New antibiotics from bacterial natural products (Q36679241)

15 August 2017

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title

New antibiotics from bacterial natural products (English)

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15 August 2017

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1

Jon Clardy

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15 August 2017

2

Michael A Fischbach

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15 August 2017

3

Christopher T Walsh

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15 August 2017

language of work or name

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1 December 2006

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15 August 2017

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15 August 2017

volume

24

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15 August 2017

issue

12

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15 August 2017

page(s)

1541-1550

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Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity

15 August 2017

cites work

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The Nobel chronicles. 1988: James Whyte Black, (b 1924), Gertrude Elion (1918-99), and George H Hitchings (1905-98).

21 January 2018

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7 January 2021

Antibacterial natural products in medicinal chemistry--exodus or revival?

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7 January 2021

How many antibiotics are produced by the genus Streptomyces?

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7 January 2021

Marcel Faber Roundtable: is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration?

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7 January 2021

Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites

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7 January 2021

Antibiotic-producing ability by representatives of a newly discovered lineage of actinomycetes.

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7 January 2021

A molecular view of microbial diversity and the biosphere

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7 January 2021

Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment

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7 January 2021

Laboratory cultivation of widespread and previously uncultured soil bacteria

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7 January 2021

Heterologous production of epothilone C and D in Escherichia coli.

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7 January 2021

Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

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7 January 2021

Microbial genomics for the improvement of natural product discovery

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7 January 2021

Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways.

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7 January 2021

Combinatorial biosynthesis of antibiotics: challenges and opportunities

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7 January 2021

Combinatorial biosynthesis of reduced polyketides

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7 January 2021

Pantoea agglomerans strain EH318 produces two antibiotics that inhibit Erwinia amylovora in vitro

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7 January 2021

Pantocin B, an Antibiotic fromErwinia herbicolaDiscovered by Heterologous Expression of Cloned Genes

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7 January 2021

Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes

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7 January 2021

The biosynthetic gene cluster of Pantocin a provides insights into biosynthesis and a tool for screening

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7 January 2021

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

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7 January 2021

A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid

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7 January 2021

The soil metagenome--a rich resource for the discovery of novel natural products

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7 January 2021

Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms

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7 January 2021

Novel natural products from soil DNA libraries in a streptomycete host

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7 January 2021

Long-chain N-acyltyrosine synthases from environmental DNA

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7 January 2021

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7 January 2021

Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water

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7 January 2021

Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.

1 reference

7 January 2021

Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom.

1 reference

7 January 2021

Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural products

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7 January 2021

Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA

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7 January 2021

The impact of bacterial genomics on natural product research.

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7 January 2021

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

1 reference

7 January 2021

Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster.

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7 January 2021

Drug discovery from natural products

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7 January 2021

Microbial genomics as a guide to drug discovery and structural elucidation: ECO-02301, a novel antifungal agent, as an example.

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7 January 2021

Mechanisms of EF-Tu, a pioneer GTPase

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7 January 2021

Structural Basis of the Action of Pulvomycin and GE2270 A on Elongation Factor Tu†,‡

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7 January 2021

Enacyloxin IIa pinpoints a binding pocket of elongation factor Tu for development of novel antibiotics

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7 January 2021

The structures of four macrolide antibiotics bound to the large ribosomal subunit

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7 January 2021

Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit

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7 January 2021

Improving on nature: antibiotics that target the ribosome

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7 January 2021

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

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7 January 2021

Enzymology of acyl chain macrocyclization in natural product biosynthesis

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7 January 2021

Polyketide and nonribosomal peptide antibiotics: modularity and versatility

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7 January 2021

The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae

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7 January 2021

Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry

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7 January 2021

Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics

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7 January 2021

Natural products to drugs: daptomycin and related lipopeptide antibiotics

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7 January 2021

Dysregulation of bacterial proteolytic machinery by a new class of antibiotics

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7 January 2021

Communication between ClpX and ClpP during substrate processing and degradation

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7 January 2021

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

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7 January 2021

Structure and Mechanism of DNA Topoisomerases

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7 January 2021

Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

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7 January 2021

Inhibiting bacterial fatty acid synthesis

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7 January 2021

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

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7 January 2021

Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action

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7 January 2021

Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants

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7 January 2021

Identification and characterization of the first class of potent bacterial acetyl-CoA carboxylase inhibitors with antibacterial activity

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7 January 2021

Lipid II as a target for antibiotics

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7 January 2021

Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production

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7 January 2021

Glycopeptide and lipoglycopeptide antibiotics

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7 January 2021

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

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7 January 2021

Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria

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7 January 2021

Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens

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7 January 2021

Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity

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7 January 2021

New developments in lantibiotic biosynthesis and mode of action.

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7 January 2021

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis.

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7 January 2021

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity

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7 January 2021

The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics

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7 January 2021

Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. Tü 6075. II. Structure elucidation

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7 January 2021

Arylomycins A and B, new biaryl-bridged lipopeptide antibiotics produced by Streptomyces sp. Tü 6075. I. Taxonomy, fermentation, isolation and biological activities.

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7 January 2021

Novel lipoglycopeptides as inhibitors of bacterial signal peptidase I.

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7 January 2021

Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor

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7 January 2021

Abyssomicin C-A polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway

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7 January 2021

A Diels-Alder macrocyclization enables an efficient asymmetric synthesis of the antibacterial natural product abyssomicin C

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7 January 2021

Lessons from natural molecules

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7 January 2021

Exploring nitrilase sequence space for enantioselective catalysis

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7 January 2021

Identifiers

DOI

10.1038/NBT1266

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Dimensions Publication ID

15 August 2017

1025744289

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