Inhibition of RAS function through targeting an allosteric regulatory site. (Q37540897)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

Inhibition of RAS function through targeting an allosteric regulatory site (English)

1 reference

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26 March 2020

4

1 reference

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26 March 2020

Matthew J. Smith

13

1 reference

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26 March 2020

Mitsuhiko Ikura

22

1 reference

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26 March 2020

John P O'Bryan

24

1 reference

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26 March 2020

author name string

Russell Spencer-Smith

1

1 reference

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26 March 2020

Akiko Koide

2

1 reference

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26 March 2020

Yong Zhou

3

1 reference

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26 March 2020

Fern Sha

5

1 reference

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26 March 2020

Priyanka Gajwani

6

1 reference

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26 March 2020

Dianicha Santana

7

1 reference

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26 March 2020

Ankit Gupta

8

1 reference

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26 March 2020

Miranda Jacobs

9

1 reference

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26 March 2020

Erika Herrero-Garcia

10

1 reference

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26 March 2020

Jacqueline Cobbert

11

1 reference

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26 March 2020

Hugo Lavoie

12

1 reference

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26 March 2020

Thanashan Rajakulendran

15

1 reference

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26 March 2020

Evan Dowdell

16

1 reference

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26 March 2020

Mustafa Nazir Okur

17

1 reference

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26 March 2020

Irina Dementieva

18

1 reference

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26 March 2020

Frank Sicheri

19

1 reference

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26 March 2020

Marc Therrien

20

1 reference

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26 March 2020

John F Hancock

21

1 reference

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26 March 2020

Shohei Koide

23

1 reference

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26 March 2020

Matthew Smith

14

1 reference

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26 March 2020

publication date

7 November 2016

1 reference

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26 March 2020

published in

Nature Chemical Biology

1 reference

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26 March 2020

volume

13

1 reference

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26 March 2020

issue

1

1 reference

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26 March 2020

page(s)

62-68

1 reference

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describes a project that uses

26 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5193369/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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23 August 2017

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Inhibition of Ras-Effector Interaction by Cyclic Peptides

23 August 2017

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Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling

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23 August 2017

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

23 August 2017

1 reference

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Target-binding proteins based on the 10th human fibronectin type III domain (¹⁰Fn3).

23 August 2017

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Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

23 August 2017

1 reference

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An orthosteric inhibitor of the Ras-Sos interaction

23 August 2017

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Ras history: The saga continues

23 August 2017

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Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design

23 August 2017

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

23 August 2017

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

23 August 2017

1 reference

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A dimerization-dependent mechanism drives RAF catalytic activation

23 August 2017

1 reference

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Phasercrystallographic software

23 August 2017

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23 August 2017

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Electrostatic interactions positively regulate K-Ras nanocluster formation and function

23 August 2017

1 reference

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A novel switch region regulates H-ras membrane orientation and signal output

23 August 2017

1 reference

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23 August 2017

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23 August 2017

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Human RAS superfamily proteins and related GTPases

23 August 2017

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

23 August 2017

1 reference

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Direct visualization of Ras proteins in spatially distinct cell surface microdomains

23 August 2017

1 reference

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The structural basis for the transition from Ras-GTP to Ras-GDP

23 August 2017

1 reference

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Vav2 is an activator of Cdc42, Rac1, and RhoA

23 August 2017

1 reference

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The fibronectin type III domain as a scaffold for novel binding proteins

23 August 2017

1 reference

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The structural basis of the activation of Ras by Sos

23 August 2017

1 reference

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The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

23 August 2017

1 reference

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Shape complementarity at protein/protein interfaces

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Rapid and efficient site-specific mutagenesis without phenotypic selection

23 August 2017

1 reference

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Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Formation of the Ras dimer is essential for Raf-1 activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor

28 September 2017

1 reference

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N-Ras forms dimers at POPC membranes

25 June 2018

1 reference

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Observing cell surface signaling domains using electron microscopy

25 June 2018

1 reference

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Oligomeric structure of p21 ras proteins as determined by radiation inactivation

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Ras signalling on the endoplasmic reticulum and the Golgi

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Nonradioactive determination of Ras-GTP levels using activated ras interaction assay

1 September 2018

1 reference

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A novel assay for the measurement of Raf-1 kinase activity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5193369

Constraint and turnover in sex-biased gene expression in the genus Drosophila

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2231

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27820802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

ProtorP: a protein-protein interaction analysis server

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27820802

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.2231

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27820802%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

27820802

1 reference