NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. (Q37452311)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Kiran Bhaskar

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Maria Z Kounnas

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Steven L Wagner

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Yan Yang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Bruce T Lamb

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Karl Herrup

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

9 November 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

12 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

119

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

12

1 reference

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12 February 2020

page(s)

3692-3702

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity

12 February 2020

cites work

1 reference

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Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death

23 August 2017

1 reference

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Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.

23 August 2017

1 reference

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Substrate-targeting gamma-secretase modulators

23 August 2017

1 reference

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Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

23 August 2017

1 reference

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Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib

23 August 2017

1 reference

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Protective effects of NSAIDs on the development of Alzheimer disease

23 August 2017

1 reference

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

23 August 2017

1 reference

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Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

23 August 2017

1 reference

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Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice

23 August 2017

1 reference

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

23 August 2017

1 reference

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Control of microglial neurotoxicity by the fractalkine receptor

23 August 2017

1 reference

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Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

23 August 2017

1 reference

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Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

23 August 2017

1 reference

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

23 August 2017

1 reference

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Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease

23 August 2017

1 reference

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NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

23 August 2017

1 reference

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Blood monocytes consist of two principal subsets with distinct migratory properties

23 August 2017

1 reference

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Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Inflammation and Alzheimer's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Mitotic mechanisms in Alzheimer's disease?

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Amyloid precursor protein in aged nonhuman primates

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Risk of Alzheimer's disease and duration of NSAID use.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

2009 Alzheimer's disease facts and figures

9 September 2017

1 reference

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Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

28 September 2017

1 reference

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Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

26 June 2018

1 reference

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Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

26 June 2018

1 reference

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Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs

26 June 2018

1 reference

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Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging.

26 June 2018

1 reference

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Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Imaging beta-amyloid burden in aging and dementia.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Quantitative morphological study of microglial cells in the ischemic rat brain using principal component analysis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Morphological development of microglia in the postnatal rat brain. A quantitative study

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Genetic background regulates -amyloid precursor protein processing and -amyloid deposition in the mouse

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Lower Counts of Astroglia and Activated Microglia in Patients with Alzheimer's Disease with Regular Use of Non-Steroidal Anti-Inflammatory Drugs

2 September 2018

1 reference

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Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts

2 September 2018

1 reference

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Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

2 September 2018

1 reference

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Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

2 September 2018

1 reference

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Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice

2 September 2018

1 reference

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

2 September 2018

1 reference

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DNA replication precedes neuronal cell death in Alzheimer's disease.

2 September 2018

1 reference

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Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576.

2 September 2018

1 reference

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Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods

2 September 2018

1 reference

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Mild cognitive impairment: transition between aging and Alzheimer's disease

2 September 2018

1 reference

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Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice

2 September 2018

1 reference

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Aging and Alzheimer's disease: lessons from the Nun Study.

2 September 2018

1 reference

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Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2786797

[11C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19907078

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19907078

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI39716

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19907078%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

19907078

1 reference