Aurora-kinase inhibitors as anticancer agents (Q35968406)

11 August 2017

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title

Aurora-kinase inhibitors as anticancer agents (English)

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11 August 2017

Nicholas Keen

1

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11 August 2017

Stephen Taylor

series ordinal

2

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11 August 2017

language of work or name

English

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publication date

1 December 2004

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11 August 2017

published in

Nature Reviews Cancer

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11 August 2017

volume

4

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11 August 2017

issue

12

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11 August 2017

page(s)

927-936

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Genetic instabilities in human cancers

11 August 2017

cites work

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Chromosomal passengers and the (aurora) ABCs of mitosis

21 January 2018

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The cellular geography of aurora kinases

21 January 2018

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Mitotic kinases as regulators of cell division and its checkpoints

21 January 2018

1 reference

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

21 January 2018

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A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

21 January 2018

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Surgeons as an Integral Part of the Cancer Research Team

21 January 2018

1 reference

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

21 January 2018

1 reference

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

21 January 2018

1 reference

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

21 January 2018

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

21 January 2018

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AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

21 January 2018

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

21 January 2018

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Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3

21 January 2018

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Aurora kinases link chromosome segregation and cell division to cancer susceptibility

21 January 2018

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Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle

21 January 2018

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Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

21 January 2018

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Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

21 January 2018

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G1 tetraploidy checkpoint and the suppression of tumorigenesis

21 January 2018

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Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

21 January 2018

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How cells get the right chromosomes

21 January 2018

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The spindle checkpoint: structural insights into dynamic signalling

21 January 2018

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The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation

21 January 2018

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The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

21 January 2018

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Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

21 January 2018

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Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

21 January 2018

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The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis

21 January 2018

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Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis

21 January 2018

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Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

21 January 2018

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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

21 January 2018

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Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint

21 January 2018

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Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation

21 January 2018

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Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis

21 January 2018

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AIM-1: a mammalian midbody-associated protein required for cytokinesis

21 January 2018

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

21 January 2018

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Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

21 January 2018

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 January 2018

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The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

21 January 2018

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Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool

21 January 2018

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Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

21 January 2018

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Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.

21 January 2018

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TACC1-chTOG-Aurora A protein complex in breast cancer

21 January 2018

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Aurora B -TACC1 protein complex in cytokinesis

21 January 2018

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Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C

21 January 2018

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Mitotic kinase expression and colorectal cancer progression

31 March 2020

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Amplification/overexpression of a mitotic kinase gene in human bladder cancer

31 March 2020

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Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non‐Hodgkin's lymphoma

31 March 2020

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Antitumor activity of a kinesin inhibitor

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1502

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Dimensions Publication ID

11 August 2017

1007682820

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Fatcat ID

release_q7qqrfd2bbb6zcaqdsrhvbapyi

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Fatcat

https://api.fatcat.wiki/v0/release/q7qqrfd2bbb6zcaqdsrhvbapyi

mapped directly with Wikidata item

24 November 2022

based on heuristic

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