The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis (Q36831216)

16 August 2017

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title

The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesis (English)

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16 August 2017

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Suzie Ariyaratana

1

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16 August 2017

David M Loeb

series ordinal

2

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16 August 2017

language of work or name

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24 May 2007

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Expert Reviews in Molecular Medicine

16 August 2017

published in

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16 August 2017

volume

9

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16 August 2017

issue

14

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16 August 2017

page(s)

1-17

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The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation

16 August 2017

cites work

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Clinical significance of minimal residual disease in childhood acute myeloid leukemia

21 January 2018

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Functional characterization of WT1 binding sites within the human vitamin D receptor gene promoter

21 January 2018

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Regulation of insulin-like growth factor I receptor gene expression by the Wilms' tumor suppressor WT1.

21 January 2018

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The transcriptional effect of WT1 is modulated by choice of expression vector

21 January 2018

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7 January 2021

Regulation of gene expression by WT1 in development and tumorigenesis

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7 January 2021

The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites

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https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Regulation of ornithine decarboxylase gene expression by the Wilms' tumor suppressor WT1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 induces apoptosis through transcriptional regulation of the proapoptotic Bcl-2 family member Bak.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 proteins: functions in growth and differentiation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Regulation of taurine transporter gene (TauT) by WT1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms tumor suppressor-1 target gene podocalyxin is transcriptionally repressed by p53.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

E-cadherin is a WT1 target gene

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Repression of the c-myb gene by WT1 protein in T and B cell lines

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms' tumor gene product (WT1) modulates the response to 1,25-dihydroxyvitamin D3 by induction of the vitamin D receptor

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

A review of the Wilms' tumor 1 gene (WT1) and its role in hematopoiesis and leukemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Identification of connective tissue growth factor as a target of WT1 transcriptional regulation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Regulation of insulin-like growth factor I receptor promoter activity by wild-type and mutant versions of the WT1 tumor suppressor

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The antiapoptotic gene A1/BFL1 is a WT1 target gene that mediates granulocytic differentiation and resistance to chemotherapy

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Development of WT1 peptide cancer vaccine against hematopoietic malignancies and solid cancers

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 peptide vaccination combined with BCG-CWS is more efficient for tumor eradication than WT1 peptide vaccination alone

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

AML1-ETO rapidly induces acute myeloblastic leukemia in cooperation with the Wilms tumor gene, WT1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Presence of WT1, the Wilm's tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 gene expression: an excellent tool for monitoring minimal residual disease in 70% of acute myeloid leukaemia patients - results from a single-centre study

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Truncated WT1 mutants alter the subnuclear localization of the wild-type protein

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Analysis of WT1 target gene expression in stably transfected cell lines

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Use of reverse transcriptase polymerase chain reaction for diagnosis and staging of alveolar rhabdomyosarcoma, Ewing sarcoma family of tumors, and desmoplastic small round cell tumor

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Differential Effects of Wilms Tumor WT1 Splice Variants on the Insulin Receptor Promoter

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Expression of WT1 in Pediatric Small Cell Tumors: Report of Two Cases with a Possible Mesothelial Origin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Cyclin E is a target of WT1 transcriptional repression

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Second malignant neoplasms following treatment for Wilm's tumor: a report from the National Wilms' Tumor Study Group

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Complete remission in a patient with recurrent acute myeloid leukemia induced by vaccination with WT1 peptide in the absence of hematological or renal toxicity

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Cytotoxic T-lymphocyte responses elicited to Wilms' tumor gene WT1 product by DNA vaccination

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Transcriptional repression mediated by the WT1 Wilms tumor gene product

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms tumour (WT1) gene is mutated in a secondary leukaemia in a WAGR patient

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT-1 is required for early kidney development

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Secondary acute myelogenous leukemia in patients previously treated for childhood renal tumors: a report from the National Wilms Tumor Study Group

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Very low frequencies of human normal CD34+ haematopoietic progenitor cells express the Wilms' tumour gene WT1 at levels similar to those in leukaemia cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Role of Wilms tumor 1 (WT1) in the transcriptional regulation of the Mullerian-inhibiting substance promoter

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Alternative splicing and genomic structure of the Wilms tumor gene WT1

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Transcriptional activation of c-myc proto-oncogene by WT1 protein

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

LLC-PK1 cell growth is repressed by WT1 inhibition of G-protein alpha i-2 protooncogene transcription

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

RNA binding by the Wilms tumor suppressor zinc finger proteins.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 as a universal marker for minimal residual disease detection and quantification in myeloid leukemias and in myelodysplastic syndrome.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms tumor suppressor Wt1 promotes cell adhesion through transcriptional activation of the alpha4integrin gene

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Prognostic significance of WT1 gene expression at diagnosis in adult de novo acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 is a tumor-associated antigen in colon cancer that can be recognized by in vitro stimulated cytotoxic T cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Role of the WT1 tumor suppressor in murine hematopoiesis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Ornithine decarboxylase is a transcriptional target of tumor suppressor WT1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Expression of Wilms' tumor gene 1 at different stages of acute myeloid leukemia and analysis of its major splice variants.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1 gene transcript assay for relapse in acute leukemia after transplantation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Direct recognition and lysis of leukemia cells by WT1-specific CD4+ T lymphocytes in an HLA class II-restricted manner

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Overexpression of the Wilms' tumor gene WT1 in head and neck squamous cell carcinoma.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Transcriptional repression of human insulin-like growth factor-II P4 promoter by Wilms' tumor suppressor WT1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms tumor suppressor gene WT1 induces G1 arrest and apoptosis in myeloblastic leukemia M1 cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Multiplex real-time RT-PCR for prospective evaluation of WT1 and fusion gene transcripts in newly diagnosed de novo acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Wilms' tumour gene (wt1) expression at diagnosis has no prognostic relevance in childhood acute lymphoblastic leukaemia treated by an intensive chemotherapy protocol

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The Wilms' tumor gene product represses the transcription of thrombospondin 1 in response to overexpression of c-Jun

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Fluorescent 5'-exonuclease assay for the absolute quantification of Wilms' tumour gene (WT1) mRNA: implications for monitoring human leukaemias

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Monitoring minimal residual disease in leukemia using real-time quantitative polymerase chain reaction for Wilms tumor gene (WT1).

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

The human sex-determining gene SRY is a direct target of WT1.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

A non-AUG translational initiation event generates novel WT1 isoforms

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

High WT1 expression after induction therapy predicts high risk of relapse and death in pediatric acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Successful rapid discontinuation of immunosuppressive therapy at molecular relapse after allogeneic bone marrow transplantation in a pediatric patient with myelodysplastic syndrome

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Cancer immunotherapy targeting Wilms' tumor gene WT1 product

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

Phase I/II study of vaccination with dendritic-like leukaemia cells for the immunotherapy of acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000336

7 January 2021

10.1017/S1462399407000336

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