Ral GTPases and cancer: linchpin support of the tumorigenic platform (Q37064855)

18 August 2017

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title

Ral GTPases and cancer: linchpin support of the tumorigenic platform (English)

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18 August 2017

Brian O Bodemann

1

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18 August 2017

Michael A White

series ordinal

2

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18 August 2017

language of work or name

English

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publication date

1 February 2008

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18 August 2017

published in

Nature Reviews Cancer

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18 August 2017

volume

8

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18 August 2017

issue

2

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18 August 2017

page(s)

133-140

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Evidence for a Ras/Ral signaling cascade

18 August 2017

cites work

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Ral-GTPases: approaching their 15 minutes of fame

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Ral GTPases: corrupting the exocyst in cancer cells

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Species- and cell type-specific requirements for cellular transformation

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Distinct requirements for Ras oncogenesis in human versus mouse cells

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Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways

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Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

31 March 2020

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Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.

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RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival

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RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

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Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

31 March 2020

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The tumor suppressor PP2A Abeta regulates the RalA GTPase

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Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers

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Alterations of the PPP2R1B gene in human lung and colon cancer

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Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms

31 March 2020

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A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region

31 March 2020

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Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening.

31 March 2020

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PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

31 March 2020

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The Hallmarks of Cancer

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Putting tumours in context

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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone

31 March 2020

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Expression profiling of Ral-depleted bladder cancer cells identifies RREB-1 as a novel transcriptional Ral effector

31 March 2020

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The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer

31 March 2020

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RalGDS is required for tumor formation in a model of skin carcinogenesis.

31 March 2020

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Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

31 March 2020

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Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

31 March 2020

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RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity

31 March 2020

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The exocyst is a Ral effector complex

31 March 2020

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The exocyst complex binds the small GTPase RalA to mediate filopodia formation

31 March 2020

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Ral GTPases regulate exocyst assembly through dual subunit interactions

31 March 2020

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Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors

31 March 2020

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Regression of melanoma in a murine model by RLIP76 depletion

31 March 2020

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Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1)

31 March 2020

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mTOR-independent translational control of the extrinsic cell death pathway by RalA.

31 March 2020

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Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway

31 March 2020

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Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB.

31 March 2020

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

31 March 2020

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NF-kappaB signals induce the expression of c-FLIP.

31 March 2020

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The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression

31 March 2020

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Functional interaction between the ZO-1-interacting transcription factor ZONAB/DbpA and the RNA processing factor symplekin

31 March 2020

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The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density

31 March 2020

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Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA

31 March 2020

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Protein complexes in transport vesicle targeting

31 March 2020

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The exocyst complex in polarized exocytosis

31 March 2020

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The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin

31 March 2020

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RalB mobilizes the exocyst to drive cell migration

31 March 2020

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RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis

31 March 2020

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Inferences, questions and possibilities in Toll-like receptor signalling

31 March 2020

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Another detour on the Toll road to the interferon antiviral response

31 March 2020

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Connecting mitochondria and innate immunity

31 March 2020

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Double-stranded RNA-mediated TLR3 activation is enhanced by CD14.

31 March 2020

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

31 March 2020

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Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

31 March 2020

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

31 March 2020

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Triggering the interferon antiviral response through an IKK-related pathway

31 March 2020

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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

31 March 2020

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Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding [...]

31 March 2020

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Regulation and function of IKK and IKK-related kinases

31 March 2020

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Integrative genomic approaches identify IKBKE as a breast cancer oncogene

31 March 2020

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RalB signaling: a bridge between inflammation and cancer

31 March 2020

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Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway

31 March 2020

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Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer

31 March 2020

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Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs

31 March 2020

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IKK-i/IKKepsilon controls constitutive, cancer cell-associated NF-kappaB activity via regulation of Ser-536 p65/RelA phosphorylation

31 March 2020

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SIGNAL TRANSDUCTION: Prelude to an Anniversary for the RAS Oncogene

31 March 2020

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Expression of ral GTPases, their effectors, and activators in human bladder cancer

31 March 2020

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Human rgr: transforming activity and alteration in T-cell malignancies

31 March 2020

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The Rgr oncogene induces tumorigenesis in transgenic mice

31 March 2020

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PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism

31 March 2020

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Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation

31 March 2020

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Functional analysis of RalGPS2, a murine guanine nucleotide exchange factor for RalA GTPase

31 March 2020

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Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome

31 March 2020

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The consensus coding sequences of human breast and colorectal cancers

31 March 2020

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The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

31 March 2020

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Patterns of somatic mutation in human cancer genomes

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2296

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18 August 2017

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