Early nonsense: mRNA decay solves a translational problem (Q36488710)

14 August 2017

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title

Early nonsense: mRNA decay solves a translational problem (English)

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14 August 2017

Matthew S Sachs

2

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author name string

Nadia Amrani

series ordinal

1

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14 August 2017

Allan Jacobson

series ordinal

3

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14 August 2017

publication date

1 June 2006

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Nature Reviews Molecular Cell Biology

14 August 2017

published in

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14 August 2017

volume

7

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14 August 2017

issue

6

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14 August 2017

page(s)

415-425

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Turnover mechanisms of the stable yeast PGK1 mRNA

14 August 2017

cites work

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Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant

21 January 2018

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Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway

21 January 2018

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Gene products that promote mRNA turnover in Saccharomyces cerevisiae

21 January 2018

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Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein

21 January 2018

1 reference

Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover

21 January 2018

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The majority of yeast UPF1 co-localizes with polyribosomes in the cytoplasm

21 January 2018

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Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping

21 January 2018

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Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay

21 January 2018

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Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover

21 January 2018

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Initiation of translation can occur only in a restricted region of the CYC1 mRNA of Saccharomyces cerevisiae

21 January 2018

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Eukaryotic translation initiation factors and regulators

21 January 2018

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Cap-dependent and cap-independent translation in eukaryotic systems

31 March 2020

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Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression

31 March 2020

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The molecular mechanics of eukaryotic translation

31 March 2020

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Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G

31 March 2020

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The end justifies the means

31 March 2020

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Making sense of mimic in translation termination

31 March 2020

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Mimicry grasps reality in translation termination

31 March 2020

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Emerging understanding of translation termination

31 March 2020

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A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor

31 March 2020

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The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae

31 March 2020

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Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3

31 March 2020

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The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein

31 March 2020

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Poly(A)-binding protein and eRF3 are associated in vivo in human and Xenopus cells

31 March 2020

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Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation

31 March 2020

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A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation

31 March 2020

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Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics

31 March 2020

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Transcript selection and the recruitment of mRNA decay factors for NMD in Saccharomyces cerevisiae

31 March 2020

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mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans

31 March 2020

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A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

31 March 2020

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Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast

31 March 2020

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Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant

31 March 2020

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An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA.

31 March 2020

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Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance

31 March 2020

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A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation

31 March 2020

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Model for Quantitative and Qualitative Control of mRNA Translation in Eukaryotes

31 March 2020

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A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation

31 March 2020

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Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay

31 March 2020

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The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways

31 March 2020

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The enzymes and control of eukaryotic mRNA turnover

31 March 2020

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General translational repression by activators of mRNA decapping

31 March 2020

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Processing bodies require RNA for assembly and contain nontranslating mRNAs

31 March 2020

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Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies

31 March 2020

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Computational modeling of eukaryotic mRNA turnover

31 March 2020

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The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex

31 March 2020

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Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs

31 March 2020

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Functional analysis of mRNA scavenger decapping enzymes

31 March 2020

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Decapping the message: a beginning or an end.

31 March 2020

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Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping

31 March 2020

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Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.

31 March 2020

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RNA degradation by the exosome is promoted by a nuclear polyadenylation complex

31 March 2020

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Crosstalk between RNA metabolic pathways: an RNOMICS approach

31 March 2020

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A nuclear surveillance pathway for mRNAs with defective polyadenylation.

31 March 2020

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An mRNA surveillance mechanism that eliminates transcripts lacking termination codons

31 March 2020

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Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway

31 March 2020

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Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

31 March 2020

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Nonsense-mediated mRNA decay: molecular insights and mechanistic variations across species

31 March 2020

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Premature translational termination triggers mRNA decapping

31 March 2020

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Computational modeling and experimental analysis of nonsense-mediated decay in yeast

31 March 2020

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A Sm-like protein complex that participates in mRNA degradation

31 March 2020

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The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

31 March 2020

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A genetic screen identifies cellular factors involved in retroviral -1 frameshifting

31 March 2020

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Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon

31 March 2020

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Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen

31 March 2020

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Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p

31 March 2020

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Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae

31 March 2020

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The case against the involvement of the NMD proteins in programmed frameshifting

31 March 2020

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Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

31 March 2020

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

31 March 2020

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The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts

31 March 2020

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Relationship between Yeast Polyribosomes and Upf Proteins Required for Nonsense mRNA Decay

31 March 2020

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Linking mRNA turnover and translation: assessing the polyribosomal association of mRNA decay factors and degradative intermediates.

31 March 2020

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Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA

31 March 2020

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Nonsense suppressors partially revert the decrease of the mRNA level of a nonsense mutant allele in yeast

31 March 2020

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Interference of nonsense mutations with eukaryotic messenger RNA stability

31 March 2020

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Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay

31 March 2020

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Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans

31 March 2020

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Regulation of mRNA translation by 5'- and 3'-UTR-binding factors

31 March 2020

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Regulation of cap-dependent translation by eIF4E inhibitory proteins

31 March 2020

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AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors

31 March 2020

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The search for trans-acting factors controlling messenger RNA decay.

31 March 2020

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Formation of the 3' end of histone mRNA

31 March 2020

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Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution

31 March 2020

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mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

31 March 2020

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mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor

31 March 2020

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A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus

31 March 2020

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The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames

31 March 2020

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mRNA surveillance in mammalian cells: the relationship between introns and translation termination

31 March 2020

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The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay

31 March 2020

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Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

31 March 2020

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

31 March 2020

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eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay

31 March 2020

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The ever-increasing complexities of the exon junction complex

31 March 2020

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Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes

31 March 2020

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Translation of aberrant mRNAs lacking a termination codon or with a shortened 3'-UTR is repressed after initiation in yeast

31 March 2020

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Translation termination factor eRF3 mediates mRNA decay through the regulation of deadenylation.

31 March 2020

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Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay

31 March 2020

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Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay

31 March 2020

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Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies

31 March 2020

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A perfect message: RNA surveillance and nonsense-mediated decay

31 March 2020

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RNA splicing promotes translation and RNA surveillance

31 March 2020

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The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

31 March 2020

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Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

31 March 2020

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A new function for nonsense-mediated mRNA-decay factors

31 March 2020

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Exon junction complexes mediate the enhancing effect of splicing on mRNA expression

31 March 2020

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Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

31 March 2020

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Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

31 March 2020

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An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

31 March 2020

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The protein Mago provides a link between splicing and mRNA localization.

31 March 2020

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Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1

31 March 2020

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Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay

31 March 2020

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EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length

31 March 2020

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Inhibition of translation termination mediated by an interaction of eukaryotic release factor 1 with a nascent peptidyl-tRNA.

31 March 2020

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Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination

31 March 2020

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A newly discovered function for RNase L in regulating translation termination

31 March 2020

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Driving change: the evolution of alternative genetic codes.

31 March 2020

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Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes

31 March 2020

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SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans

31 March 2020

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Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

31 March 2020

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Selection of the initiator tRNA by Escherichia coli initiation factors.

31 March 2020

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Conversion of 48S translation preinitiation complexes into 80S initiation complexes as revealed by toeprinting.

31 March 2020

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Primer extension analysis of eukaryotic ribosome-mRNA complexes

31 March 2020

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Toeprint analysis of the positioning of translation apparatus components at initiation and termination codons of fungal mRNAs

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1942

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14 August 2017

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