

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12 December 2020

Overexpression of HO-1 protects against TNF-alpha-mediated airway inflammation by down-regulation of TNFR1-dependent oxidative stress

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12 December 2020

Mechanistic studies of the Nrf2-Keap1 signaling pathway

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12 December 2020

Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.

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12 December 2020

Human thioredoxin-1 ameliorates experimental murine colitis in association with suppressed macrophage inhibitory factor production.

1 reference

12 December 2020

Secretory leukoprotease inhibitor: partnering alpha 1-proteinase inhibitor to combat pulmonary inflammation

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12 December 2020

Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)

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12 December 2020

Role of 15-deoxy delta(12,14) prostaglandin J2 and Nrf2 pathways in protection against acute lung injury.

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12 December 2020

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

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12 December 2020

Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases

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12 December 2020

Manganese superoxide dismutase expression inhibits soft agar growth in JB6 clone41 mouse epidermal cells

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12 December 2020

Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression

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12 December 2020

A free radical mediated cooxidation of tetramethylhydrazine by prostaglandin hydroperoxidase

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12 December 2020

Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma

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12 December 2020

Chronic inflammation: a common and important factor in the pathogenesis of neoplasia

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12 December 2020

Oxyradicals and DNA damage

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12 December 2020

Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halide-dependent formation of hydroxyl radical

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12 December 2020

Inflammation and cancer: an ancient link with novel potentials.

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12 December 2020

Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing

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12 December 2020

Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation

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12 December 2020

Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis.

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12 December 2020

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

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12 December 2020

Human glutathione S-transferase P1 suppresses MEKK1-mediated apoptosis by regulating MEKK1 kinase activity in HEK293 cells.

1 reference

12 December 2020

Effects of carbon monoxide releasing molecule-liberated CO on severe acute pancreatitis in rats

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12 December 2020

The Multistage Theory of Carcinogenesis and the Age Distribution of Cancer in Man2

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12 December 2020

Immunohistochemical analysis of heme oxygenase-1 in preneoplastic and neoplastic lesions during chemical hepatocarcinogenesis

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12 December 2020

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation

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12 December 2020

Recombinant protein glutathione S-transferases P1 attenuates inflammation in mice

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12 December 2020

The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in Caco-2 cells.

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12 December 2020

10.1007/S11095-010-0096-8

Identifiers

DOI

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22 August 2017

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