Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (Q36558024)

14 August 2017

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title

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy (English)

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14 August 2017

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Fulda S

1

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14 August 2017

Debatin KM

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

1 August 2006

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14 August 2017

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14 August 2017

volume

25

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14 August 2017

issue

34

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14 August 2017

page(s)

4798-4811

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Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

14 August 2017

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Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL

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AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

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Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy

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7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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7 January 2021

Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4

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7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

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7 January 2021

Mitochondrion as a novel target of anticancer chemotherapy

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7 January 2021

Unraveling biologic therapy for Bcl-2-expressing malignancies

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7 January 2021

Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain

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Signal transduction by the JNK group of MAP kinases

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Chemotherapy: targeting the mitochondrial cell death pathway

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7 January 2021

Apoptosis in hematological disorders.

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7 January 2021

Mutation analysis of the apoptotic "death-receptors" and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines

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7 January 2021

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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7 January 2021

Bim is a suppressor of Myc-induced mouse B cell leukemia

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7 January 2021

Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells

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7 January 2021

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

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7 January 2021

Targeting apoptosis pathways in cancer therapy

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7 January 2021

Chemosensitivity of solid tumor cellsin vitro is related to activation of the CD95 system

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7 January 2021

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

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7 January 2021

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

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7 January 2021

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

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7 January 2021

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The pathophysiology of mitochondrial cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

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7 January 2021

Suppression of tumorigenesis by the p53 target PUMA

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7 January 2021

The biochemistry of apoptosis

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7 January 2021

Thymineless death in colon carcinoma cells is mediated via Fas signaling

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7 January 2021

Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac

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7 January 2021

Intracellular Fas ligand expression causes Fas-mediated apoptosis in human prostate cancer cells resistant to monoclonal antibody-induced apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

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7 January 2021

Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

NF-kappaB in cancer: from innocent bystander to major culprit

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7 January 2021

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Cisplatin (CDDP) sensitizes human osteosarcoma cell to Fas/CD95-mediated apoptosis by down-regulating FLIP-L expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Dysregulation of apoptosis genes in hematopoietic malignancies.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

CD95's deadly mission in the immune system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Apo2L/TRAIL and its death and decoy receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

c-FLIP inhibits chemotherapy-induced colorectal cancer cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Epigenetic changes in tumor Fas levels determine immune escape and response to therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Histone deacetylases and cancer: causes and therapies

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Expression of Smac/DIABLO in ovarian carcinoma cells induces apoptosis via a caspase-9-mediated pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

p53 has a direct apoptogenic role at the mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2/Bcl-XL bispecific antisense oligonucleotides in HER-2 gene--amplified breast cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Transcription-independent pro-apoptotic functions of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Apoptotic DNA fragmentation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Pathways of apoptotic and non-apoptotic death in tumour cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Generation and characterization of Smac/DIABLO-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Defying death after DNA damage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Distinct pathways for stimulation of cytochrome c release by etoposide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Toxic proteins released from mitochondria in cell death

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

BID regulation by p53 contributes to chemosensitivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Two CD95 (APO-1/Fas) signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

PED mediates AKT-dependent chemoresistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The role of BH3-only proteins in the immune system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Structure-based design of potent, conformationally constrained Smac mimetics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Mitochondrially targeted p53 has tumor suppressor activities in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Mammalian mitochondrial IAP binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Transfection of Smac sensitizes tumor cells to etoposide-induced apoptosis and eradicates established human hepatoma in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209608

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209608

1 reference

14 August 2017

1 reference