The genetics of Parkinson disease: Implications for neurological care (Q36577255)

15 August 2017

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title

The genetics of Parkinson disease: Implications for neurological care (English)

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15 August 2017

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1

Christine Klein

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15 August 2017

author name string

Michael G Schlossmacher

series ordinal

2

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15 August 2017

publication date

1 March 2006

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Nature Clinical Practice Neurology

15 August 2017

published in

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15 August 2017

volume

2

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15 August 2017

issue

3

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15 August 2017

page(s)

136-146

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Autosomal dominant parkinsonism associated with variable synuclein and tau pathology

15 August 2017

cites work

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Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

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PINK1 (PARK6) associated Parkinson disease in Ireland

21 January 2018

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DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease

21 January 2018

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Apolipoprotein E controls the risk and age at onset of Parkinson disease

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Variability and validity of polymorphism association studies in Parkinson's disease

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SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders

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7 January 2021

Parkinson's disease. First of two parts

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7 January 2021

Parkinson's disease. Second of two parts

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7 January 2021

Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages).

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7 January 2021

How much phenotypic variation can be attributed to parkin genotype?

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

The PINK1 phenotype can be indistinguishable from idiopathic Parkinson disease

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7 January 2021

Lewy bodies and parkinsonism in families with parkin mutations

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7 January 2021

Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers

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7 January 2021

Movement disorders: classifications

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7 January 2021

Role of parkin mutations in 111 community-based patients with early-onset parkinsonism

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7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

Distribution, type, and origin of Parkin mutations: review and case studies

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7 January 2021

The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin

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7 January 2021

The biochemistry of Parkinson's disease

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7 January 2021

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

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7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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7 January 2021

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

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7 January 2021

A Drosophila model of Parkinson's disease

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7 January 2021

Dopamine covalently modifies and functionally inactivates parkin

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7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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7 January 2021

PINK1 mutations are associated with sporadic early-onset parkinsonism

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes

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7 January 2021

PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism

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7 January 2021

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

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7 January 2021

Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

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7 January 2021

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Alpha-synuclein and Parkinson's disease: Implications from the screening of more than 1,900 patients

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Neurobiology of alpha-synuclein

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses

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7 January 2021

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 27-2004. A 79-year-old woman with disturbances in gait, cognition, and autonomic function

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7 January 2021

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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7 January 2021

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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7 January 2021

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

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7 January 2021

A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

LRRK2 mutations in Parkinson disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

LRRK2 gene in Parkinson disease: Mutation analysis and case control association study

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7 January 2021

Lrrk2 pathogenic substitutions in Parkinson's disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Parkin variants in North American Parkinson's disease: cases and controls.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Brain parenchyma sonography detects preclinical parkinsonism.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Linkage disequilibrium and association of MAPT H1 in Parkinson disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

The glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

UCHL1 is a Parkinson's disease susceptibility gene

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Association between early-onset Parkinson's disease and mutations in the parkin gene

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Genetic testing in Parkinson's disease

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

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https://api.crossref.org/works/10.1038%2FNCPNEURO0126

7 January 2021

Identifiers

DOI

10.1038/NCPNEURO0126

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15 August 2017

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