Keynote review: the adipocyte as a drug discovery target (Q36280813)

13 August 2017

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title

Keynote review: the adipocyte as a drug discovery target (English)

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13 August 2017

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2

Philipp E Scherer

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13 August 2017

Andrea R Nawrocki

1

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13 August 2017

publication date

1 September 2005

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13 August 2017

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13 August 2017

volume

10

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13 August 2017

issue

18

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13 August 2017

page(s)

1219-1230

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Atherosclerosis. the road ahead

13 August 2017

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7 January 2021

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7 January 2021

Lipid metabolic enzymes: emerging drug targets for the treatment of obesity

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7 January 2021

New insights into inhibitors of adipogenesis

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7 January 2021

Obesity and the regulation of energy balance

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7 January 2021

Gene expression in visceral and subcutaneous adipose tissues.

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7 January 2021

Life without white fat: a transgenic mouse

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7 January 2021

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

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7 January 2021

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

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7 January 2021

Acquired and inherited lipodystrophies

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7 January 2021

Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c

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7 January 2021

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

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7 January 2021

Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with2H2O

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7 January 2021

Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA.

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7 January 2021

Adipocyte differentiation and gene expression

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7 January 2021

Lipotoxic diseases of nonadipose tissues in obesity

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7 January 2021

Adipose cell apoptosis: death in the energy depot

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7 January 2021

Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation

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7 January 2021

Expression and regulation of neuronal apoptosis inhibitory protein during adipocyte differentiation

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7 January 2021

Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity.

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7 January 2021

Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy

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7 January 2021

Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit

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7 January 2021

Human adipocyte apoptosis occurs in malignancy

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7 January 2021

Adipose tissue mass can be regulated through the vasculature

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7 January 2021

Adipose tissue growth and regression are regulated by angiopoietin-1

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7 January 2021

Reversal of obesity by targeted ablation of adipose tissue

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7 January 2021

The function of leptin in nutrition, weight, and physiology

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7 January 2021

Adipose tissue as an active endocrine organ: recent advances

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7 January 2021

Minireview: The adipocyte--at the crossroads of energy homeostasis, inflammation, and atherosclerosis

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7 January 2021

The clinical uses of leptin

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7 January 2021

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

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7 January 2021

Leptin-replacement therapy for lipodystrophy.

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7 January 2021

Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal

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7 January 2021

Adiponectin: systemic contributor to insulin sensitivity

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7 January 2021

Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin

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7 January 2021

Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients

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7 January 2021

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice

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7 January 2021

Adiponectin-mediated modulation of hypertrophic signals in the heart

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7 January 2021

Adiponectin acts in the brain to decrease body weight.

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7 January 2021

Disulfide-dependent multimeric assembly of resistin family hormones

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7 January 2021

Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity

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7 January 2021

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

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7 January 2021

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

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7 January 2021

Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators

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7 January 2021

Role of resistin in diet-induced hepatic insulin resistance

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7 January 2021

The hormone resistin links obesity to diabetes

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7 January 2021

Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production

1 reference

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7 January 2021

15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma

1 reference

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7 January 2021

The mechanisms of action of PPARs

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7 January 2021

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

1 reference

7 January 2021

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity

1 reference

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7 January 2021

Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes

1 reference

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7 January 2021

A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity

1 reference

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7 January 2021

PPARgamma and atherosclerosis: effects on cell growth and movement

1 reference

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7 January 2021

Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice

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7 January 2021

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

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7 January 2021

Tumor Necrosis Factor α and Interleukin 1β Enhance the Cortisone/Cortisol Shuttle

1 reference

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7 January 2021

Tumor necrosis factor alpha and phorbol 12-myristate-13-acetate down-regulate human 11beta-hydroxysteroid dehydrogenase type 2 through p50/p50 NF-kappaB homodimers and Egr-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

A transgenic model of visceral obesity and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications

1 reference

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7 January 2021

Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Effects of low-dose prednisone on bone metabolism

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7 January 2021

Influence of glucocorticoids on human osteoclast generation and activity

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7 January 2021

Falls, fractures, and osteoporosis after stroke: time to think about protection?

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7 January 2021

Estrogen prevents bone loss through transforming growth factor beta signaling in T cells

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7 January 2021

Multilineage potential of adult human mesenchymal stem cells

1 reference

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7 January 2021

Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

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7 January 2021

Bone is a target for the antidiabetic compound rosiglitazone.

1 reference

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7 January 2021

Lovastatin inhibits adipogenic and stimulates osteogenic differentiation by suppressing PPARγ2 and increasing Cbfa1/Runx2 expression in bone marrow mesenchymal cell cultures

1 reference

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7 January 2021

Roles of peroxisome proliferator-activated receptors delta and gamma in myoblast transdifferentiation

1 reference

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7 January 2021

Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation

1 reference

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7 January 2021

Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes

1 reference

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7 January 2021

The delicate balance between fat and muscle: adipokines in metabolic disease and musculoskeletal inflammation

1 reference

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7 January 2021

Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes

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7 January 2021

Adipokines: molecular links between obesity and atheroslcerosis

1 reference

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7 January 2021

Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association

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7 January 2021

Hyperglycemia-induced production of acute phase reactants in adipose tissue

1 reference

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7 January 2021

Adipose tissue, inflammation, and cardiovascular disease

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7 January 2021

Prevention of fat-induced insulin resistance by salicylate

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7 January 2021

Inflammatory pathways and insulin action

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7 January 2021

A central role for JNK in obesity and insulin resistance

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7 January 2021

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

IKK-beta links inflammation to obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM.

1 reference

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7 January 2021

Lowered tumor necrosis factor receptors, but not increased insulin sensitivity, with infliximab

1 reference

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7 January 2021

Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab

1 reference

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7 January 2021

Developmental time and mortality of larvae of Triatoma infestans infected with Trypanosoma cruzi.

1 reference

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7 January 2021

The adipocyte as an important target cell for Trypanosoma cruzi infection

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Obesity-induced inflammatory changes in adipose tissue.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Preadipocyte conversion to macrophage. Evidence of plasticity.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity

1 reference

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7 January 2021

Cholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia

1 reference

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7 January 2021

HMG-CoA reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Role of caveolae and caveolins in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Triacylglycerol is synthesized in a specific subclass of caveolae in primary adipocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Antisense therapy for cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Selecting protein tyrosine phosphatases as drug targets

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat.

1 reference

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7 January 2021

Applying antisense technology: Affinitak and other antisense oligonucleotides in clinical development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Increased oxidative stress in obesity and its impact on metabolic syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

The mammalian unfolded protein response

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903569-5

7 January 2021

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

1 reference

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7 January 2021

Biochemistry and molecular cell biology of diabetic complications

1 reference

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7 January 2021

Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.

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7 January 2021

Magic bullets melt fat.

1 reference

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7 January 2021

10.1016/S1359-6446(05)03569-5

Identifiers

DOI

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13 August 2017

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