Hematopoietic stem cell gene therapy with drug resistance genes: an update (Q36204222)

12 August 2017

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title

Hematopoietic stem cell gene therapy with drug resistance genes: an update (English)

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12 August 2017

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Tulin Budak-Alpdogan

1

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12 August 2017

Debabrata Banerjee

series ordinal

2

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12 August 2017

Joseph R Bertino

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3

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12 August 2017

language of work or name

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1 November 2005

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12 August 2017

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12 August 2017

volume

12

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12 August 2017

issue

11

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12 August 2017

page(s)

849-863

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Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells.

12 August 2017

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Gene transfer with foamy virus vectors

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Superior transduction of mouse hematopoietic stem cells with 10A1 and VSV-G pseudotyped retrovirus vectors.

21 January 2018

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Transplantation of transduced nonhuman primate CD34+ cells using a gibbon ape leukemia virus vector: restricted expression of the gibbon ape leukemia virus receptor to a subset of CD34+ cells

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Oncoretroviral gene transfer to NOD/SCID repopulating cells using three different viral envelopes

21 January 2018

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Lentiviral vectors pseudotyped with a modified RD114 envelope glycoprotein show increased stability in sera and augmented transduction of primary lymphocytes and CD34+ cells derived from human and nonhuman primates.

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Optimized retroviral transduction protocol for human progenitor cells utilizing fibronectin fragments.

21 January 2018

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Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors

21 January 2018

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Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34+ cells

21 January 2018

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Centrifugal enhancement of retroviral mediated gene transfer

21 January 2018

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Increased gene transfer into human cord blood cells by centrifugation-enhanced transduction in fibronectin fragment-coated tubes

21 January 2018

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Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro

21 January 2018

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High-efficiency gene transfer into rhesus macaque primary T lymphocytes by combining 32 degrees C centrifugation and CH-296-coated plates: effect of gene transfer protocol on T cell homing receptor expression

21 January 2018

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

21 January 2018

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Gene therapy. As Gelsinger case ends, gene therapy suffers another blow

21 January 2018

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"Turning the tables"--making normal marrow resistant to chemotherapy.

21 January 2018

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Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase

21 January 2018

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Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.

21 January 2018

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Construction of MDR1 vectors for gene therapy

21 January 2018

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Emerging new therapies for chemotherapy-resistant cancer using adenoviral vectors

21 January 2018

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Retroviral expression of a mutant (Gly-533) human DNA topoisomerase I cDNA confers a dominant form of camptothecin resistance

21 January 2018

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Marrow protection - transduction of hematopoietic cells with drug resistance genes

21 January 2018

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Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice

21 January 2018

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Chemoprotection and selection by chemotherapy of multidrug resistance-associated protein-1 (MRP1) transduced cells.

21 January 2018

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Drug resistance gene transfer: Stem cell protection and therapeutic efficacy.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Protection and selection for gene therapy in the hematopoietic system

21 January 2018

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Hematoprotection by Transfer of Drug-Resistance Genes

21 January 2018

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Hematopoietic stem cell gene therapy: progress toward therapeutic targets

21 January 2018

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Transfer of drug resistance genes in hematopoietic progenitors for chemoprotection: is it still an option?

21 January 2018

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Clinical relevance of MGMT in the treatment of cancer

21 January 2018

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Myeloprotection with drug-resistance genes

21 January 2018

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Augmentation of methotrexate resistance with coexpression of metabolically related genes

21 January 2018

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Recent developments in gene therapy for oncology and hematology

21 January 2018

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Feasibility of multidrug resistance (MDR-1) gene transfer in patients undergoing high-dose therapy and peripheral blood stem cell transplantation for lymphoma

21 January 2018

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The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells.

