Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components (Q36399113)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15173209%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components (English)

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29 December 2019

1

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29 December 2019

Inga-Lill Martensson

5

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29 December 2019

author name string

Cornelia Mundt

2

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29 December 2019

Mathew Parker

3

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29 December 2019

Roberta Pelanda

4

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29 December 2019

Thomas H Winkler

6

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29 December 2019

language of work or name

English

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publication date

1 June 2004

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Journal of Experimental Medicine

29 December 2019

published in

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29 December 2019

volume

199

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29 December 2019

issue

11

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29 December 2019

page(s)

1523-1532

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The transcription cycle of RNA polymerase II in living cells.

29 December 2019

cites work

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30 September 2017

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B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta

30 September 2017

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The mechanism and regulation of chromosomal V(D)J recombination

30 September 2017

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Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes.

30 September 2017

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The VpreB protein of the surrogate light-chain can pair with some mu heavy-chains in the absence of the lambda 5 protein

30 September 2017

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Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor

30 September 2017

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Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production

30 September 2017

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

30 September 2017

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Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells

30 September 2017

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The surrogate light chain in mouse B-cell development

30 September 2017

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The murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell development

30 September 2017

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A novel gene product associated with mu chains in immature B cells

30 September 2017

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Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

30 September 2017

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The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver

30 September 2017

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Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage

30 September 2017

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Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors

30 September 2017

1 reference

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Ordered rearrangement of immunoglobulin heavy chain variable region segments

30 September 2017

1 reference

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Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

30 September 2017

1 reference

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Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires

30 September 2017

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Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface

30 September 2017

1 reference

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Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement

30 September 2017

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Identification of a pre-BCR lacking surrogate light chain

30 September 2017

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Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice

28 June 2018

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Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice

28 June 2018

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Chromatin interaction mechanism of transcriptional control in vivo

28 June 2018

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A transgenic marker for mouse B lymphoid precursors

28 June 2018

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A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines

28 June 2018

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Immunoglobulin heavy chain and binding protein complexes are dissociated in vivo by light chain addition

28 June 2018

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Analysis of VpreB expression during B lineage differentiation in lambda5-deficient mice.

28 June 2018

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A critical role of λ5 protein in B cell development

21 January 2018

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A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

21 January 2018

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Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion

21 January 2018

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Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

21 January 2018

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Asynchronous replication and allelic exclusion in the immune system

21 January 2018

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The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

21 January 2018

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12 December 2020

IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development

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12 December 2020

Assembled pre-B cell receptor complexes are retained in the endoplasmic reticulum by a mechanism that is not selective for the pseudo-light chain

1 reference

12 December 2020

Down-regulation of terminal deoxynucleotidyl transferase by Ig heavy chain in B lineage cells

1 reference

12 December 2020

VpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus

1 reference

12 December 2020

Single-cell gene expression profiling

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12 December 2020

Identifiers

DOI

10.1084/JEM.20031523

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15173209%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15173209%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

15173209

1 reference