Mitochondrial complex III regulates hypoxic activation of HIF. (Q37064874)

18 August 2017

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title

Mitochondrial complex III regulates hypoxic activation of HIF. (English)

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18 August 2017

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T Klimova

1

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18 August 2017

N S Chandel

series ordinal

2

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18 August 2017

publication date

25 January 2008

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Cell Death & Differentiation

18 August 2017

published in

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18 August 2017

volume

15

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18 August 2017

issue

4

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18 August 2017

page(s)

660-666

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Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Redox regulation of p53 during hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Purification and characterization of hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Perspectives on oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Mitochondrial formation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Mitochondrial regulation of oxygen sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Complex III releases superoxide to both sides of the inner mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

HIF-dependent antitumorigenic effect of antioxidants in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

Intracellular diffusion gradients of O2 and ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402307

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402307

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Dimensions Publication ID

18 August 2017

1037230255

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