Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control (Q37371666)

20 August 2017

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control (English)

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20 August 2017

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Deborah M Muoio

9

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author name string

Robert C Noland

1

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20 August 2017

Timothy R Koves

2

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20 August 2017

Sarah E Seiler

3

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20 August 2017

Helen Lum

4

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20 August 2017

Robert M Lust

5

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20 August 2017

Olga Ilkayeva

6

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20 August 2017

Robert D Stevens

7

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20 August 2017

Fausto G Hegardt

8

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20 August 2017

language of work or name

English

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publication date

24 June 2009

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20 August 2017

13

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Journal of Biological Chemistry

inferred from page(s)

published in

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20 August 2017

284

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20 August 2017

34

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20 August 2017

22840-22852

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describes a project that uses

20 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2755692/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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High-fat diets cause insulin resistance despite an increase in muscle mitochondria

6 September 2017

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PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis

6 September 2017

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Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.

6 September 2017

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

6 September 2017

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Substrate and functional diversity of lysine acetylation revealed by a proteomics survey

6 September 2017

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Disorders of carnitine transport and the carnitine cycle

6 September 2017

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6 September 2017

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Delaying the mitochondrial decay of aging with acetylcarnitine

6 September 2017

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Carnitine: transport and physiological functions in the brain.

6 September 2017

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Carnitine: a nutritional, biosynthetic, and functional perspective

6 September 2017

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Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes

6 September 2017

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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

6 September 2017

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Treatment of carnitine deficiency

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Carnitine transport: pathophysiology and metabolism of known molecular defects

6 September 2017

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6 September 2017

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Carnitine protects mitochondria and removes toxic acyls from xenobiotics

6 September 2017

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Artificial selection for intrinsic aerobic endurance running capacity in rats

6 September 2017

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L-carnitine improves glucose disposal in type 2 diabetic patients

6 September 2017

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Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups

6 September 2017

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Properties of purified carnitine acyltransferases of mouse liver peroxisomes

6 September 2017

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The substrate specificity of carnitine acetyltransferase

6 September 2017

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Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

6 September 2017

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Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

14 September 2017

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Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells.

14 September 2017

1 reference

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Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients.

14 September 2017

1 reference

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Equilibrium constants of the reactions of choline acetyltransferase, carnitine acetyltransferase, and acetylcholinesterase under physiological conditions

14 September 2017

1 reference

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Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells

14 September 2017

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epsilon-N-trimethyllysine availability regulates the rate of carnitine biosynthesis in the growing rat.

28 September 2017

1 reference

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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

28 September 2017

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Acetyl-L-carnitine protects against amyloid-beta neurotoxicity: roles of oxidative buffering and ATP levels

26 June 2018

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Diagnosis of very long chain acyl-dehydrogenase deficiency from an infant's newborn screening card

26 June 2018

1 reference

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Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis

26 June 2018

1 reference

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Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels

26 June 2018

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Effects of ciprofibrate and 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate (POCA) on the distribution of carnitine and CoA and their acyl-esters and on enzyme activities in rats. Relation between hepatic carnitine concentration and carnitine acet

26 June 2018

1 reference

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Entry of acetyl-L-carnitine into biosynthetic pathways

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

PPAR alpha-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Carnitine revisited: potential use as adjunctive treatment in diabetes.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Is sudden death with vitamin C deficiency caused by lack of carnitine?

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitus

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Skeletal muscle lipid metabolism with obesity

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Aging skeletal muscle mitochondria in the rat: decreased uncoupling protein-3 content

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Role of acetyl-L-carnitine in rat brain lipogenesis: implications for polyunsaturated fatty acid biosynthesis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755692

Contribution of a high dose of L-ascorbic acid to carnitine synthesis in guinea pigs fed high-fat diets

2 September 2018

1 reference

12 December 2020

Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance

1 reference

12 December 2020

Effect of starvation on the disposition of free and peptide-linked trimethyllysine in the rat

1 reference

12 December 2020

Serum carnitine levels in children with iron-deficiency anemia with or without pica

1 reference

12 December 2020

The relationship between serum carnitine levels and the nutritional status of patients with schistosomiasis

1 reference

12 December 2020

Metabolism of carnitine in phenylacetic acid-treated rats and in patients with phenylketonuria

1 reference

12 December 2020

Impaired plasma fatty acid oxidation in extremely obese women

1 reference

12 December 2020

Effect of diet on plasma carnitine levels and urinary carnitine excretion in humans

1 reference

12 December 2020

Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria

1 reference

12 December 2020

Carnitine improves peripheral glucose disposal in non-insulin-dependent diabetic patients

1 reference

12 December 2020

Mitochondrial abnormalities in a murine model of primary carnitine deficiency. Systemic pathology and trial of replacement therapy

1 reference

12 December 2020

Entry of [(1,2-13C2)acetyl]-L-carnitine in liver tricarboxylic acid cycle and lipogenesis: a study by 13C NMR spectroscopy in conscious, freely moving rats

1 reference

12 December 2020

Inhibition of carnitine biosynthesis by valproic acid in rats--the biochemical mechanism of inhibition

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.032888

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

19553674

1 reference