New concepts in the mechanism of ammonia-induced astrocyte swelling (Q36933320)

17 August 2017

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title

New concepts in the mechanism of ammonia-induced astrocyte swelling (English)

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17 August 2017

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Norenberg MD

1

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17 August 2017

Jayakumar AR

series ordinal

2

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17 August 2017

Rama Rao KV

series ordinal

3

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17 August 2017

Panickar KS

series ordinal

4

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17 August 2017

publication date

1 December 2007

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17 August 2017

published in

Metabolic Brain Disease

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17 August 2017

volume

22

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17 August 2017

issue

3-4

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17 August 2017

page(s)

219-234

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Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy

17 August 2017

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Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia

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12 December 2020

Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis

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12 December 2020

Oxidative stress in the pathogenesis of hepatic encephalopathy

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12 December 2020

Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow

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Electron microscopic study of brain capillaries in cerebral edema from fulminant hepatic failure

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12 December 2020

Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model.

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Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade

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Phagocytes and oxidative stress

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Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema

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Role of nitric oxide in inflammation

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Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.

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Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia

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The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

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Liver derived pro-inflammatory cytokines may be important in producing intracranial hypertension in acute liver failure

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12 December 2020

Effect of ascorbic acid on hyperoxic rat astrocytes

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12 December 2020

Protein kinase cascades activated by stress and inflammatory cytokines

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12 December 2020

Cerebral vasomotor paralysis produced by ammonia intoxication

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12 December 2020

Mechanisms of ammonia-induced astrocyte swelling

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12 December 2020

Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.

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12 December 2020

The effect of indomethacin on intracranial pressure, cerebral perfusion and extracellular lactate and glutamate concentrations in patients with fulminant hepatic failure

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12 December 2020

Cerebral metabolic and histological effects of thioacetamide-induced liver failure

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12 December 2020

Hyperammonemic encephalopathy

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12 December 2020

Ammonia-induced swelling of rat cerebral cortical slices: implications for the pathogenesis of brain edema in acute hepatic failure

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12 December 2020

Suppression of ammonia-induced swelling by aspartate but not by ornithine in primary cultures of rat astrocytes

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12 December 2020

Ammonia-induced production of free radicals in primary cultures of rat astrocytes

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12 December 2020

Hepatic encephalopathy and cerebral edema

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The roles of dopamine oxidative stress and dopamine receptor signaling in aging and age-related neurodegeneration.

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12 December 2020

Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation

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12 December 2020

Role of oxidative stress in the ammonia-induced mitochondrial permeability transition in cultured astrocytes

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12 December 2020

Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study

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12 December 2020

Correlation between ammonia levels and the severity of hepatic encephalopathy

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12 December 2020

Swelling-activated release of excitatory amino acids in the brain: relevance for pathophysiology

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12 December 2020

Ammonia-induced heme oxygenase-1 expression in cultured rat astrocytes and rat brain in vivo

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12 December 2020

Phospholipid degradation and cellular edema induced by free radicals in brain cortical slices

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12 December 2020

Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

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12 December 2020

Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis

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12 December 2020

Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats

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12 December 2020

The pathophysiology of brain edema in acute liver failure

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12 December 2020

Fulminant hepatic failure: summary of a workshop

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12 December 2020

Oxidants as stimulators of signal transduction

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12 December 2020

Alterations to glutathione and nicotinamide nucleotides during the mitochondrial permeability transition induced by peroxynitrite

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12 December 2020

Glutamine: a Trojan horse in ammonia neurotoxicity

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12 December 2020

The role of arachidonic acid and oxygen radical metabolites in the pathogenesis of vasogenic brain edema and astrocytic swelling

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12 December 2020

Increased brain uptake of gamma-aminobutyric acid in a rabbit model of hepatic encephalopathy.

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12 December 2020

Hepatic encephalopathy

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12 December 2020

Fine structural localization of glutamine synthetase in astrocytes of rat brain

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12 December 2020

Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

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12 December 2020

Cerebrospinal fluid glutamine as a measure of hepatic encephalopathy

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12 December 2020

Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling

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12 December 2020

Acute hyperammonemia in the young primate: physiologic and neuropathologic correlates

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12 December 2020

The mitochondrial permeability transition

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12 December 2020

Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis

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12 December 2020

Mitochondrial permeability transitions: how many doors to the house?

