Calcitonin gene-related peptide receptor antagonists for the treatment of migraine (Q37425639)

20 August 2017

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title

Calcitonin gene-related peptide receptor antagonists for the treatment of migraine (English)

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20 August 2017

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Theresa M Williams

1

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20 August 2017

Christopher S Burgey

series ordinal

2

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20 August 2017

Christopher A Salvatore

series ordinal

3

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20 August 2017

language of work or name

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1 January 2009

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Progress in medicinal chemistry

20 August 2017

published in

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20 August 2017

volume

47

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20 August 2017

page(s)

1-35

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Migraine headaches: a historical prospective, a glimpse into the future, and migraine epidemiology

20 August 2017

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Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine

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Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin

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Randomized controlled trial of an oral CGRP receptor antagonist, MK-0974, in acute treatment of migraine

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Calcitonin gene-related peptide is a potent vasodilator

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7 January 2021

Distribution and effects of neuropeptide Y, vasoactive intestinal peptide, substance P, and calcitonin gene-related peptide in human middle meningeal arteries: Comparison with cerebral and temporal arteries

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7 January 2021

Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system

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Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

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Calcitonin gene-related peptide (CGRP) and migraine

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7 January 2021

The nonpeptide calcitonin gene-related peptide receptor antagonist BIBN4096BS lowers the activity of neurons with meningeal input in the rat spinal trigeminal nucleus.

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7 January 2021

Calcitonin gene-related peptide (CGRP) modulates nociceptive trigeminovascular transmission in the cat.

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7 January 2021

Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine

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Vasoactive Intestinal Peptide Causes Marked Cephalic Vasodilation, but does not Induce Migraine

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7 January 2021

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7 January 2021

CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors.

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7 January 2021

Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature

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7 January 2021

Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: differences between peripheral and central CGRP receptor distrib

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Neurogenic inflammation in the context of migraine

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7 January 2021

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Comparative distribution of receptors for amylin and the related peptides calcitonin gene related peptide and calcitonin in rat and monkey brain

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7 January 2021

Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors

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7 January 2021

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7 January 2021

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7 January 2021

Characterisation of the effects of a non-peptide CGRP receptor antagonist in SK-N-MC cells and isolated human cerebral arteries

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7 January 2021

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7 January 2021

Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists

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7 January 2021

CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS.

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7 January 2021

Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-r

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7 January 2021

Identification and pharmacological characterization of domains involved in binding of CGRP receptor antagonists to the calcitonin-like receptor

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7 January 2021

Investigation of the species selectivity of a nonpeptide CGRP receptor antagonist using a novel pharmacodynamic assay

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7 January 2021

Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation

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7 January 2021

Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-l-lysyl]-4-

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7 January 2021

The CGRP-antagonist, BIBN4096BS does not affect cerebral or systemic haemodynamics in healthy volunteers.

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7 January 2021

Effects of BIBN4096BS on cardiac output distribution and on CGRP-induced carotid haemodynamic responses in the pig.

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7 January 2021

Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead

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7 January 2021

Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.

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7 January 2021

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7 January 2021

Calcitonin gene-related peptide (CGRP) receptor antagonists: investigations of a pyridinone template

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7 January 2021

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7 January 2021

Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produce antagonists with increased affinity.

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7 January 2021

Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine

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7 January 2021

Caprolactams as potent CGRP receptor antagonists for the treatment of migraine

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7 January 2021

Synthesis of the (3R,6S)-3-amino-6-(2,3-difluorophenyl)azepan-2-one of telcagepant (MK-0974), a calcitonin gene-related peptide receptor antagonist for the treatment of migraine headache

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7 January 2021

Rhodium-catalyzed asymmetric 1,4-addition and its related asymmetric reactions

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7 January 2021

311C90 (Zolmitriptan), a novel centrally and peripheral acting oral 5-hydroxytryptamine-1D agonist: a comparison of its absorption during a migraine attack and in a migraine-free period.

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7 January 2021

Reproducibility of the capsaicin-induced dermal blood flow response as assessed by laser Doppler perfusion imaging

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7 January 2021

10.1016/S0079-6468(08)00201-4

Identifiers

DOI

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20 August 2017

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