An APRIL to remember: novel TNF ligands as therapeutic targets (Q36394955)

13 August 2017

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title

An APRIL to remember: novel TNF ligands as therapeutic targets (English)

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13 August 2017

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Stacey R Dillon

1

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13 August 2017

Jane A Gross

series ordinal

2

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13 August 2017

Stephen M Ansell

series ordinal

3

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13 August 2017

Anne J Novak

series ordinal

4

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13 August 2017

publication date

1 March 2006

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Nature Reviews Drug Discovery

13 August 2017

published in

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13 August 2017

volume

5

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13 August 2017

issue

3

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13 August 2017

page(s)

235-246

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The molecular architecture of the TNF superfamily

13 August 2017

cites work

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APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth

21 January 2018

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BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator

21 January 2018

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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

21 January 2018

1 reference

Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase

21 January 2018

1 reference

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

21 January 2018

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NF-AT Activation Induced by a CAML-Interacting Member of the Tumor Necrosis Factor Receptor Superfamily

21 January 2018

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BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes

21 January 2018

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BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

21 January 2018

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Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency

21 January 2018

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Identification of proteoglycans as the APRIL-specific binding partners.

21 January 2018

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Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation.

21 January 2018

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BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases

21 January 2018

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The biochemistry and biology of BAFF, APRIL and their receptors

21 January 2018

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The BAFF/APRIL system: an important player in systemic rheumatic diseases

21 January 2018

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The role of BAFF in immune function and implications for autoimmunity

21 January 2018

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The BAFF/APRIL system: life beyond B lymphocytes.

21 January 2018

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The role of APRIL and BAFF in lymphocyte activation

21 January 2018

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CD molecules 2005: human cell differentiation molecules.

21 January 2018

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An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein

21 January 2018

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The crystal structure of a proliferation-inducing ligand, APRIL.

21 January 2018

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Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase

21 January 2018

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TWE-PRIL; a fusion protein of TWEAK and APRIL

21 January 2018

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Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity

21 January 2018

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Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI

21 January 2018

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Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS

21 January 2018

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APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity

21 January 2018

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Ligand-receptor binding revealed by the TNF family member TALL-1

21 January 2018

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Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding

21 January 2018

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BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site

21 January 2018

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Crystal structure of the BAFF–BAFF-R complex and its implications for receptor activation

21 January 2018

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Engineering an APRIL-specific B cell maturation antigen

21 January 2018

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The TNF family members BAFF and APRIL: the growing complexity

21 January 2018

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A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth

21 January 2018

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Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity

21 January 2018

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Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex

21 January 2018

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The CD40-CD154 interaction in B cell-T cell liaisons

21 January 2018

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Syndecans: proteoglycan regulators of cell-surface microdomains?

21 January 2018

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Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA.

21 January 2018

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DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL

21 January 2018

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Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF.

21 January 2018

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The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature

21 January 2018

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Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines.

21 January 2018

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Abnormal production of the TNF-homologue APRIL increases the proliferation of human malignant glioblastoma cell lines via a specific receptor

21 January 2018

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Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.

21 January 2018

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Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome.

21 January 2018

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Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival

21 January 2018

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Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL.

21 January 2018

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BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone

21 January 2018

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Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha

21 January 2018

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B-lymphocytes, innate immunity, and autoimmunity

21 January 2018

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B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells

21 January 2018

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The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed

21 January 2018

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BLyS and APRIL in rheumatoid arthritis

21 January 2018

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BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses

21 January 2018

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APRIL modulates B and T cell immunity

21 January 2018

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Impaired IgA class switching in APRIL-deficient mice

21 January 2018

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BAFF selectively enhances the survival of plasmablasts generated from human memory B cells.

21 January 2018

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BCMA is essential for the survival of long-lived bone marrow plasma cells

21 January 2018

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B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells

21 January 2018

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TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase

21 January 2018

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Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis.

21 January 2018

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APRIL-deficient mice have normal immune system development

21 January 2018

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APRIL promotes B-1 cell-associated neoplasm.

21 January 2018

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Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen.

21 January 2018

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Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor

21 January 2018

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B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses

21 January 2018

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An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

21 January 2018

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B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation.

21 January 2018

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The role of B cells and accessory cells in the neonatal response to TI-2 antigens

21 January 2018

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TACI and BAFF-R mediate isotype switching in B cells

21 January 2018

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Raised serum APRIL levels in patients with systemic lupus erythematosus

21 January 2018

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Inverse association between circulating APRIL levels and serological and clinical disease activity in patients with systemic lupus erythematosus

21 January 2018

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A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus

21 January 2018

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Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis

21 January 2018

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Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases.

21 January 2018

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Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome

21 January 2018

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The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome

21 January 2018

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Increased levels of APRIL (a proliferation-inducing ligand) mRNA in multiple sclerosis.

21 January 2018

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Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis

21 January 2018

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Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans.

21 January 2018

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TACI is mutant in common variable immunodeficiency and IgA deficiency

21 January 2018

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APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis

21 January 2018

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Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization

21 January 2018

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BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway

21 January 2018

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Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator

21 January 2018

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Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF.

21 January 2018

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Mechanism of Action of Transmembrane Activator and Calcium Modulator Ligand Interactor-Ig in Murine Systemic Lupus Erythematosus

21 January 2018

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TALL-1 is a novel member of the TNF family that is down-regulated by mitogens

21 January 2018

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Synthesis and release of B-lymphocyte stimulator from myeloid cells

31 March 2020

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Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival

31 March 2020

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TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS

31 March 2020

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Regulation of the T-independent humoral response by TACI

31 March 2020

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Activation and accumulation of B cells in TACI-deficient mice

31 March 2020

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The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching

31 March 2020

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Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus

31 March 2020

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TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice

31 March 2020

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Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome

31 March 2020

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Unveiling the enigma of the CNS as a B-cell fostering environment

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1982

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13 August 2017

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