21 January 2018

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Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

21 January 2018

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Retroviral-mediated transfer and expression of the multidrug resistance protein 1 gene (MRP1) protect human hematopoietic cells from antineoplastic drugs

21 January 2018

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Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia

21 January 2018

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Co-expression of the herpes simplex virus thymidine kinase gene potentiates methotrexate resistance conferred by transfer of a mutated dihydrofolate reductase gene

21 January 2018

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Generation of dual resistance to 4-hydroperoxycyclophosphamide and methotrexate by retroviral transfer of the human aldehyde dehydrogenase class 1 gene and a mutated dihydrofolate reductase gene

21 January 2018

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Efficient protection of cells from the genotoxicity of nitrosoureas by the retrovirus-mediated transfer of human O6-methylguanine-DNA methyltransferase using bicistronic vectors with human multidrug resistance gene 1.

21 January 2018

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Increased resistance to nitrogen mustards and antifolates following in vitro selection of murine fibroblasts and primary hematopoietic cells transduced with a bicistronic retroviral vector expressing the rat glutathione S-transferase A3 and a mutant

21 January 2018

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Retroviral Transduction of a Mutant Dihydrofolate Reductase-Thymidylate Synthase Fusion Gene into Murine Marrow Cells Confers Resistance to Both Methotrexate and 5-Fluorouracil

21 January 2018

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Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents

21 January 2018

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A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines

21 January 2018

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Expression of a novel double-mutant dihydrofolate reductase-cytidine deaminase fusion gene confers resistance to both methotrexate and cytosine arabinoside

21 January 2018

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Autologous hematopoietic stem cell transplantation for breast cancer in Europe: critical evaluation of data from the European Group for Blood and Marrow Transplantation (EBMT) Registry 1990-1999.

21 January 2018

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High dose chemotherapy and hematopoietic progenitor cell transplantation for breast cancer

21 January 2018

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A novel dual function retrovirus expressing multidrug resistance 1 and O6-alkylguanine-DNA-alkyltransferase for engineering resistance of haemopoietic progenitor cells to multiple chemotherapeutic agents

21 January 2018

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The Role of ABC Transporters in Clinical Practice

21 January 2018

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Multidrug resistance in oncology: diagnostic and therapeutic approaches.

21 January 2018

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Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia

21 January 2018

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Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein

21 January 2018

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Poor expression of MDR1 transgene in HeLa cells by bicistronic Moloney murine leukemia virus-based vector.

21 January 2018

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Impact of splice-site mutations of the human MDR1 cDNA on its stability and expression following retroviral gene transfer

21 January 2018

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Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells

21 January 2018

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Multidrug resistance 1 gene transfer can confer chemoprotection to human peripheral blood progenitor cells engrafted in immunodeficient mice

21 January 2018

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MDR1 gene expression in NOD/SCID repopulating cells after retroviral gene transfer under clinically relevant conditions.

21 January 2018

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Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy

21 January 2018

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Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients

21 January 2018

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Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment

21 January 2018

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In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning

21 January 2018

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DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.

21 January 2018

1 reference

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Carcinogenesis in F-344 rats induced by nitrosohydroxyalkyl-chloroethylureas

21 January 2018

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Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis

21 January 2018

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High-dose BCNU followed by autologous hematopoietic stem cell transplantation in supratentorial high-grade malignant gliomas: a retrospective analysis of 114 patients.

21 January 2018

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High dose BCNU chemotherapy with autologous bone marrow transplantation and full dose radiotherapy for grade IV astrocytoma.

21 January 2018

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Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow

21 January 2018

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Methotrexate resistance conferred by transplantation of drug-resistant transgenic marrow cells fractionated bycounterflow elutriation

21 January 2018

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Systemic resistance to methotrexate in transgenic mice carrying a mutant dihydrofolate reductase gene

21 January 2018

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Mechanism of synergistic cell killing when methotrexate precedes cytosine arabinoside: study of L1210 and human leukemic cells

21 January 2018

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Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene

21 January 2018

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Ifosfamide, carboplatin, and etoposide: a highly effective cytoreduction and peripheral-blood progenitor-cell mobilization regimen for transplant-eligible patients with non-Hodgkin's lymphoma

21 January 2018

1 reference

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Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma

21 January 2018

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Age-adjusted International Prognostic Index predicts autologous stem cell transplantation outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma

21 January 2018

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Autologous marrow transplantation for malignant lymphoma: a report of 101 cases from Seattle

