Repeat instability as the basis for human diseases and as a potential target for therapy (Q37696952)

22 August 2017

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title

Repeat instability as the basis for human diseases and as a potential target for therapy (English)

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22 August 2017

Arturo López Castel

1

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22 August 2017

John D Cleary

series ordinal

2

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22 August 2017

Christopher E Pearson

series ordinal

3

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22 August 2017

publication date

1 March 2010

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Nature Reviews Molecular Cell Biology

22 August 2017

published in

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22 August 2017

volume

11

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22 August 2017

issue

3

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22 August 2017

page(s)

165-170

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Repeat instability: mechanisms of dynamic mutations

22 August 2017

cites work

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DNA instability in postmitotic neurons

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ATM and ATR protect the genome against two different types of tandem repeat instability in Fragile X premutation mice

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31 March 2020

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Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms.

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31 March 2020

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(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition

31 March 2020

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MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice

31 March 2020

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Mutagenic roles of DNA "repair" proteins in antibody diversity and disease-associated trinucleotide repeat instability

31 March 2020

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Incision-dependent and error-free repair of (CAG)(n)/(CTG)(n) hairpins in human cell extracts

31 March 2020

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Slipped (CTG)*(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair

31 March 2020

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31 March 2020

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Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion.

31 March 2020

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Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice

31 March 2020

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31 March 2020

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CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease

31 March 2020

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Transcription promotes contraction of CAG repeat tracts in human cells

31 March 2020

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R loops stimulate genetic instability of CTG.CAG repeats

31 March 2020

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31 March 2020

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An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals

31 March 2020

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SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination

31 March 2020

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CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination

31 March 2020

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The Friedreich ataxia GAA repeat expansion mutation induces comparable epigenetic changes in human and transgenic mouse brain and heart tissues

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Expandable DNA repeats and human disease.

31 March 2020

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A persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitro

31 March 2020

1 reference

Variant CCG and GGC repeats within the CTG expansion dramatically modify mutational dynamics and likely contribute toward unusual symptoms in some myotonic dystrophy type 1 patients

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20177394

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM2854

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22 August 2017

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