Use of yeast as a model system to investigate protein conformational diseases (Q36141393)

12 August 2017

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title

Use of yeast as a model system to investigate protein conformational diseases (English)

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12 August 2017

Christina M Coughlan

1

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12 August 2017

Jeffrey L Brodsky

series ordinal

2

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12 August 2017

publication date

1 June 2005

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12 August 2017

published in

Molecular Biotechnology

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12 August 2017

volume

30

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12 August 2017

issue

2

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12 August 2017

page(s)

171-180

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Association between calnexin and a secretion-incompetent variant of human alpha 1-antitrypsin.

12 August 2017

cites work

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12 December 2020

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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12 December 2020

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

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12 December 2020

The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome

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12 December 2020

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR

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12 December 2020

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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12 December 2020

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

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12 December 2020

Evidence for a protein mutator in yeast: role of the Hsp70-related chaperone ssb in formation, stability, and toxicity of the [PSI] prion

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12 December 2020

Chaperones that cure yeast artificial [PSI+] and their prion-specific effects

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12 December 2020

Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

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12 December 2020

Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein

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12 December 2020

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

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12 December 2020

Reconstitution of gamma-secretase activity

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12 December 2020

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+]

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12 December 2020

Conformational variations in an infectious protein determine prion strain differences

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12 December 2020

APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity

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12 December 2020

A yeast genetic assay for caspase cleavage of the amyloid-beta precursor protein.

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12 December 2020

Characterization of β-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases

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12 December 2020

Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency

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12 December 2020

The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment

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12 December 2020

Protein disaggregation mediated by heat-shock protein Hsp104.

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12 December 2020

ER quality control: towards an understanding at the molecular level

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12 December 2020

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells

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12 December 2020

Organizational diversity among distinct glycoprotein endoplasmic reticulum-associated degradation programs

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12 December 2020

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

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12 December 2020

Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate binding

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12 December 2020

Chaperoning the maturation of the cystic fibrosis transmembrane conductance regulator

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12 December 2020

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

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12 December 2020

Non-Mendelian Mutation Allowing Ureidosuccinic Acid Uptake in Yeast

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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12 December 2020

Selective protein degradation in the yeast exocytic pathway

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12 December 2020

Inherited amyloidosis

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12 December 2020

Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast.

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12 December 2020

Prions affect the appearance of other prions: the story of [PIN(+)].

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12 December 2020

Antagonistic interactions between yeast [PSI(+)] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p

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12 December 2020

Role of CFTR in airway disease

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12 December 2020

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12 December 2020

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

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12 December 2020

Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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12 December 2020

Identification of an inhibitor of hsc70-mediated protein translocation and ATP hydrolysis

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12 December 2020

When more is less: pathogenesis of glutamine repeat neurodegenerative diseases

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12 December 2020

Dissecting glycoprotein quality control in the secretory pathway

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12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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12 December 2020

Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity

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12 December 2020

Emerging principles of conformation-based prion inheritance

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12 December 2020

Alzheimer's disease: a central role for amyloid

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12 December 2020

The role of Sis1 in the maintenance of the [RNQ+] prion

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12 December 2020

Prions in Saccharomyces and Podospora spp.: protein-based inheritance.

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12 December 2020

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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12 December 2020

Differential requirements of novel A1PiZ degradation deficient (ADD)genes in ER-associated protein degradation

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12 December 2020

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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12 December 2020

Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function

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12 December 2020

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

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12 December 2020

Biosynthesis and degradation of CFTR.

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12 December 2020

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

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12 December 2020

Investigating protein conformation-based inheritance and disease in yeast

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12 December 2020

The molecular chaperone calnexin binds Glc1Man9GlcNAc2 oligosaccharide as an initial step in recognizing unfolded glycoproteins

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12 December 2020

Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins

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12 December 2020

Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

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12 December 2020

Recent advances in understanding the pathogenesis of Huntington's disease

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12 December 2020

Processing of the Alzheimer's disease amyloid precursor protein in Pichia pastoris: immunodetection of alpha-, beta-, and gamma-secretase products.

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12 December 2020

A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP

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12 December 2020

23 genes, 23 years later

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12 December 2020

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

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12 December 2020

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

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12 December 2020

Neuroscience. New leads on the 'how' of Alzheimer's

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12 December 2020

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

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12 December 2020

Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting

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12 December 2020

Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

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12 December 2020

Degradation of CFTR by the ubiquitin-proteasome pathway

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12 December 2020

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

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12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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12 December 2020

The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis

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12 December 2020

Genetic control of the cell division cycle in yeast

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12 December 2020

[URE3] prion propagation in Saccharomyces cerevisiae: requirement for chaperone Hsp104 and curing by overexpressed chaperone Ydj1p

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12 December 2020

Generation of the amyloid-beta peptide N terminus in Saccharomyces cerevisiae expressing human Alzheimer's amyloid-beta precursor protein.

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12 December 2020

Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

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12 December 2020

Genetic and molecular advances in Alzheimer's disease

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12 December 2020

Molecular pathogenesis of liver disease in alpha1-antitrypsin deficiency

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12 December 2020

The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Conformational disease

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12 December 2020

Antagonistic interactions between yeast chaperones Hsp104 and Hsp70 in prion curing

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12 December 2020

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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12 December 2020

Chemical chaperones correct the mutant phenotype of the ΔF508 cystic fibrosis transmembrane conductance regulator protein

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12 December 2020

Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast

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12 December 2020

Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

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12 December 2020

Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator

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12 December 2020

Identifiers

DOI

10.1385/MB:30:2:171

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Dimensions Publication ID

12 August 2017

1020952831

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