21 January 2018

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Outcome of relapsed non-Hodgkin's lymphoma patients after allogeneic and autologous transplantation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Outcome and toxicity of salvage treatment on patients relapsing after autologous hematopoietic stem cell transplantation--experience from a single center.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

In vivo selection of retrovirally transduced hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Gene therapy for adenosine deaminase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Adenosine deaminase gene therapy protocol revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Prolonged production of NADPH oxidase-corrected granulocytes after gene therapy of chronic granulomatous disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Progress in gene therapy for chronic granulomatous disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Gene therapy for genetic haematological disorders and immunodeficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Engraftment of hematopoietic progenitor cells transduced with the Fanconi anemia group C gene (FANCC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Gene therapy of X-linked severe combined immunodeficiency

21 January 2018

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Advances in lentiviral vector design for gene-modification of hematopoietic stem cells.

21 January 2018

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Gene therapy of Fanconi anemia: preclinical efficacy using lentiviral vectors.

21 January 2018

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Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Gene therapy with viral vectors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Effects of transplantation on the primitive immunohematopoietic stem cell

21 January 2018

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Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91.

21 January 2018

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Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector

21 January 2018

1 reference

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Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma -chain and multidrug resistance (MDR1) transgenes in canine bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Restoration of transgene expression in hematopoietic cells with drug-selectable marker genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

In vivo selection of hematopoietic stem cells transduced with DHFR-expressing retroviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Methotrexate selectable retroviral vectors for Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

In vivo methotrexate selection of murine hemopoietic cells transduced with a retroviral vector for Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Transcription start regions in the human genome are favored targets for MLV integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

The future for gene therapy--a reevaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Gene therapy insertional mutagenesis insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

Gene therapy for adenosine deaminase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Transduction of multiple cell types using improved conditions for gene delivery and expression of SV40 pseudovirions packaged in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

1 reference

7 January 2021

Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Optimization of retroviral gene transduction of mobilized primitive hematopoietic progenitors by using thrombopoietin, Flt3, and Kit ligands and RetroNectin culture

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Evaluation of a Cytokine Combination Including Thrombopoietin for Improved Transduction of a Retroviral Gene into G‐CSF‐Mobilized CD34 + Human Blood Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Optimization of gene transfer into primitive human hematopoietic cells of granulocyte-colony stimulating factor-mobilized peripheral blood using low-dose cytokines and comparison of a gibbon ape leukemia virus versus an RD114-pseudotyped retroviral

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Prolonged high-level detection of retrovirally marked hematopoietic cells in nonhuman primates after transduction of CD34+ progenitors using clinically feasible methods

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Workshop on long-term follow-up of participants in human gene transfer research

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Use of variants of dihydrofolate reductase in gene transfer to produce resistance to methotrexate and trimetrexate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Genetic modification of haematopoietic cells for combined resistance to podophyllotoxins, other agents covered by MDR1-mediated efflux activity and nitrosoureas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Post-transplant methotrexate administration leads to improved curability of mice bearing a mammary tumor transplanted with marrow transduced with a mutant human dihydrofolate reductase cDNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

The correlation of maximal drug dose, tumor recruitment, and sequence timing with therapeutic advantage: schedule-dependent toxicity of cytosine arabinoside

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Progressive disease following autologous transplantation in patients with chemosensitive relapsed or primary refractory Hodgkin's disease or aggressive non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Differential transduction efficiency of SCID-repopulating cells derived from umbilical cord blood and granulocyte colony-stimulating factor-mobilized peripheral blood

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Ifosfamide, etoposide, cytarabine, and methotrexate as salvage chemotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

The VIM3-AraC regimen followed by autologous stem cell transplantation in refractory or relapsing aggressive non-Hodgkin's lymphoma. A prospective study of 71 consecutive cases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Retroviral mediated transfer of the cDNA for human glucocerebrosidase into hematopoietic stem cells of patients with Gaucher disease. A phase I study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

New genes involved in cancer identified by retroviral tagging

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Gene therapy of severe combined immunodeficiencies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700866

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700866

1 reference

12 August 2017

1 reference