A structural understanding of the dynamic ribosome machine (Q37091739)

18 August 2017

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title

A structural understanding of the dynamic ribosome machine (English)

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18 August 2017

Thomas A Steitz

1

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18 August 2017

publication date

1 March 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

published in

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18 August 2017

volume

9

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18 August 2017

issue

3

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18 August 2017

page(s)

242-253

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A small particulate component of the cytoplasm

18 August 2017

cites work

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Ribosome structure determined by electron microscopy of Escherichia coli small subunits, large subunits and monomeric ribosomes

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Structures of the bacterial ribosome at 3.5 A resolution

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Structure of the 70S ribosome complexed with mRNA and tRNA

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Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

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The structural basis of ribosome activity in peptide bond synthesis

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An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA.

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Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction

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Ribosomes and translation

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Selection of tRNA by the ribosome requires a transition from an open to a closed form

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Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process

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The Structural Basis of Large Ribosomal Subunit Function

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Structural insights into peptide bond formation

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The ribosomal peptidyl transferase

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Conformational switch in the decoding region of 16S rRNA during aminoacyl-tRNA selection on the ribosome.

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Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

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The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release

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Mononucleotide derivatives as ribosomal P-site substrates reveal an important contribution of the 2'-OH to activity

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Substrate-assisted catalysis of peptide bond formation by the ribosome

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Intermediate states in the movement of transfer RNA in the ribosome

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Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies

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Locking and unlocking of ribosomal motions

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The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution

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Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

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A ratchet-like inter-subunit reorganization of the ribosome during translocation

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Structural basis for interaction of the ribosome with the switch regions of GTP-bound elongation factors

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In vitro crystallization of ribosomes from chick embryos

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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

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The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

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The Geometry of the Ribosomal Polypeptide Exit Tunnel

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Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon

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A tripeptide 'anticodon' deciphers stop codons in messenger RNA.

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Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

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Crystal structure of the ribosome recycling factor bound to the ribosome

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X-ray structure of a protein-conducting channel

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Structure of the E. coli protein-conducting channel bound to a translating ribosome

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Gene-specific regulation by general translation factors

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Eukaryotic translation initiation factors and regulators

31 March 2020

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Cross-crystal averaging reveals that the structure of the peptidyl-transferase center is the same in the 70S ribosome and the 50S subunit

31 March 2020

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The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity

31 March 2020

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Ribosome structure and the mechanism of translation

31 March 2020

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Ribosome recycling factor (ribosome releasing factor) is essential for bacterial growth

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2352

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18 August 2017

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