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12 December 2020

Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats

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12 December 2020

Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling

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12 December 2020

Ascorbate inhibits edema in brain slices

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12 December 2020

Induction of the mitochondrial permeability transition in cultured astrocytes by glutamine

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12 December 2020

Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat

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12 December 2020

A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture

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12 December 2020

Determination of carbonyl content in oxidatively modified proteins

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12 December 2020

Control of cerebral oedema by total hepatectomy and extracorporeal liver support in fulminant hepatic failure

1 reference

12 December 2020

Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study

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12 December 2020

Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes.

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12 December 2020

Ammonia-induced astrocyte swelling in primary culture

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12 December 2020

Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current.

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12 December 2020

Correlations between energy metabolism, ion transport, and water content in astrocytes

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12 December 2020

Elevation of glutathione levels by ammonium ions in primary cultures of rat astrocytes

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12 December 2020

Electron microscopy in human hepatic encephalopathy

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12 December 2020

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

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12 December 2020

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats

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12 December 2020

The mitochondrial death/life regulator in apoptosis and necrosis

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12 December 2020

Plasma and Brain Amino Acids in Fulminant Hepatic Failure and their Relationship to Hepatic Encephalopathy

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12 December 2020

Amino acid changes in regions of the CNS in relation to function in experimental portal-systemic encephalopathy

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12 December 2020

Factors associated with severe intracranial hypertension in candidates for emergency liver transplantation

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12 December 2020

The brain in experimental portal-systemic encephalopathy. II. Water and electrolyte changes

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12 December 2020

MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive ox

1 reference

12 December 2020

Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes

1 reference

12 December 2020

Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis

1 reference

12 December 2020

Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes

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12 December 2020

Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes

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12 December 2020

The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation

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12 December 2020

Total hepatectomy and liver transplantation as two-stage procedure

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12 December 2020

Brain edema and the blood brain barrier in galactosamine-induced fulminant hepatic failure rats. An animal model for evaluation of liver support systems.

1 reference

12 December 2020

Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure

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12 December 2020

Cerebral amino acid levels and uptake in rats after portocaval anastomosis: II. Regional studies in vivo

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12 December 2020

Fulminant hepatic failure induced oxidative stress in nonsynaptic mitochondria of cerebral cortex in rats

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12 December 2020

Ammonia selectively stimulates neutral amino acid transport across blood-brain barrier

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12 December 2020

Partial pressure of ammonia versus ammonia in hepatic encephalopathy.

1 reference

12 December 2020

A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy. Progression and reversal of the disorder

1 reference

12 December 2020

Astrocyte swelling in liver failure: role of glutamine and benzodiazepines

1 reference

12 December 2020

Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

1 reference

12 December 2020

Cortical astrocytes exposed to tributyltin undergo morphological changes in vitro.

1 reference

12 December 2020

Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver.

1 reference

12 December 2020

Brain ion and amino acid contents during edema development in hepatic encephalopathy

1 reference

12 December 2020

Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration

1 reference

12 December 2020

Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy

1 reference

12 December 2020

Suppression of ammonia-induced astrocyte swelling by cyclosporin A.

1 reference

12 December 2020

Cerebral edema and intracranial hypertension in acute liver failure: Distinct aspects of the same problem

1 reference

12 December 2020

Microsomal lipid peroxidation

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12 December 2020

Increased aquaporin-4 expression in ammonia-treated cultured astrocytes

1 reference

12 December 2020

Hepatic encephalopathy and brain edema in acute hepatic failure: does glutamate play a role?

1 reference

12 December 2020

Mitochondrial implication in accidental and programmed cell death: apoptosis and necrosis

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12 December 2020

Oxidative stress in Ca(2+)-induced membrane permeability transition in brain mitochondria

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12 December 2020

The systemic inflammatory response syndrome in acute liver failure

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12 December 2020

Superoxide production and antioxidant enzymes in ammonia intoxication in rats.

