Opinion: What is the role of protein aggregation in neurodegeneration? (Q36259086)

13 August 2017

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title

Opinion: What is the role of protein aggregation in neurodegeneration? (English)

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13 August 2017

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Christopher A Ross

1

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13 August 2017

Michelle A Poirier

series ordinal

2

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13 August 2017

publication date

1 November 2005

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Nature Reviews Molecular Cell Biology

13 August 2017

published in

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13 August 2017

volume

6

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13 August 2017

issue

11

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13 August 2017

page(s)

891-898

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

13 August 2017

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Huntingtin aggregation and toxicity in Huntington's disease

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Protein aggregation and neurodegenerative disease

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Protein folding and misfolding

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Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

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Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

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31 March 2020

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

31 March 2020

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Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

31 March 2020

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Neurodegenerative disease: amyloid pores from pathogenic mutations

31 March 2020

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Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

31 March 2020

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

31 March 2020

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Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

31 March 2020

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Mutational analysis of the structural organization of polyglutamine aggregates

31 March 2020

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31 March 2020

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Impairment of the ubiquitin-proteasome system by protein aggregation

31 March 2020

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Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

31 March 2020

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Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

31 March 2020

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

31 March 2020

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Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

31 March 2020

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Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

31 March 2020

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Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

31 March 2020

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CREB-binding protein sequestration by expanded polyglutamine

31 March 2020

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Evidence for a recruitment and sequestration mechanism in Huntington's disease

31 March 2020

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Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

31 March 2020

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Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

31 March 2020

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Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

31 March 2020

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Amyloid ion channels: a common structural link for protein-misfolding disease

31 March 2020

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Huntington Disease and the Related Disorder, Dentatorubral-Pallidoluysian Atrophy (DRPLA)

31 March 2020

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31 March 2020

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31 March 2020

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Protein aggregation in motor neurone disorders.

31 March 2020

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31 March 2020

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Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view

31 March 2020

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Identifiers

DOI

10.1038/NRM1742

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13 August 2017

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