Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells. (Q37643235)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26953160%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells (English)

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10 March 2020

1 reference

1 reference

1

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10 March 2020

Terri C Thayer

2

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10 March 2020

James E McLaren

3

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10 March 2020

Kristin Ladell

4

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10 March 2020

Dimitri Kakabadse

8

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10 March 2020

David A Price

12

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10 March 2020

F. Susan Wong

13

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10 March 2020

author name string

Evy De Leenheer

5

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10 March 2020

Amy Phillips

6

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10 March 2020

Joanne Davies

7

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10 March 2020

Kelly Miners

9

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10 March 2020

Peter Morgan

10

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10 March 2020

Li Wen

11

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10 March 2020

language of work or name

English

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publication date

7 March 2016

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10 March 2020

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10 March 2020

volume

65

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10 March 2020

issue

6

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10 March 2020

page(s)

1679-1689

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Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide

10 March 2020

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23 August 2017

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23 August 2017

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

23 August 2017

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Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses

23 August 2017

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

23 August 2017

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Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

23 August 2017

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Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

23 August 2017

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A structural basis for immunodominant human T cell receptor recognition

23 August 2017

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Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

23 August 2017

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Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood

23 August 2017

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23 August 2017

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23 August 2017

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Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus

23 August 2017

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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

23 August 2017

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23 August 2017

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CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

23 August 2017

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23 August 2017

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23 August 2017

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28 September 2017

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28 September 2017

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25 June 2018

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25 June 2018

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25 June 2018

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Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity.

25 June 2018

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Autoimmunity to both proinsulin and IGRP is required for diabetes in nonobese diabetic 8.3 TCR transgenic mice.

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1 September 2018

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

1 September 2018

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Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

1 September 2018

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Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self

1 September 2018

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Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

3 December 2018

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Immunotargeting of insulin reactive CD8 T cells to prevent diabetes

3 December 2018

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12 December 2020

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

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12 December 2020

Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice

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12 December 2020

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

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12 December 2020

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

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12 December 2020

Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones

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12 December 2020

Identifiers

DOI

10.2337/DB15-1498

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26953160%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26953160%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

26953160

1 reference