The epigenetic regulation of mammalian telomeres (Q36761196)

16 August 2017

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title

The epigenetic regulation of mammalian telomeres (English)

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16 August 2017

María A Blasco

1

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publication date

1 April 2007

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16 August 2017

published in

Nature Reviews Genetics

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16 August 2017

volume

8

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16 August 2017

issue

4

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16 August 2017

page(s)

299-309

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Shelterin: the protein complex that shapes and safeguards human telomeres

16 August 2017

cites work

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New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin

31 March 2020

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Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

31 March 2020

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Telomerase in the human organism

31 March 2020

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The first molecular details of ALT in human tumor cells

31 March 2020

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Telomere maintenance by recombination in human cells.

31 March 2020

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Telomere length regulation in mice is linked to a novel chromosome locus.

31 March 2020

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Effects of telomerase and telomere length on epidermal stem cell behavior

31 March 2020

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

31 March 2020

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Essential role of mouse telomerase in highly proliferative organs

31 March 2020

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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

31 March 2020

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Dyskeratosis congenita -- a disease of dysfunctional telomere maintenance

31 March 2020

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Telomerase therapeutics for cancer: challenges and new directions

31 March 2020

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Telomere position effect in human cells

31 March 2020

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Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity

31 March 2020

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Nucleosomal organization of telomere-specific chromatin in rat

31 March 2020

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Unusual chromatin in human telomeres

31 March 2020

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Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

31 March 2020

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Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

31 March 2020

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DNA methyltransferases control telomere length and telomere recombination in mammalian cells

31 March 2020

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

31 March 2020

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Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy

31 March 2020

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A role for the Rb family of proteins in controlling telomere length

31 March 2020

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Telomeres and human disease: ageing, cancer and beyond

31 March 2020

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Mammalian telomeres end in a large duplex loop

31 March 2020

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T-loops and the origin of telomeres

31 March 2020

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RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability

31 March 2020

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Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance

31 March 2020

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Transcriptional silencing at Saccharomyces telomeres: implications for other organisms

31 March 2020

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A protein-counting mechanism for telomere length regulation in yeast.

31 March 2020

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C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae

31 March 2020

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Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats.

31 March 2020

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Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length

31 March 2020

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SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres

31 March 2020

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Regulation of telomere length and function by a Myb-domain protein in fission yeast

31 March 2020

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Pot1, the putative telomere end-binding protein in fission yeast and humans

31 March 2020

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spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast

31 March 2020

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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

31 March 2020

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PTOP interacts with POT1 and regulates its localization to telomeres

31 March 2020

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Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

31 March 2020

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

31 March 2020

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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres

31 March 2020

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

31 March 2020

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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

31 March 2020

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Telomere maintenance requires the RAD51D recombination/repair protein

31 March 2020

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The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response

31 March 2020

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Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

31 March 2020

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Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis

31 March 2020

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XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

31 March 2020

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Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia

31 March 2020

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Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

31 March 2020

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Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication

31 March 2020

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Conditional telomerase induction causes proliferation of hair follicle stem cells

31 March 2020

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The unusual telomeres of Drosophila.

31 March 2020

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An alternative pathway for yeast telomere maintenance rescues est1- senescence

31 March 2020

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Telomere maintenance without telomerase

31 March 2020

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Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae

31 March 2020

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Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

31 March 2020

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Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

31 March 2020

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Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA

31 March 2020

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Impaired germinal center reaction in mice with short telomeres.

31 March 2020

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Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

31 March 2020

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Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres

31 March 2020

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Effects of genomic position on the expression of transduced copies of the white gene of Drosophila.

31 March 2020

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Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

31 March 2020

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RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.

31 March 2020

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Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

31 March 2020

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Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

31 March 2020

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Multiple interactions in Sir protein recruitment by Rap1p at silencers and telomeres in yeast.

31 March 2020

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Saccharomyces telomeres assume a non-nucleosomal chromatin structure

31 March 2020

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Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast

31 March 2020

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SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast

31 March 2020

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Telomere folding is required for the stable maintenance of telomere position effects in yeast

31 March 2020

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Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression

31 March 2020

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Cohabitation of insulators and silencing elements in yeast subtelomeric regions

31 March 2020

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Limitations of silencing at native yeast telomeres

31 March 2020

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Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.

31 March 2020

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UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior

31 March 2020

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TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

31 March 2020

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The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae

31 March 2020

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SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes

31 March 2020

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Sir-mediated repression can occur independently of chromosomal and subnuclear contexts

31 March 2020

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Subtelomeric proteins negatively regulate telomere elongation in budding yeast

31 March 2020

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Subtelomeric factors antagonize telomere anchoring and Tel1-independent telomere length regulation

31 March 2020

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Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process

31 March 2020

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Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

31 March 2020

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Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

31 March 2020

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Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres

31 March 2020

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Fission yeast Arp6 is required for telomere silencing, but functions independently of Swi6

31 March 2020

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RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast

31 March 2020

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HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila.

31 March 2020

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Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline

31 March 2020

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Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.

31 March 2020

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Role of SUMO in the dynamics of telomere maintenance in fission yeast

31 March 2020

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The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway

31 March 2020

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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

31 March 2020

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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

31 March 2020

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Heterochromatin and tri-methylated lysine 20 of histone H4 in animals

31 March 2020

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

31 March 2020

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Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres

31 March 2020

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SALL1, the gene mutated in Townes-Brocks syndrome, encodes a transcriptional repressor which interacts with TRF1/PIN2 and localizes to pericentromeric heterochromatin

31 March 2020

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Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2

31 March 2020

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The fundamental role of epigenetic events in cancer

31 March 2020

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Enhanced gene targeting frequency in ES cells with low genomic methylation levels

31 March 2020

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Suppression of crossing-over by DNA methylation in Ascobolus

31 March 2020

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Cytosine methylation of repeated sequences in eukaryotes: the role of DNA pairing

31 March 2020

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Telomere position effect and silencing of transgenes near telomeres in the mouse.

31 March 2020

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Modification of subtelomeric DNA

31 March 2020

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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

31 March 2020

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Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

31 March 2020

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The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin

31 March 2020

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Position effect of human telomeric repeats on replication timing

31 March 2020

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Testing the position-effect variegation hypothesis for facioscapulohumeral muscular dystrophy by analysis of histone modification and gene expression in subtelomeric 4q

31 March 2020

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Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing

31 March 2020

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Normal human telomeres are not late replicating

31 March 2020

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Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

31 March 2020

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POT1 as a terminal transducer of TRF1 telomere length control

31 March 2020

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Homologous recombination generates T-loop-sized deletions at human telomeres

31 March 2020

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Resolution of sister telomere association is required for progression through mitosis

31 March 2020

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Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast

31 March 2020

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Progressive cis-inhibition of telomerase upon telomere elongation.

31 March 2020

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Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.

31 March 2020

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Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

31 March 2020

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The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

31 March 2020

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Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

31 March 2020

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

31 March 2020

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Association between telomere length in blood and mortality in people aged 60 years or older

31 March 2020

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Obesity, cigarette smoking, and telomere length in women

31 March 2020

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Accelerated telomere shortening in response to life stress

31 March 2020

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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

31 March 2020

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

31 March 2020

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Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

31 March 2020

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PIASy-deficient mice display modest defects in IFN and Wnt signaling

31 March 2020

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The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice

31 March 2020

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A novel telomere structure in a human alternative lengthening of telomeres cell line

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG2047

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16 August 2017

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