The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation (Q37086476)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27313208%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation (English)

1 reference

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Theresia Dunzendorfer-Matt

14 March 2020

author

1

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14 March 2020

author name string

Ellen L Mercado

2

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14 March 2020

Karl Maly

3

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14 March 2020

Frank McCormick

4

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14 March 2020

Klaus Scheffzek

5

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14 March 2020

language of work or name

English

0 references

publication date

16 June 2016

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27313208%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

14 March 2020

published in

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14 March 2020

volume

113

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14 March 2020

issue

27

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14 March 2020

page(s)

7497-7502

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A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor

14 March 2020

cites work

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29 September 2017

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29 September 2017

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Solubility survey of fragments of the neurofibromatosis type 1 protein neurofibromin

29 September 2017

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Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations

29 September 2017

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29 September 2017

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The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

29 September 2017

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29 September 2017

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Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype

29 September 2017

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Getting a first clue about SPRED functions

29 September 2017

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29 September 2017

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29 September 2017

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Modulation of signalling by Sprouty: a developing story

29 September 2017

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EVH1 domains: structure, function and interactions

29 September 2017

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Identification of a dominant negative mutant of Sprouty that potentiates fibroblast growth factor- but not epidermal growth factor-induced ERK activation

29 September 2017

1 reference

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Spred is a Sprouty-related suppressor of Ras signalling

29 September 2017

1 reference

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NF1 tumor suppressor gene function: narrowing the GAP

29 September 2017

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Neurofibromin, a tumor suppressor in the nervous system

29 September 2017

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Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain

29 September 2017

1 reference

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Guanosine triphosphatase stimulation of oncogenic Ras mutants

29 September 2017

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Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly

29 September 2017

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Structural analysis of the GAP-related domain from neurofibromin and its implications

29 September 2017

1 reference

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Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras

29 September 2017

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The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

29 September 2017

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29 September 2017

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Ras-regulated signaling processes in Saccharomyces cerevisiae

29 September 2017

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SPRED proteins provide a NF-ty link to Ras suppression

29 September 2017

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A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1.

27 June 2018

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27 June 2018

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C-terminal truncation of p21H preserves crucial kinetic and structural properties.

27 June 2018

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27 June 2018

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The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

27 June 2018

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SPRED1, a RAS MAPK pathway inhibitor that causes Legius syndrome, is a tumour suppressor downregulated in paediatric acute myeloblastic leukaemia

27 June 2018

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Neurofibromatosis-1 gene deletions and mutations in de novo adult acute myeloid leukemia

3 September 2018

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A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein.

3 September 2018

1 reference

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FGF signal interpretation is directed by Sprouty and Spred proteins during mesoderm formation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941445

1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941445

A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4941445

Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1607298113

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

21 January 2018

1 reference

12 December 2020

Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAP and neurofibromin

1 reference

12 December 2020

Individual Rate Constants for the Interaction of Ras Proteins with GTPase-Activating Proteins Determined by Fluorescence Spectroscopy

1 reference

12 December 2020

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1607298113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27313208%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27313208%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

27313208

1 reference