New players in TLR-mediated innate immunity: PI3K and small Rho GTPases. (Q36487072)

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28 January 2020

review article

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title

New players in TLR-mediated innate immunity: PI3K and small Rho GTPases (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16720897%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

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28 January 2020

author name string

Monica Ruse

series ordinal

1

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publication date

1 January 2006

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28 January 2020

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28 January 2020

volume

34

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28 January 2020

issue

1

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28 January 2020

page(s)

33-48

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Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus

28 January 2020

cites work

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12 December 2020

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta

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The role of PI3K in immune cells

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PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

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Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

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TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation

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Signalling by PI3K isoforms: insights from gene-targeted mice.

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Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP.

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Phosphoinositide 3-kinase: diverse roles in immune cell activation

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Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages

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Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

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Phosphoinositide 3-kinase in immunological systems

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Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

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PI 3-kinase p110beta: a new target for antithrombotic therapy

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Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways

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Mevastatin suppresses lipopolysaccharide-induced Rac activation in the human monocyte cell line THP-1.

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Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages

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Phosphoinositide 3-kinases as targets for therapeutic intervention

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

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SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells

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12 December 2020

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

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12 December 2020

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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12 December 2020

Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta

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12 December 2020

Discrimination of bacterial lipoproteins by Toll-like receptor 6

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Rac1 and Toll-IL-1 receptor domain-containing adapter protein mediate Toll-like receptor 4 induction of HIV-long terminal repeat

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Regulation of innate immunity by Rho GTPases

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12 December 2020

Toll-like receptors in innate immunity

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Toll-like receptors stimulate human neutrophil function

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Viruses and interferons

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P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils

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TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.

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12 December 2020

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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12 December 2020

Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts

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12 December 2020

p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration

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12 December 2020

Cutting Edge: CpG DNA inhibits dendritic cell apoptosis by up-regulating cellular inhibitor of apoptosis proteins through the phosphatidylinositide-3'-OH kinase pathway.

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12 December 2020

Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil

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12 December 2020

Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils

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12 December 2020

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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12 December 2020

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

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12 December 2020

Innate immunity and arthritis: neutrophil Rac and toll-like receptor 4 expression define outcomes in infection-triggered arthritis

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12 December 2020

Pathogen recognition with Toll-like receptors

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12 December 2020

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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12 December 2020

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense

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12 December 2020

IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription

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12 December 2020

Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA.

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12 December 2020

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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12 December 2020

TIR domain-containing adaptors define the specificity of TLR signaling

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12 December 2020

Regulation of neutrophil function by Rac GTPases

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12 December 2020

Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils.

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12 December 2020

The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells

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12 December 2020

The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages

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12 December 2020

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

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12 December 2020

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

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12 December 2020

LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

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12 December 2020

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

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12 December 2020

Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.

1 reference

12 December 2020

Wortmannin, a Specific Inhibitor of Phosphatidylinositol-3-kinase, Enhances LPS-Induced NO Production from Murine Peritoneal Macrophages

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12 December 2020

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway

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12 December 2020

A novel protein kinase C (PKCepsilon) is required for fMet-Leu-Phe-induced activation of NF-kappaB in human peripheral blood monocytes

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12 December 2020

Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1. Regulation by Rho and phosphatidylinositol 3-kinase

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12 December 2020

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

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12 December 2020

Inferences, questions and possibilities in Toll-like receptor signalling

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12 December 2020

PI3K-mediated negative feedback regulation of IL-12 production in DCs

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12 December 2020

Rac2 is critical for neutrophil primary granule exocytosis.

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12 December 2020

Bacterial toxins that modify the actin cytoskeleton

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12 December 2020

Rho-family GTPases: it's not only Rac and Rho (and I like it).

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12 December 2020

Negative regulation of toll-like receptor-mediated immune responses

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12 December 2020

Toll-like receptor signalling

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12 December 2020

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

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12 December 2020

Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt.

1 reference

12 December 2020

The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription

1 reference

12 December 2020

Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

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12 December 2020

The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults

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12 December 2020

Of mice and men: species variations of Toll-like receptor expression

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12 December 2020

Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain

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12 December 2020

Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

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12 December 2020

Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad

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12 December 2020

The p21 GTP-binding proteins and bacterial toxins

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12 December 2020

Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury.

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12 December 2020

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

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12 December 2020

Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1

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12 December 2020

Immunobiology of dendritic cells

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12 December 2020

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins

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12 December 2020

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

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12 December 2020

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

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12 December 2020

Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.

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12 December 2020

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

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12 December 2020

The role of Rac1 and Rac2 in bacterial killing

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12 December 2020

Phosphoinositide 3-kinase-dependent activation of Rac.

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12 December 2020

Rho GTPases: biochemistry and biology

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12 December 2020

Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles

1 reference

12 December 2020

Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages

1 reference

12 December 2020

PI3K and negative regulation of TLR signaling.

1 reference

12 December 2020

Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4.

1 reference

12 December 2020

Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages

1 reference

12 December 2020

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

1 reference

12 December 2020

Activation of phosphatidylinositol 3-kinase and c-Jun-N-terminal kinase cascades enhances NF-kappaB-dependent gene transcription in BCG-stimulated macrophages through promotion of p65/p300 binding

1 reference

12 December 2020

Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.

1 reference

12 December 2020