Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens. (Q36370873)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12163561%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens (English)

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11 November 2019

1

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11 November 2019

Linda A Sherman

series ordinal

4

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11 November 2019

author name string

Sandra Aung

series ordinal

2

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11 November 2019

Kristi Marquardt

series ordinal

3

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11 November 2019

language of work or name

English

0 references

publication date

1 August 2002

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Journal of Experimental Medicine

11 November 2019

published in

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11 November 2019

volume

196

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11 November 2019

issue

3

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11 November 2019

page(s)

323-333

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Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen.

11 November 2019

cites work

1 reference

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CD40 stimulation accelerates deletion of tumor-specific CD8(+) T cells in the absence of tumor-antigen vaccination

30 September 2017

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Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

30 September 2017

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30 September 2017

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Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo

30 September 2017

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30 September 2017

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30 September 2017

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CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes

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30 September 2017

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CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose

30 September 2017

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30 September 2017

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Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen

30 September 2017

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Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens

30 September 2017

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Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

30 September 2017

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CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

30 September 2017

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Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

30 September 2017

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

30 September 2017

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High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

30 September 2017

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A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis

30 September 2017

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Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity

30 September 2017

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A fail-safe mechanism for maintaining self-tolerance

30 September 2017

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Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay

30 September 2017

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CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal

30 September 2017

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A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes

28 June 2018

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Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells

28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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28 June 2018

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

21 January 2018

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Help for cytotoxic-T-cell responses is mediated by CD40 signalling

21 January 2018

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T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

21 January 2018

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Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy.

21 January 2018

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21 January 2018

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21 January 2018

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Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses.

21 January 2018

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Adjuvant effect of IL-12: conversion of peptide antigen administration from tolerizing to immunizing for CD8+ T cells in vivo.

21 January 2018

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Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity.

21 September 2018

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CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism

21 September 2018

1 reference

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CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy

21 October 2018

1 reference

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Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells

21 January 2018

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Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells

5 December 2018

1 reference

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Characterization of CD8+ T Lymphocytes That Persist After Peripheral Tolerance to a Self Antigen Expressed in the Pancreas

21 January 2018

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Antigen‐presenting cells in adoptively transferred and spontaneous autoimmune diabetes

21 January 2018

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CD4+8- help prevents rapid deletion of CD8+ cells after a transient response to antigen

21 January 2018

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IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production

21 January 2018

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Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production

21 January 2018

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12 December 2020

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice

1 reference

12 December 2020

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production

1 reference

12 December 2020

Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity

1 reference

12 December 2020

Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens

1 reference

12 December 2020

Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division

1 reference

12 December 2020

T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms

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12 December 2020

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

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12 December 2020

Identifiers

DOI

10.1084/JEM.20011612

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12163561%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12163561%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

PubMed publication ID

12163561

1 reference