Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. (Q37587875)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

review article

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title

Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

2

Detlef Schuppan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

English

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publication date

1 October 2009

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6 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

50

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

4

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6 February 2020

page(s)

1294-1306

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6 February 2020

1 reference

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Reversal of hepatic fibrosis -- fact or fantasy?

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7 January 2021

Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

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7 January 2021

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

1 reference

7 January 2021

Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications

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7 January 2021

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7 January 2021

Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis

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7 January 2021

Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice

1 reference

7 January 2021

Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro

1 reference

7 January 2021

Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

1 reference

7 January 2021

Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis

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7 January 2021

Oval cell numbers in human chronic liver diseases are directly related to disease severity.

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7 January 2021

Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis

1 reference

7 January 2021

Pathophysiology of the intrahepatic biliary epithelium

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Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression

1 reference

7 January 2021

Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis.

1 reference

7 January 2021

The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.

1 reference

7 January 2021

A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis

1 reference

7 January 2021

Gene expression profiles during hepatic stellate cell activation in culture and in vivo

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7 January 2021

Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.

1 reference

7 January 2021

Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

1 reference

7 January 2021

Hedgehog-mediated mesenchymal–epithelial interactions modulate hepatic response to bile duct ligation

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7 January 2021

Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth

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7 January 2021

Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases

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7 January 2021

Fibrogenic cell fate during fibrotic tissue remodelling observed in rat and human cultured liver slices

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Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu

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Microscale culture of human liver cells for drug development

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Microscale control of cell contact and spacing via three-component surface patterning

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Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes

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7 January 2021

A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis

1 reference

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Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15.

1 reference

7 January 2021

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis.

1 reference

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Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice

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Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis

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Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis

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Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

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Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis

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Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice

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Antifibrotic therapy in chronic liver disease

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In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis

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Development of TGF-beta signalling inhibitors for cancer therapy

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Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

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Role of alphavbeta6 integrin in acute biliary fibrosis

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7 January 2021

Herbal products for liver diseases: a therapeutic challenge for the new millennium

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7 January 2021

Complementary and alternative medicine in hepatology: review of the evidence of efficacy

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Herbal hepatotoxicity

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Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.

1 reference

7 January 2021

Drug repositioning: identifying and developing new uses for existing drugs

1 reference

7 January 2021

Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis

1 reference

7 January 2021

Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.

1 reference

7 January 2021

Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.

1 reference

7 January 2021

Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats

1 reference

7 January 2021

Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats.

1 reference

7 January 2021

Imatinib mesylate (STI-571) attenuates liver fibrosis development in rats.

1 reference

7 January 2021

The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue

1 reference

7 January 2021

Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell.

1 reference

7 January 2021

Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers.

1 reference

7 January 2021

Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury.

1 reference

7 January 2021

Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone

1 reference

7 January 2021

PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells

1 reference

7 January 2021

1 reference

7 January 2021

Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection

1 reference

7 January 2021

Sampling variability of liver fibrosis in chronic hepatitis C.

1 reference

7 January 2021

Sampling variability of percutaneous liver biopsy in primary sclerosing cholangitis

1 reference

7 January 2021

Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease

1 reference

7 January 2021

Hepatic stellate cell activation in liver transplant patients with hepatitis C recurrence and in non-transplanted patients with chronic hepatitis C.

1 reference

7 January 2021

Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis

1 reference

7 January 2021

Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis.

1 reference

7 January 2021

Technology Insight: noninvasive assessment of liver fibrosis by biochemical scores and elastography.

1 reference

7 January 2021

Diagnosis and quantitation of fibrosis

1 reference

7 January 2021

Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers

1 reference

7 January 2021

Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin

1 reference

7 January 2021

Estimation of stage-specific fibrosis progression rates in chronic hepatitis C virus infection: a meta-analysis and meta-regression

1 reference

7 January 2021

Exceeding the limits of liver histology markers

1 reference

7 January 2021

Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.

1 reference

7 January 2021

An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load

1 reference

7 January 2021

Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease

1 reference

7 January 2021

Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay

1 reference

7 January 2021

Longitudinal evaluation of a fibrosis index combining MMP-1 and PIIINP compared with MMP-9, TIMP-1 and hyaluronic acid in patients with chronic hepatitis C treated by interferon-alpha and ribavirin

1 reference

7 January 2021

Progression of fibrosis in hepatitis C with and without schistosomiasis: Correlation with serum markers of fibrosis

1 reference

7 January 2021

Higher dimensional (Hi-D) separation strategies dramatically improve the potential for cancer biomarker detection in serum and plasma

1 reference

7 January 2021

The role of electrophoresis in disease biomarker discovery

1 reference

7 January 2021

Proteomics: the first decade and beyond

1 reference

7 January 2021

Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients

1 reference

7 January 2021

Liver Gene Expression Signature of Mild Fibrosis in Patients With Chronic Hepatitis C

1 reference

7 January 2021

Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications

1 reference

7 January 2021

Computer-aided diagnosis of hepatic fibrosis: preliminary evaluation of MRI texture analysis using the finite difference method and an artificial neural network

1 reference

7 January 2021

Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging

1 reference

7 January 2021

Functional magnetic resonance imaging monitoring of pathological changes in rodent livers during hyperoxia and hypercapnia

1 reference

7 January 2021

Transient elastography: a new noninvasive method for assessment of hepatic fibrosis.

1 reference

7 January 2021

Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study

1 reference

7 January 2021

Performance of transient elastography for the staging of liver fibrosis: a meta-analysis

1 reference

7 January 2021

Non-invasive evaluation of liver fibrosis using transient elastography

1 reference

7 January 2021

Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases

1 reference

7 January 2021

Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C

1 reference

7 January 2021

Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis

1 reference

7 January 2021

MR elastography of liver fibrosis: preliminary results comparing spin-echo and echo-planar imaging.

1 reference

7 January 2021

Magnetic resonance elastography for the noninvasive staging of liver fibrosis.

1 reference

7 January 2021

New technologies for human cancer imaging

1 reference

7 January 2021

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

1 reference

7 January 2021

Attenuated liver fibrosis in the absence of B cells

1 reference

7 January 2021

Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners

1 reference

7 January 2021

Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes

1 reference

7 January 2021

The bone marrow functionally contributes to liver fibrosis

1 reference

7 January 2021

Interstrain differences in susceptibility to non-alcoholic steatohepatitis

1 reference

7 January 2021

An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis

1 reference

7 January 2021

CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis

1 reference

7 January 2021

TLR4 enhances TGF-beta signaling and hepatic fibrosis

1 reference

7 January 2021

The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse

1 reference

7 January 2021

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

1 reference

7 January 2021

Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha1(I) and TIMP-1

1 reference

7 January 2021

Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats

1 reference

7 January 2021

Prevention of liver cirrhosis in rats by curcumin

1 reference

7 January 2021

Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats

1 reference

7 January 2021

Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats

1 reference

7 January 2021

Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors

1 reference

7 January 2021

Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats

1 reference

7 January 2021