1 reference

12 December 2020

Permeabilization of the inner mitochondrial membrane by Ca2+ ions is stimulated by t-butyl hydroperoxide and mediated by reactive oxygen species generated by mitochondria

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12 December 2020

Proton spectroscopy of brain glutamine in acute liver failure

1 reference

12 December 2020

Antioxidant and redox regulation of gene transcription

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12 December 2020

Regional cerebral edema and chloride space in galactosamine-induced liver failure in rats.

1 reference

12 December 2020

Etiology and outcome for 295 patients with acute liver failure in the United States.

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12 December 2020

GeneChip analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats

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12 December 2020

CI-1010 induced opening of the mitochondrial permeability transition pore precedes oxidative stress and apoptosis in SY5Y neuroblastoma cells

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12 December 2020

Current concepts of brain edema. Review of laboratory investigations

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12 December 2020

Cerebral cortex ammonia and glutamine metabolism in two rat models of chronic liver insufficiency-induced hyperammonemia: influence of pair-feeding

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12 December 2020

Liver transplantation in Europe for patients with acute liver failure.

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12 December 2020

Astrocyte metabolism of [15N]glutamine: implications for the glutamine-glutamate cycle

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12 December 2020

Oxidative and nitrosative stress in ammonia neurotoxicity

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12 December 2020

Changes in the blood-brain barrier in hepatic coma after hepatectomy in the rat

1 reference

12 December 2020

Beta-oxidation of [1-14C]palmitic acid by mouse astrocytes in primary culture: effects of agents implicated in the encephalopathy of Reye's syndrome

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12 December 2020

Aspartate aminotransferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and nonsynaptic mitochondria: effects of in vitro treatment with ammonia, hyperammonemia and hepatic encephalopathy

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12 December 2020

Amino acid, ammonia and neurotransmitter concentrations in hepatic encephalopathy: serial analysis in plasma and cerebrospinal fluid during treatment with an adapted amino acid solution

1 reference

12 December 2020

Oxidative stress and c-Jun-amino-terminal kinase activation involved in apoptosis of primary astrocytes induced by disulfiram-Cu(2+) complex

1 reference

12 December 2020

Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase

1 reference

12 December 2020

Swelling of glial cells in lactacidosis and by glutamate: significance of Cl—-transport

1 reference

12 December 2020

Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy

1 reference

12 December 2020

Effects of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy

1 reference

12 December 2020

1 reference

12 December 2020

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 reference

12 December 2020

Cerebrospinal fluid lactate in patients with hepatic encephalopathy

1 reference

12 December 2020

Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord

1 reference

12 December 2020

The inflammatory basis of intracranial hypertension in acute liver failure

1 reference

12 December 2020

Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia

1 reference

12 December 2020

Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts

1 reference

12 December 2020

Ammonia neurotoxicity: role of the mitochondrial permeability transition

1 reference

12 December 2020

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

1 reference

12 December 2020

Cerebral Edema: A Major Complication of Massive Hepatic Necrosis

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12 December 2020

Effects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria

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12 December 2020

Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis

1 reference

12 December 2020

Pharmacological inhibitors of MAPK pathways.

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12 December 2020

Differential response of glutamine in cultured neurons and astrocytes

1 reference

12 December 2020

Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier

1 reference

12 December 2020

Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors

1 reference

12 December 2020

Fulminant hepatic failure. Clinical features, etiology, epidemiology, and current management

1 reference

12 December 2020

Activities of pyruvate dehydrogenase, enzymes of citric acid cycle, and aminotransferases in the subcellular fractions of cerebral cortex in normal and hyperammonemic rats.

1 reference

12 December 2020

Glutamine-induced free radical production in cultured astrocytes

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12 December 2020

Brain edema and hepatic encephalopathy

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12 December 2020

Cytotoxic edema is responsible for raised intracranial pressure in fulminant hepatic failure: in vivo demonstration using diffusion-weighted MRI in human subjects

1 reference

12 December 2020

Increased blood-brain transfer in a rabbit model of acute liver failure

1 reference

12 December 2020

Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy.

1 reference

12 December 2020

10.1007/S11011-007-9062-5

Identifiers

DOI

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17 August 2017

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