Mitochondrial uncoupling proteins in the CNS: in support of function and survival. (Q36285974)

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8 January 2020

review article

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title

Mitochondrial uncoupling proteins in the CNS: in support of function and survival (English)

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8 January 2020

1

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8 January 2020

author name string

Sabrina Diano

series ordinal

2

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8 January 2020

Tamas L Horvath

series ordinal

3

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8 January 2020

language of work or name

English

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publication date

1 November 2005

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Nature Reviews Neuroscience

8 January 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16224498%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

6

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8 January 2020

issue

11

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8 January 2020

page(s)

829-840

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The mitochondrial uncoupling-protein homologues

8 January 2020

cites work

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Brown adipose tissue: function and physiological significance

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

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Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression

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UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells

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BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast

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Vectorial metabolism and the evolution of transport systems

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Uncoupling protein 2 in the brain: distribution and function

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Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary

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Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers.

31 March 2020

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Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

31 March 2020

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BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production

31 March 2020

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Uncoupling protein 2 influences dopamine secretion in PC12h cells

31 March 2020

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

31 March 2020

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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

31 March 2020

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Dynamics of volume transmission in the brain. Focus on catecholamine and opioid peptide communication and the role of uncoupling protein 2.

31 March 2020

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Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

31 March 2020

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Glutamate-induced neuron death requires mitochondrial calcium uptake

31 March 2020

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Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes

31 March 2020

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Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning.

31 March 2020

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Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid vs. glucose oxidation.

31 March 2020

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Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.

31 March 2020

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Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo

31 March 2020

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

31 March 2020

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Cardiovascular risk factors emerge after artificial selection for low aerobic capacity

31 March 2020

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High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

31 March 2020

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Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death.

31 March 2020

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A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation

31 March 2020

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Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death

31 March 2020

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Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

31 March 2020

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Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation

31 March 2020

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Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis

31 March 2020

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Superoxide activates mitochondrial uncoupling proteins

31 March 2020

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Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants

31 March 2020

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A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.

31 March 2020

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No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.

31 March 2020

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Pathways towards and away from Alzheimer's disease

31 March 2020

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The effects of cooling and rewarming on the neuronal activity of pyramidal neurons in guinea pig hippocampal slices

31 March 2020

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Thermoregulation with age: role of thermogenesis and uncoupling protein expression in brown adipose tissue

31 March 2020

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Redox mechanisms at the glutamate synapse and their significance: a review

31 March 2020

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The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

31 March 2020

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Uncoupling protein 2 in primary pain and temperature afferents of the spinal cord

31 March 2020

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Spinal dorsal horn neurone targets for nociceptive primary afferents: do single neurone morphological characteristics suggest how nociceptive information is processed at the spinal level

31 March 2020

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Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold

31 March 2020

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ATP, P2X receptors and pain pathways

31 March 2020

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The genetic mediation of individual differences in sensitivity to pain and its inhibition

31 March 2020

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Epilepsy and apoptosis pathways

31 March 2020

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Requirement for superoxide in excitotoxic cell death

31 March 2020

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Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

31 March 2020

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Involvement of free radicals in excitotoxicity in vivo.

31 March 2020

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Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses.

31 March 2020

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Mitochondria and neuronal glutamate excitotoxicity

31 March 2020

1 reference

Pre- or post-treatment with the mitochondrial uncoupler 2,4-dinitrophenol attenuates striatal quinolinate lesions

31 March 2020

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Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat.

31 March 2020

1 reference

Superoxide dismutase, glutathione peroxidase activities and the hydroperoxide concentration are modified in the hippocampus of epileptic rats

31 March 2020

1 reference

Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha-phenylnitrone or vitamin E.

31 March 2020

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Cellular pathology of hilar neurons in Ammon's horn sclerosis

31 March 2020

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Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain

31 March 2020

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Genetic determinants of susceptibility to excitotoxic cell death: implications for gene targeting approaches

31 March 2020

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Mitochondrial uncoupling as a therapeutic target following neuronal injury

31 March 2020

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Unprovoked seizures and developmental disabilities: clinical characteristics of children referred to a child development center

31 March 2020

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The prevalence and incidence of convulsive disorders in children

31 March 2020

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Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats.

31 March 2020

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The ketogenic diet increases mitochondrial uncoupling protein levels and activity

31 March 2020

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Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity

31 March 2020

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Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

31 March 2020

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Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

31 March 2020

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31 March 2020

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Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants

31 March 2020

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Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10

31 March 2020

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Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury

31 March 2020

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Traumatic brain injury alters synaptic homeostasis: implications for impaired mitochondrial and transport function

31 March 2020

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Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury.

31 March 2020

1 reference

Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels

31 March 2020

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Protein aggregation and neurodegenerative disease

31 March 2020

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The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment

31 March 2020

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Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia?

31 March 2020

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Familial amyotrophic lateral sclerosis

31 March 2020

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

31 March 2020

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Mitochondrial involvement in amyotrophic lateral sclerosis

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Mitochondria, oxidants, and aging

31 March 2020

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Aging: a theory based on free radical and radiation chemistry

31 March 2020

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Parkinson's disease: mechanisms and models

31 March 2020

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Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice

31 March 2020

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Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

31 March 2020

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Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

31 March 2020

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Uncoupling to survive? The role of mitochondrial inefficiency in ageing

31 March 2020

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Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

31 March 2020

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Coenzyme Q is an obligatory cofactor for uncoupling protein function

31 March 2020

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The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3.

31 March 2020

1 reference

Transport function and regulation of mitochondrial uncoupling proteins 2 and 3

31 March 2020

1 reference

Regulation of UCP3 by nucleotides is different from regulation of UCP1

31 March 2020

1 reference

Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10.

31 March 2020

1 reference

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

31 March 2020

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