Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds (Q36059350)

11 August 2017

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds (English)

1 reference

11 August 2017

1

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1 June 2020

Sabine Gerbal-Chaloin

6

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1 June 2020

Vincent Cavailles

11

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1 June 2020

Martine Daujat-Chavanieu

12

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1 June 2020

Jean Marc Pascussi

14

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1 June 2020

William Bourguet

16

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1 June 2020

4

Marina Grimaldi

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1 June 2020

5

Abdelhay Boulahtouf

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1 June 2020

15

Patrick Balaguer

1 reference

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1 June 2020

13

Valérie Vivat

1 reference

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1 June 2020

author name string

Béatrice Dendele

2

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1 June 2020

Tiphaine Huet

3

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1 June 2020

Bertrand Beucher

7

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1 June 2020

Dominique Roecklin

8

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1 June 2020

Christina Muller

9

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1 June 2020

Roger Rahmani

10

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1 June 2020

language of work or name

English

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publication date

3 September 2015

1 reference

11 August 2017

Nature Communications

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26333997%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

6

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1 June 2020

page(s)

8089

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Creative Commons Attribution 4.0 International

1 June 2020

copyright license

start time

3 September 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice

2 October 2017

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2 October 2017

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Endocrine disrupting chemicals and disease susceptibility

2 October 2017

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Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.

2 October 2017

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MolProbity: all-atom structure validation for macromolecular crystallography

2 October 2017

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Prenatal exposure to bisphenol a at environmentally relevant doses adversely affects the murine female reproductive tract later in life

2 October 2017

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2 October 2017

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Bisphenol A: Perinatal exposure and body weight

2 October 2017

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Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders.

2 October 2017

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Structural basis for the activation of PPARgamma by oxidized fatty acids

2 October 2017

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Evolution of pharmacologic specificity in the pregnane X receptor

2 October 2017

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Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

2 October 2017

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Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

2 October 2017

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Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis

2 October 2017

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Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

2 October 2017

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Structural plasticity in the oestrogen receptor ligand-binding domain

2 October 2017

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Estrogens and antiestrogens activate hPXR.

2 October 2017

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Overview of nomenclature of nuclear receptors

2 October 2017

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

2 October 2017

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Functional evolution of the pregnane X receptor

2 October 2017

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A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta

2 October 2017

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Identification of new human pregnane X receptor ligands among pesticides using a stable reporter cell system.

2 October 2017

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Environmental xenobiotics and nuclear receptors--interactions, effects and in vitro assessment.

2 October 2017

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2 October 2017

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2 October 2017

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A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides

2 October 2017

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Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein

2 October 2017

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Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity

2 October 2017

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Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor

2 October 2017

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Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

2 October 2017

1 reference

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Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

2 October 2017

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A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity

2 October 2017

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

2 October 2017

1 reference

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569708

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569708

Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders

2 October 2017

1 reference

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Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569708

23 September 2018

Human hepatocyte culture

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26333997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Long-term primary cultures of adult human hepatocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26333997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26333997

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS9089

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26333997%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

ADS bibcode

2015NatCo...6.8089D

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26333997%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

26333997

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26333997%20AND%20SRC:MED&resulttype=core&format=json