Cytochrome P450 pharmacogenetics and cancer. (Q36426794)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16550168%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

review article

1 reference

title

Cytochrome P450 pharmacogenetics and cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16550168%20AND%20SRC:MED&resulttype=core&format=json

Cristina Rodríguez-Antona

18 January 2020

author

series ordinal

1

1 reference

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18 January 2020

author name string

Ingelman-Sundberg M

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16550168%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

0 references

publication date

1 March 2006

1 reference

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18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16550168%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

25

1 reference

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18 January 2020

issue

11

1 reference

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18 January 2020

page(s)

1679-1691

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Cytochrome P450 gene polymorphism and cancer

18 January 2020

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Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort

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Clinical significance of the cytochrome P450 2C19 genetic polymorphism

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Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma

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Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers

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Effect of cytochrome P450 3A4 inhibition on the pharmacokinetics of docetaxel

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Irinotecan therapy in adults with recurrent or progressive malignant glioma

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Inter-gene correlation on oligonucleotide arrays: how much does normalization matter?

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Expression of cytochrome P450 in lung tumor

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Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

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Role of gene knockout and transgenic mice in the study of xenobiotic metabolism

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7 January 2021

In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study.

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7 January 2021

Unexpected association between induction of immunity to the universal tumor antigen CYP1B1 and response to next therapy.

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7 January 2021

Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype

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7 January 2021

Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2.

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7 January 2021

The aryl hydrocarbon receptor complex

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7 January 2021

Isolation, structural determination, and biological activity of 6 alpha-hydroxytaxol, the principal human metabolite of taxol

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7 January 2021

Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

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7 January 2021

Association of CYP2C8, CYP3A4, CYP3A5, and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel

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7 January 2021

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes

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7 January 2021

Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model

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7 January 2021

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

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7 January 2021

Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms

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7 January 2021

Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future

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7 January 2021

Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity

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7 January 2021

Pharmacogenetics of drug-metabolizing enzymes: implications for a safer and more effective drug therapy

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7 January 2021

Cytochrome P450 isozymes 3A4 and 2B6 are involved in the in vitro human metabolism of thiotepa to TEPA.

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7 January 2021

Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors

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CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

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Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

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7 January 2021

A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity

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Patient-tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes

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7 January 2021

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Clinical consequences of cytochrome P450 2C9 polymorphisms

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.

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7 January 2021

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver

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7 January 2021

Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles

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7 January 2021

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups

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7 January 2021

Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo

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7 January 2021

Substrates of human hepatic cytochrome P450 3A4.

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7 January 2021

Modification of ocular defects in mouse developmental glaucoma models by tyrosinase

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7 January 2021

Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma.

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7 January 2021

Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence.

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7 January 2021

The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.

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7 January 2021

Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review

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7 January 2021

Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes

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7 January 2021

Effects of St. John's wort on irinotecan metabolism

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7 January 2021

Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1

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7 January 2021

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer

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7 January 2021

Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.

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7 January 2021

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain

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7 January 2021

Prediction of response to docetaxel by CYP3A4 mRNA expression in breast cancer tissues

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7 January 2021

Prediction of response to docetaxel by immunohistochemical analysis of CYP3A4 expression in human breast cancers

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7 January 2021

Pharmacokinetics of paclitaxel in ovarian cancer patients and genetic polymorphisms of CYP2C8, CYP3A4, and MDR1.

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7 January 2021

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7 January 2021

Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer

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7 January 2021

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

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7 January 2021

Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide

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7 January 2021

Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population

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7 January 2021

Expression of cytochrome P450 in tumor tissues and its association with cancer development.

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7 January 2021

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

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7 January 2021

The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1.

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7 January 2021

Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids

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7 January 2021

Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism

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7 January 2021

The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors

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7 January 2021

Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

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7 January 2021

Cancer chemotherapy and drug metabolism.

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7 January 2021

Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma

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7 January 2021

Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles

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7 January 2021

Enzyme-catalyzed activation of anticancer prodrugs

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7 January 2021

Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

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7 January 2021

Conditional regulation of the human CYP4X1 and CYP4Z1 genes

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7 January 2021

CYP3A7 protein expression is high in a fraction of adult human livers and partially associated with the CYP3A7*1C allele

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7 January 2021

The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer

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7 January 2021

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis

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7 January 2021

Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes

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7 January 2021

Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4.

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7 January 2021

CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia

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7 January 2021

Association of cyclophosphamide pharmacokinetics to polymorphic cytochrome P450 2C19

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7 January 2021

Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer

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7 January 2021

Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

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7 January 2021

The relationship between polymorphisms of xenobiotic metabolizing enzymes and susceptibility to cancer

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7 January 2021

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

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7 January 2021

3'-UTR polymorphism in the human CYP2A6 gene affects mRNA stability and enzyme expression

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7 January 2021

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

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7 January 2021

Baculovirus vectors: novel mammalian cell gene-delivery vehicles and their applications

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7 January 2021

Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol

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7 January 2021

Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms

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7 January 2021

Quantitation of cytochrome P450 mRNA levels in human skin

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7 January 2021

Potential role for human cytochrome P450 3A4 in estradiol homeostasis

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7 January 2021