Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase (Q37114760)

18 August 2017

Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase (English)

1 reference

E2 ubiquitin-conjugating protein RAD6 YGL058W

18 August 2017

1 reference

1 reference

Putative ubiquitin-protein ligase UFD4 YKL010C

1 reference

Methylated-DNA--protein-cysteine methyltransferase YDL200C

1 reference

E3 ubiquitin-protein ligase UBR1 YGR184C

1 reference

author name string

Cheol-Sang Hwang

series ordinal

1

1 reference

PMC publication ID

2650122

18 August 2017

Anna Shemorry

series ordinal

2

1 reference

PMC publication ID

2650122

18 August 2017

Alexander Varshavsky

series ordinal

3

1 reference

PMC publication ID

2650122

18 August 2017

language of work or name

English

0 references

publication date

21 January 2009

1 reference

Proceedings of the National Academy of Sciences of the United States of America

18 August 2017

1 reference

18 August 2017

106

1 reference

18 August 2017

7

1 reference

18 August 2017

2142-2147

1 reference

Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Discovery of cellular regulation by protein degradation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The N-end rule pathway is a sensor of heme

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The DNA damage response: ten years after

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

HECT E3s and human disease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The mammalian N-end rule pathway: new insights into its components and physiological roles

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Repair of alkylated DNA: recent advances

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The RAD6 pathway: control of DNA damage bypass and mutagenesis by ubiquitin and SUMO.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Rpn4 is a physiological substrate of the Ubr2 ubiquitin ligase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Physical association of ubiquitin ligases and the 26S proteasome

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The E2-E3 interaction in the N-end rule pathway: the RING-H2 finger of E3 is required for the synthesis of multiubiquitin chain

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The N-end rule: functions, mysteries, uses

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

A proteolytic pathway that recognizes ubiquitin as a degradation signal

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

In vivo half-life of a protein is a function of its amino-terminal residue

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Identification and preliminary characterization of an O6-methylguanine DNA repair methyltransferase in the yeast Saccharomyces cerevisiae.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

TheSaccharomyces cerevisiae MGT1DNA repair methyltransferease gene: its promoter and entire coding sequence, regulation andin vivobiological functions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Ubiquitin as a degradation signal

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

cis-trans recognition and subunit-specific degradation of short-lived proteins

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The armadillo repeats of the Ufd4 ubiquitin ligase recognize ubiquitin-fusion proteins.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

A synthetic defect in protein degradation caused by loss of Ufd4 and Rad23.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650122

'Spalog' and 'sequelog': neutral terms for spatial and sequence similarity

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19164530

12 December 2020

inferred from PubMed ID database lookup

Expression of yeast O6-methylguanine-DNA methyltransferase (MGMT) gene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19164530

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0812316106

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hrd45lue6vdarm4we54szyonui

30 July 2022

release_hrd45lue6vdarm4we54szyonui

ADS bibcode

2009PNAS..106.2142H

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hrd45lue6vdarm4we54szyonui

30 July 2022

https://api.fatcat.wiki/v0/release/hrd45lue6vdarm4we54szyonui

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/hrd45lue6vdarm4we54szyonui

PubMed publication ID

1 reference

30 July 2022